Lin Xu, Joshua L Pierce, Angelica Sanchez, Kenneth S Chen, Abhay A Shukla, Nicholas J Fustino, Sarai H Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D Krailo, Furqan Shaikh, Deborah F Billmire, Farzana Pashankar, Jessica Bestrashniy, J Wolter Oosterhuis, Ad J M Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N Poynter, Dinesh Rakheja, Leendert H J Looijenga, Bruce W Draper, A Lindsay Frazier, James F Amatruda
Germ cell tumors (GCTs) are neoplasms of the testis, ovary and extragonadal sites that occur in infants, children, adolescents and adults. Post-pubertal (type II) malignant GCTs may present as seminoma, non-seminoma or mixed histologies. In contrast, pre-pubertal (type I) GCTs are limited to (benign) teratoma and (malignant) yolk sac tumor (YST). Epidemiologic and molecular data have shown that pre- and post-pubertal GCTs arise by distinct mechanisms. Dedicated studies of the genomic landscape of type I and II GCT in children and adolescents are lacking...
May 6, 2023: Nature Communications