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https://read.qxmd.com/read/38525405/ovarian-yolk-sac-tumors-is-fertility-preservation-possible
#1
Fariba Behnamfar, Maryam Nazemi, Behnoosh Mohamadi
Yolk sac tumors make up 14% to 20% of all malignant ovarian germ cell tumors. Serum alpha-fetoprotein (AFP) levels are elevated in a significant number of patients and are useful for monitoring the response to treatment and for post-treatment surveillance. Surgery is required for diagnosis, staging, and treatment. The first case is a 12-year-old girl presented with abdominal pain. The ultrasonography (US) showed a huge pelvic tumor. AFP level was high (1000 mg/ml). Right salpingo-oophorectomy and pelvic lymphadenectomy were done...
2024: Advanced Biomedical Research
https://read.qxmd.com/read/38511034/germ-cell-tumor-presenting-as-a-mesenteric-cyst-a-case-report-and-literature-review
#2
Sana Ahuja, Saba Naaz, Adil Aziz Khan, Sufian Zaheer
Mesenteric cysts, typically benign and asymptomatic, are incidental findings during abdominal investigations for nonspecific symptoms. Their origin is commonly in the mesentery of the small bowel, mesocolon, or retroperitoneum. This paper reports a rare case of a 22-year-old male with a mesenteric cyst presenting as a right lower abdominal mass. Ultrasonography revealed a heterogenous collection, leading to surgical excision. Histopathology unexpectedly revealed an extragonadal yolk sac tumor (YST) originating in the mesentery, a rarity often misdiagnosed as a cyst...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38499669/p53-overexpression-may-represent-an-early-marker-of-clinicopathologic-progression-in-vasculogenic-mesenchymal-lesions-of-germ-cell-tumor-origin
#3
JOURNAL ARTICLE
Reem Youssef, Thomas M Ulbright, Andres M Acosta
Vasculogenic mesenchymal lesions (VMLs) of germ cell tumor origin are thought to originate in postpubertal-type yolk sac tumor components and include a spectrum of lesions from teratoma with vasculogenic stroma (TVS), to low and high-grade vasculogenic mesenchymal tumors (VMTs). VMLs exhibit rudimentary to well-developed neoplastic vessels within primitive mesenchyme, being considered a neoplastic reiteration of embryonic vasculogenesis in the splanchnic mesoderm of the yolk sac. They occur in patients with primary mediastinal germ cell tumors after chemotherapy, and a subset progresses to "somatic-type" sarcomas [including angiosarcoma (AS)], with high-grade VMTs likely portending a higher risk...
March 19, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38476210/spontaneous-rupture%C3%A2-induced-life%C3%A2-threatening-mediastinal-mixed-germ-cell-tumor-a-case-report-and-therapeutic-considerations
#4
Xiaosong Li, Shenghan Xu, Yunbin Li, Yanping Tang, Kaiying Wang, Yumeng Lei, Jian Ma, Jian Li
Spontaneous rupture and hemorrhage of mediastinal germ cell tumors is a rare occurrence. In the current report, the case of a 20-year-old male patient who was admitted with chest tightness and dyspnea is presented. An urgent chest CT scan revealed a large tumor in the right anterior mediastinum, measuring ~12 cm in diameter, with associated intratumoral hemorrhage. An emergency thoracotomy was performed to excise the lesion, which revealed that the bleeding was caused by a ruptured tumor. Postoperative pathological findings revealed a mediastinal mixed germ cell tumor consisting of four pathological types: Embryonal carcinoma, seminoma, yolk sac tumor and immature teratoma...
April 2024: Oncology Letters
https://read.qxmd.com/read/38466424/alpha-fetoprotein-producing-endometrioid-carcinoma-arising-in-an-adenomyoma-of-the-uterus
#5
JOURNAL ARTICLE
Yuzo Oyama, Takahiro Kusaba, Kasumi Takao, Eri Obata, Mitsutake Yano, Kazuhiro Kawamura, Haruto Nishida, Tsutomu Daa
We report a case of alpha-fetoprotein-producing endometrioid carcinoma (AFP-EC) that originated within an adenomyoma of the uterine corpus. A 76-year-old Japanese woman was incidentally discovered to have a uterine tumor along with multiple lung nodules. Upon surgical removal of the uterus, it was revealed that the tumor was situated within the adenomyoma. The tumor exhibited microfollicular structures and solid growth patterns, with hyaline globules, clear cell glands, and primitive tumor cells. Immunohistochemical analysis indicated the presence of germ cell markers, including AFP, SALL4, and glypican3, leading to final diagnosis of AFP-EC...
March 11, 2024: Medical Molecular Morphology
https://read.qxmd.com/read/38449931/a-case-report-on-alpha-fetoprotein-positive-colorectal-cancer
#6
Wendy Hui Li Yap, Hajah Maisarah Haji Awang Sharif, Amy Thien
Alpha-fetoprotein (AFP) is commonly produced by hepatocellular carcinoma and yolk sac tumors, while AFP in colorectal cancer (CRC) is a rare association. We report a case of a patient with primary AFP-producing CRC, which was successfully treated with surgery and adjuvant chemotherapy. This case highlighted the importance of recognizing a case of AFP-producing CRC.  This case report discussed a 59-year-old male who had a history of hepatitis B infection, with two months of intermittent fresh per rectal bleeding...
February 2024: Curēus
https://read.qxmd.com/read/38447883/epac-inhibitor-suppresses-angiogenesis-and-tumor-growth-of-triple-negative-breast-cancer
#7
JOURNAL ARTICLE
Zishuo Li, Qiao Liu, Yuhao Cai, Na Ye, Zinan He, Yuying Yao, Yi Ding, Pingyuan Wang, Cuiling Qi, Lingyun Zheng, Lijing Wang, Jia Zhou, Qian-Qian Zhang
AIMS: Exchange protein directly activated by cAMP 1 (EPAC1), a major isoform of guanine nucleotide exchange factors, is highly expressed in vascular endothelia cells and regulates angiogenesis in the retina. High intratumor microvascular densities (MVD) resulting from angiogenesis is responsible for breast cancer development. Downregulation of EPAC1 in tumor cell reduces triple-negative breast cancer (TNBC)-induced angiogenesis. However, whether Epac1 expressed in vascular endothelial cells contributes to angiogenesis and tumor development of TNBC remains elusive...
March 4, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38444815/primary-yolk-sac-tumor-of-the-liver-a-rare-cause-of-bile-duct-obstruction
#8
Sahil M Patel, Kenneth M Sigman, Mohannad F Dugum
Primary yolk sac tumor (YST) of the liver is an extremely rare extragonadal germ cell tumor. Here, we present a case of a young man who developed primary YST of the liver which metastasized to periductal lymph nodes causing bile duct obstruction. A 32-year-old male was referred from an outside hospital for evaluation of painless jaundice. Initial investigation showed common bile duct compression from periductal lymph nodes. Inital biopsy results were concerning for adenocarcinoma. The patient was ultimately diganosed with primary YST of the liver...
2024: Case Reports in Gastrointestinal Medicine
https://read.qxmd.com/read/38438174/uterine-transposition-for-fertility-preservation-in-pelvic-cancers
#9
REVIEW
Reitan Ribeiro, Glauco Baiocchi, Andreas Obermair, Caroline Nadai Costa, Mario Leitao
OBJECTIVE: To review rates of uterine preservation and gonadal function, surgical outcomes, and pregnancy outcomes in patients undergoing surgical uterine transposition. METHODS: A structured search and analysis of the published literature on uterine transposition was conducted. Information on study type, sample size, patient characteristics, clinical indications, details of the surgical technique, trans-operative and post-operative results, success rates in preserving reproductive organ function and fertility were extracted...
March 4, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38420071/rare-presentation-and-diagnostic-challenge-of-a-germ-cell-tumor-of-the-yolk-sac-type
#10
Inês Gomes, Emanuel Jesus, Gabriela M Sousa
Opsoclonus-ataxia paraneoplastic syndrome (OAPS) is a rare neurological disorder often associated with malignancies. This case report highlights an unusual instance of OAPS linked to a yolk sac (germ cell) tumor, a correlation underrepresented in the medical literature. The patient presented with distinct neurological symptoms alongside mediastinal lymphadenopathies. The subsequent diagnostic journey revealed a yolk sac germ cell tumor. Following incisional biopsies and treatment, the patient experienced fluctuations in mental status, leading to challenges in initiating chemotherapy...
January 2024: Curēus
https://read.qxmd.com/read/38380211/a-comprehensive-review-of-current-trends-in-the-diagnosis-and-treatment-of-ovarian-germ-cell-tumors
#11
REVIEW
Ketki S Dantkale, Manjusha Agrawal
Ovarian germ cell tumors constitute a rare and intricate spectrum of neoplasms characterized by diverse histological subtypes. This comprehensive review elucidates the classification, diagnosis, treatment, prognosis, and unique challenges associated with these tumors. The classification is rooted in histological attributes, with principal subtypes encompassing dysgerminoma, immature teratoma, yolk sac tumor (endodermal sinus tumor), choriocarcinoma, and mixed germ cell tumors. Each subtype bears distinct characteristics and clinical implications, necessitating precise diagnosis and tailored therapeutic strategies...
January 2024: Curēus
https://read.qxmd.com/read/38377960/retroperitoneal-sarcomatoid-yolk-sac-tumor-in-a-chemotherapy-naive-patient-with-testicular-postpubertal-type-teratoma-a-rare-case-report-with-emphasis-on-molecular-features
#12
JOURNAL ARTICLE
Bo Zhang, Payal Kapur, Prasad R Koduru, Liwei Jia
Sarcomatoid yolk sac tumor is a very rare histologic type of testicular germ cell tumor and is mainly reported in testicular germ cell tumor patients who receive chemotherapy. Herein, we report an extremely rare concurrent retroperitoneal sarcomatoid yolk sac tumor in a man with a testicular postpuberal teratoma before he received chemotherapy. A 37-year-old man initially presented with a persistent abdominal pain. Subsequent imaging studies revealed a 9.6-cm retroperitoneal mass, and 2 testicular masses (3...
February 20, 2024: International Journal of Surgical Pathology
https://read.qxmd.com/read/38359725/survival-difference-among-adult-and-pediatric-mediastinal-yolk-sac-tumors-cases-a-meta-analysis-of-case-reports
#13
REVIEW
Anas Dabsha, Ismail A M H Elkharbotly, Mohammad Yaghmour, Amr Badr, Fady Badie, Sherif Khairallah, Yomna M Esmail, Mohamed Hossny, Amr Rizk, Amr El-Demiry, Galal Ghaly, Shaikha Al-Thani, Michelle Demetres, Abdelrahman Mohamed, Jonathan Villena-Vargas, Mona Kamal, Mohamed Rahouma
BACKGROUND: Mediastinal Yolk sac tumors (YST) are rare and highly malignant extragonadal germ cell tumors with rapid growth and early metastases. We sought to conduct a meta-analysis of published case reports/case series to compare differences in survival, demographics, and treatment modalities between adult and pediatric patients with YST. METHODS: Ovid Embase, Cochrane, and Ovid Medline databases were searched for primary mediastinal pure YST cases. The primary outcome was overall survival (OS)...
February 11, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38347538/46-xx-disorder-of-sexual-development-associated-with-mixed-germ-cell-tumor-of-the-prostate-a-rare-case-report
#14
JOURNAL ARTICLE
Changrong Wang, Jiangli Du, Xueping Xiang, Yuyong Wang, Jingjing Xiang, Qiaoping Xu
BACKGROUND: Extragonadal germ cell tumors originating from the prostate are exceptionally rare. To the best of our knowledge, there have been no reported cases of mixed germ cell tumors in individuals with 46 XX disorder of sex development. In this study, we conducted a comprehensive analysis using whole genome sequencing to investigate the clinicopathological and molecular genetic characteristics of a submitted case, with the objective of elucidating its underlying pathogenesis. CASE PRESENTATION: A 40-year-old male patient was diagnosed with a combination of 46, XX disorder of sex development and a primary prostate mixed germ cell tumor with yolk sac tumor and teratoma components...
February 12, 2024: BMC Urology
https://read.qxmd.com/read/38304749/rare-pediatric-synchronous-bilateral-testicular-germ-cell-tumors-of-different-pathological-types-a-case-report
#15
Yikun Feng, Yu Qu, Rongde Wu, Wei Liu, Guoqiang Du
The occurrence of synchronous bilateral testicular germ cell tumors (BTGCTs) of different pathologic histologic types in pediatric patients is rare. We reported a case of a left testicular yolk sac tumor (YST) combined with a right testicular mature teratoma. Left orchiectomy and right testis-sparing surgery were performed. Retroperitoneal recurrence was noted 6 months after surgery. The patient underwent reoperation for the resection of a retroperitoneal mass, which was pathologically diagnosed as a recurrent YST...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38296184/assessing-the-risk-to-develop-a-growing-teratoma-syndrome-based-on-molecular-and-epigenetic-subtyping-as-well-as-novel-secreted-biomarkers
#16
JOURNAL ARTICLE
Pailin Pongratanakul, Felix Bremmer, Stella Pauls, Gereon Poschmann, Catena Kresbach, Fatma Parmaksiz, Margaretha A Skowron, Janina Fuß, Alexa Stephan, Pia Paffenholz, Kai Stühler, Ulrich Schüller, Philipp Ströbel, Axel Heidenreich, Yue Che, Peter Albers, Daniel Nettersheim
In germ cell tumors (GCT), a growing teratoma during chemotherapy with decreasing tumor markers was defined as 'growing teratoma syndrome' (GTS) by Logothetis et al. in 1982. So far, its pathogenesis and specific treatment options remain elusive. We aimed at updating the GTS definition based on molecular and epigenetic features as well as identifying circulating biomarkers. We selected 50 GTS patients for clinical characterization and subsequently 12 samples were molecularly analyzed. We further included 7 longitudinal samples of 2 GTS patients...
January 29, 2024: Cancer Letters
https://read.qxmd.com/read/38281794/-mesonephric-like-adenocarcinoma-of-uterus-with-yolk-sac-tumor-report-of-a-case
#17
JOURNAL ARTICLE
T Yu, H X Wang, X R Zhou, X Tao, W Yuan
No abstract text is available yet for this article.
February 8, 2024: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://read.qxmd.com/read/38234964/germ-cell-tumor-of-the-yolk-sac-in-the-uterine-corpus-case-report-of-a-14-month-old-female-infant
#18
Amaranto Suárez, Javier Brito Moreno, Maria Camila Suaza Vallejo, Juan Pablo Luengas, Carlos Blanco
Malignant germ cell tumors (MGCTs) localized in the uterus are rare in prepubertal girls. They typically occur in postmenopausal women and are characterized by the presence of a pelvic mass and transvaginal bleeding. In this case, the authors describe the clinical features, radiologic findings, histopathologic description, and treatment received by an infant with a primary yolk sac tumor of the uterine wall. Currently, treatment for uterine GCTs is based on guidelines for GCTs. Surgery and bleomycin, etoposide, cisplatin (pBEP) chemotherapy are effective for uterine yolk sac tumors...
December 2023: Curēus
https://read.qxmd.com/read/38228517/-swyer-syndrome-with-gonadal-non-dysgerminoma-malignant-germ-cell-tumors-a-report-of-15-cases-in-a-national-medical-center
#19
JOURNAL ARTICLE
H Liang, S J Li, J X Yang, M Wu, D Y Cao, J H Wang, T Wang, X Y Zhang
Objective: To evaluate the incidence, treatment, and survival outcomes of Swyer syndrome with gonadal non-dysgerminoma malignant germ cell tumor (MGCT-NDG). Methods: A retrospective study was performed on Swyer syndrome patients with MGCT-NDG between January 2011 and December 2022 in Peking Union Medical College Hospital to investigate their characteristics and outcomes. Results: A total of 15 patients (4.9%, 15/307) with Swyer syndrome were identified in 307 MGCT-NDG patients. The average age at diagnosis of MGCT-NDG and Swyer syndrome were (16...
January 25, 2024: Zhonghua Fu Chan Ke za Zhi
https://read.qxmd.com/read/38218563/comparison-of-cardiotoxicity-induced-by-alectinib-apatinib-lenvatinib-and-anlotinib-in-zebrafish-embryos
#20
JOURNAL ARTICLE
Jieping Liu, Wanbo Li, Sujie Sun, Ling Huang, Mengqi Wan, Xue Li, Li Zhang, Dou Yang, Fasheng Liu, Xinjun Liao, Huiqiang Lu, Juhua Xiao, Shouhua Zhang, Zigang Cao
Four tyrosine kinase inhibitors, alectinib, apatinib, lenvatinib and anlotinib, have been shown to be effective in the treatment of clinical tumors, but their cardiac risks have also raised concerns. In this study, zebrafish embryos at 6 h post fertilization (hpf) were exposed to the four drugs at concentrations of 0.05-0.2 mg/L until 72 hpf, and then the development of these embryos was quantified, including heart rate, body length, yolk sac area, pericardial area, distance between venous sinus and balloon arteriosus (SV-BA), separation of cardiac myocytes and endocardium, gene expression, vascular development and oxidative stress...
January 11, 2024: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
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