Amyna Ismail Rehmani, Alesia Au, Carmel Montgomery, Elizabeth Papathanassoglou
BACKGROUND: Ventilator-associated pneumonia (VAP) is a significant concern in low-middle-income countries (LMICs), where the burden of hospital-acquired infections is high, and resources are low. Evidence-based guidelines exist for preventing VAP; however, these guidelines may not be adequately utilized in intensive care units of LMICs. AIM: This scoping review examined the literature regarding the use of nursing care bundles for VAP prevention in LMICs, to understand the knowledge, practice and compliance of nurses to these guidelines, as well as the barriers preventing the implementation of these guidelines...
April 13, 2024: Nursing in Critical Care
Daniela M Cioboata, Aniko M Manea, Oana C Costescu, Florina M Doandes, Timea E Brandibur, Nicoleta Lungu, Mihai Dinu, Florina Stoica, Radu E Iacob, Marioara Boia
BACKGROUND Retinopathy of prematurity (ROP), originally described as retrolental fibroplasia, represents an abnormal growth of blood vessels in the premature retina that can occur in response to oxygen therapy. The association between ROP and invasive mechanical ventilation has been widely studied in the literature; however, the relationships between different types of ventilation and ROP have not been as well documented. This study aimed to compare the association of ROP incidence with mechanical ventilation (MV), nasal continuous positive airway pressure (nCPAP), and high-flow nasal cannula (HFNC) therapies in 130 pre-term infants with gestational ages <32 weeks...
April 13, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Meghan S Vermillion, Nathan Saari, Mathieu Bray, Andrew M Nelson, Robert L Bullard, Karin Rudolph, Andrew P Gigliotti, Jeffrey Brendler, Jacob Jantzi, Philip J Kuehl, Jacob D McDonald, Mark E Burgert, Waylon Weber, Scott Sucoloski, David J Behm
As a regulator of alveolo-capillary barrier integrity, Transient Receptor Potential Vanilloid 4 (TRPV4) antagonism represents a promising strategy for reducing pulmonary edema secondary to chemical inhalation. In an experimental model of acute lung injury induced by exposure of anesthetized swine to chlorine gas by mechanical ventilation, the dose-dependent effects of TRPV4 inhibitor GSK2798745 were evaluated. Pulmonary function and oxygenation were measured hourly; airway responsiveness, wet-to-dry lung weight ratios, airway inflammation, and histopathology were assessed 24 h post-exposure...
April 2, 2024: International Journal of Molecular Sciences
Dewi Santosaningsih, Yuanita Mulyastuti, Soeyati Poejiani, Rilia F Putri, Liliana Dewi, Hisanifa Arifani, Yatim L Ni'mah, Afaf Baktir
Biofilm-related infections play a significant role in the development and persistence of ventilator-associated pneumonia. Pseudomonas aeruginosa ( P. aeruginosa ) frequently causes biofilm-related infections associated with ventilator tubing. Glucosamine gold nanoparticles (AuNPs) may exhibit antibiofilm properties; however, more studies, including combinatorial therapy with antibiotics, are needed to explore their potential applications in clinical settings. This study aims to investigate the biofilm inhibition properties of glucosamine AuNPs in combination with meropenem against P...
March 31, 2024: Materials
Oladapo F Fagbohun, Wasitha P D W Thilakarathna, Juan Zhou, Christian Lehmann, Guangling Jiao, H P Vasantha Rupasinghe
Acute lung injury (ALI) represents a life-threatening condition with high morbidity and mortality despite modern mechanical ventilators and multiple pharmacological strategies. Therefore, there is a need to develop efficacious interventions with minimal side effects. The anti-inflammatory activities of sea cucumber ( Cucumaria frondosa ) and wild blueberry ( Vaccinium angustifolium ) extracts have been reported recently. However, their anti-inflammatory activities and the mechanism of action against ALI are not fully elucidated...
March 28, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Paula Marasovic, Dragana Kopitar, Tomislava Peremin-Volf, Marcela Andreata-Koren
Numerous research showed that mulching with conventional agro foils elevates soil temperature and promotes plant growth, but negatively influences soil health and brings environmental concerns. Most of the published research on nonwoven mulches for plant cultivation includes nonwoven fabrics produced by extrusion processes providing nonwoven fabric structures similar to films. A limited number of studies investigate the impact of nonwoven mulches produced by a mechanical process on the cards and bonded by needling on plant cultivation...
April 8, 2024: Polymers
Dhruv Patel, Anthony Devivo, Evan Leibner, Atinuke Shittu, Usha Govindarajulu, Pranai Tandon, David Lee, Randall Owen, Gustavo Fernandez-Ranvier, Robert Hiensch, Michael Marin, Roopa Kohli-Seth, Adel Bassily-Marcus
Background: New York City was the epicenter of the initial surge of the COVID-19 pandemic in the United States. Tracheostomy is a critical procedure in the care of patients with COVID-19. We hypothesized that early tracheostomy would decrease the length of time on sedation, time on mechanical ventilation, intensive care unit length of stay, and mortality. Methods: A retrospective analysis of outcomes for all patients with COVID-19 who underwent tracheostomy during the first year of the COVID-19 pandemic at the Mount Sinai Hospital in New York City, New York...
April 7, 2024: Journal of Clinical Medicine
Koray Durak, Katharina Nubbemeyer, Rashad Zayat, Jan Spillner, Slavena Dineva, Sebastian Kalverkamp, Alexander Kersten
Background : Abnormal liver function tests can identify severe cardiopulmonary failure. The aspartate transaminase/alanine transaminase (AST/ALT) ratio, or the De Ritis ratio, is commonly used to evaluate acute liver damage. However, its prognostic value in pulmonary embolism (PE) is unknown. Methods : Two cohorts, including patients with intermediate- and high-risk PEs, were established: one with an abnormal baseline AST/ALT ratio (>1) and another with a normal baseline AST/ALT ratio (<1). The primary outcome was a 60-day mortality...
April 4, 2024: Journal of Clinical Medicine
Emanuele Varaldo, Francesca Rumbolo, Nunzia Prencipe, Fabio Bioletto, Fabio Settanni, Giulio Mengozzi, Silvia Grottoli, Ezio Ghigo, Luca Brazzi, Giorgia Montrucchio, Alessandro Maria Berton
Objective: To investigate whether copeptin, MR-proADM and MR-proANP, alone or integrated with the SOFA, MuLBSTA and SAPS II scores, are capable of early recognition of COVID-19 ICU patients at increased risk of adverse outcomes. Methods: For this predefined secondary analysis of a larger cohort previously described, all consecutive COVID-19 adult patients admitted between March and December 2020 to the ICU of a referral, university hospital in Northern Italy were screened, and clinical severity scores were calculated upon admission...
March 30, 2024: Journal of Clinical Medicine
Tamás Dolinay, Lillian Hsu, Abigail Maller, Brandon Corbett Walsh, Attila Szűcs, Jih-Shuin Jerng, Dale Jun
Patients requiring mechanical ventilation (MV) beyond 21 days, usually referred to as prolonged MV, represent a unique group with significant medical needs and a generally poor prognosis. Research suggests that approximately 10% of all MV patients will need prolonged ventilatory care, and that number will continue to rise. Although we have extensive knowledge of MV in the acute care setting, less is known about care in the post-ICU setting. More than 50% of patients who were deemed unweanable in the ICU will be liberated from MV in the post-acute setting...
March 26, 2024: Journal of Clinical Medicine
Frédéric Martino, Antoine Fleuri, Nicolas Engrand, Amélie Rolle, Michel Piotin, Michel Carles, Delphine Delta, Laurent Do, Adrien Pons, Patrick Portecop, Mathys Sitcharn, Marc Valette, Laurent Camous, Jean-David Pommier, Alexandre Demoule
BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) is preferentially treated by prompt endovascular coiling, which is not available in Guadeloupe. Subsequently, patients are transferred to Paris, France mainland, by commercial airplane (6751 km flight) after being managed according to guidelines. This study describes the characteristics, management and outcomes related to these patients. METHODS: Retrospective observational cohort study of 148 patients admitted in intensive care unit for a suspected aSAH and transferred by airplane over a 10-year period (2010-2019)...
April 12, 2024: BMC Anesthesiology
Wenwen Li, Ranran Zhao, Shanshan Liu, Chengming Ma, Xianyao Wan
BACKGROUND: The effects of vitamin C supplementation on patients with septic shock remain controversial. We aimed to evaluate the effects of different vitamin C dosages on norepinephrine (NE) synthesis in adult patients with septic shock. METHODS: A total of 58 patients with septic shock admitted to our intensive care unit (ICU) between July 2021 and December 2022 were included. Patients were randomly divided into 3 groups: high-dose vitamin C (150 mg/kg/d, group A), low-dose vitamin C (50 mg/kg/d, group B), and placebo (group C)...
April 12, 2024: Medicine (Baltimore)
Bhavna Gupta, Deepak Singla, Anish Gupta, Ranjay Mahaseth
Postoperative visual loss (POVL) is an infrequent yet consequential complication that can follow cardiac surgical interventions. This systematic review aims to provide a comprehensive analysis of the incidence of POVL after cardiac surgery and to delineate the associated risk factors. A comprehensive search was conducted in major medical databases for relevant studies published up to September 2022. Eligible studies reporting on the incidence of POVL and identifying risk factors in patients undergoing cardiac surgery were included...
April 1, 2024: Annals of Cardiac Anaesthesia
Markus Bauswein, Ehab Eid, Lisa Eidenschink, Barbara Schmidt, André Gessner, Dennis Tappe, Dániel Cadar, Merle M Böhmer, Laura Jockel, Nora van Wickeren, Tamara Garibashvili, Isabel Wiesinger, Christina Wendl, Josef G Heckmann, Klemens Angstwurm, Martin Freyer
BACKGROUND: Within endemic regions in southern and eastern Germany, Borna disease virus 1 (BoDV-1) causes rare zoonotic spill-over infections in humans, leading to encephalitis with a high case-fatality risk. So far, intra-vitam diagnosis has mainly been based on RT-qPCR from cerebrospinal fluid (CSF) and serology, both being associated with diagnostic challenges. Whilst low RNA copy numbers in CSF limit the sensitivity of RT-qPCR from this material, seroconversion often occurs late during the course of the disease...
April 12, 2024: Infection
Lauren E Mazur, Katelyn M Even, Conrad Krawiec
Children with neurodevelopmental disorders are at risk for burn injury, but the clinical outcomes, particularly mortality, are unknown in this patient population in the United States (U.S.). The main objectives of this study are to evaluate (1) subject characteristics; (2) burn injury type; (3) clinical care provided; and (4) mortality in children with autism spectrum disorder (ASD), hypothesizing that this patient population has similar mortality and critical care management requirements when compared to children without ASD...
April 12, 2024: Journal of Autism and Developmental Disorders
Jukka Kopra, Erik Litonius, Pirkka T Pekkarinen, Merja Laitinen, Juho A Heinonen, Luca Fontanelli, Markus B Skrifvars
BACKGROUND: In refractory out-of-hospital cardiac arrest, the patient is commonly transported to hospital with mechanical continuous chest compressions (CCC). Limited data are available on the optimal ventilation strategy. Accordingly, we compared arterial oxygenation and haemodynamics during manual asynchronous continuous ventilation and compressions with a 30:2 compression-to-ventilation ratio together with the use of 10 cmH2 O positive end-expiratory pressure (PEEP). METHODS: Intubated and anaesthetized landrace pigs with electrically induced ventricular fibrillation were left untreated for 5 min (n = 31, weight ca...
April 12, 2024: Intensive Care Medicine Experimental
Yang Chen, Tingting Cheng, Huaping Zhu, Shiwen Xia
BACKGROUND: Extremely premature infants (EPIs) are those less than 32 weeks of gestational age. Preterm birth is the leading cause of neonatal death and poor prognosis, accounting for 25% of neonatal deaths, with extremely premature births accounting for 50% of all premature deaths. Continuous quality improvement (CQI) improves patient outcomes by changing and optimizing clinical practice including increasing participation of neonatologists in prenatal consultation, maintenance of normal body temperature in preterm infants, early use of pulmonary surfactant, reduction of mechanical ventilation time and intensive breastfeeding to reduce clinically avoidable adverse events...
April 12, 2024: Alternative Therapies in Health and Medicine
Frank Fox, Jessica Hayes, Barbara Whelan, Dympna Casey, Máire Connolly
OBJECTIVES: Future pandemics may cause more severe respiratory illness in younger age groups than COVID-19, requiring many more mechanical ventilators. This publication synthesizes the experiences of diverse contributors to Medtronic's mechanical ventilator supply chain during the pandemic, serving as a record of what worked and what didn't, while identifying key factors affecting production ramp-up in this healthcare crisis. METHOD: In-depth, one-on-one interviews (n = 17) were held with key Medtronic personnel and suppliers...
April 12, 2024: Disaster Medicine and Public Health Preparedness
Xiao Tang, Xiao-Li Xu, Na Wan, Yu Zhao, Rui Wang, Xu-Yan Li, Ying Li, Li Wang, Hai-Chao Li, Yue Gu, Chun-Yan Zhang, Qi Yang, Zhao-Hui Tong, Bing Sun
INTRODUCTION: Systematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS). METHOD: This was a single-center, prospective, cohort study. Survivors were followed up for four times after discharge from intensive care unit (ICU) by lung high-resolution computed tomography (HRCT), pulmonary function assessment, 6-minute walk test (6MWT), and SF-36 instrument...
2024: Frontiers in Cellular and Infection Microbiology
Abiu Sempere, Ibai Los-Arcos, Judith Sacanell, Cristina Berastegui, David Campany-Herrero, Jaume Vima, María Teresa Martín-Gómez, Leire Sánchez, Daniel Martínez-González, Carles Bravo, Oscar Len, Joan Gavaldà
Inhaled tobramycin treatment has been associated with nephrotoxicity in some case reports, but limited data are available about serum levels and its possible systemic absorption in lung transplant recipients (LTR). We conducted a single-center, observational and retrospective study of all adult (>18 years old) LTR treated with inhaled tobramycin for at least 3 days between June 2019 and February 2022. Trough serum levels were collected and >2 μg/mL was considered a high drug level...
2024: Transplant International
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