James R McIntosh, Evan F Joiner, Jacob L Goldberg, Phoebe Greenwald, Alexandra C Dionne, Lynda M Murray, Earl Thuet, Oleg Modik, Evgeny Shelkov, Joseph M Lombardi, Zeeshan M Sardar, Ronald A Lehman, Andrew K Chan, K Daniel Riew, Noam Y Harel, Michael S Virk, Christopher Mandigo, Jason B Carmel
Volitional movement requires descending input from the motor cortex and sensory feedback through the spinal cord. We previously developed a paired brain and spinal electrical stimulation approach in rats that relies on convergence of the descending motor and spinal sensory stimuli in the cervical cord. This approach strengthened sensorimotor circuits and improved volitional movement through associative plasticity. In humans, it is not known whether posterior epidural spinal cord stimulation targeted at the sensorimotor interface or anterior epidural spinal cord stimulation targeted within the motor system is effective at facilitating brain evoked responses...
May 17, 2024: Journal of Physiology