Mahnaz Yadollahi, Amir Hossein Shams, Mojtaba Norouzi, Monireh Feizi
Background: Pneumonia is the most common nosocomial infection reported worldwide in intensive care units. This study aimed to evaluate the risk factors of nosocomial pneumonia and the frequency of antibiotic resistance in trauma patients who need immediate intervention. Patients and Methods: This prospective cohort study was conducted in Shahid Rajaei Trauma Hospital in Shiraz between 2020 and 2021. All the trauma patients who needed immediate intervention (levels 1 and 2 based on the Canadian Emergency Department Triage and Acuity Scale) and had no symptoms of infection were included...
March 22, 2023: Surgical Infections
L Mense, T Hansmann, B Seipolt, M Kaufmann, M Rüdiger
AIM: Whereas there is agreement, that surfactant should be administered without mechanical ventilation, there is still a debate concerning the optimal method. DD-SURF combines the benefits of INSURE and less invasive surfactant administration (LISA). The efficacy of this approach has not been evaluated yet. METHODS: Retrospective cohort study of all preterm newborns below 300/7 weeks gestational age admitted to the neonatal intensive care unit. Data on surfactant therapy, respiratory support during the first 96 hours of life and neonatal morbidities until hospital discharge were collected from the electronic patient charts to evaluate the efficacy and safety of our approach...
March 22, 2023: Acta Paediatrica
Yuan-Hong Yuan, Hui Zhang, Zheng-Hui Xiao, Xiu-Lan Lu, Zhi-Yue Xu, Xin-Ping Zhang, Xia-Yan Kang, Xiao-Ping Zhao, Li-Fen Zhu
OBJECTIVES: To study the application value of transport ventilator in the inter-hospital transport of critically ill children. METHODS: The critically ill children in Hunan Children's Hospital who were transported with or without a transport ventilator were included as the observation group (from January 2019 to January 2020; n =122) and the control group (from January 2018 to January 2019; n =120), respectively. The two groups were compared in terms of general data, the changes in heart rate, respiratory rate, and blood oxygen saturation during transport, the incidence rates of adverse events, and outcomes...
March 15, 2023: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Şahender Gülbin Aygencel Bıkmaz, Onur Gökçe, Meryem Merve Haşimoğlu, Nazlıhan Boyacı, Melda Türkoğlu, Zeynep Arzu Yeğin, Zübeyde Nur Özkurt, Abdullah Münci Yağcı
BACKGROUND: Patients with hematological malignancies (HM) often require admission to the intensive care unit (ICU) due to organ failure, disease progression or treatment-related complications, and they generally have a poor prognosis. Therefore, understanding the factors affecting ICU mortality in HM patients is important. In this study, we aimed to identify the risk factors for ICU mortality in our critically ill HM patients. METHODS: We retrospectively reviewed the medical records of HM patients who were hospitalized in our medical ICU between January 1, 2010 and December 31, 2018...
February 2023: Turkish Journal of Medical Sciences
Tomohide Takei, Tatsuya Kida, Yutaka Usuda
Patients with a Blom® tracheostomy tube (containing a cuff) can vocalize while on mechanical ventilation, which can significantly improve the patient's quality of life. This is brought by the purpose-built structure of the tracheostomy tube that allows the expiration to be expelled through the glottis. However, this characteristic may complicate the measurement of the patient's tidal volume, as most of the expiration does not return to the ventilator. Owing to the necessity of insertion of the speech cannula, which acts as an inner cannula, to enable patient vocalization, the air passage likely becomes constricted, thus increasing airway resistance...
March 2023: Curēus
Mônica Rodrigues da Cruz, Luciana Moisés Camilo, Tiago Batista da Costa Xavier, Gabriel Casulari da Motta Ribeiro, Denise Machado Medeiros, Luís Felipe da Fonseca Reis, Bruno Leonardo da Silva Guimarães, André Miguel Japiassú, Alysson Roncally Silva Carvalho
BACKGROUND: The profile of changes in airway driving pressure (dPaw ) induced by positive-end expiratory pressure (PEEP) might aid for individualized protective ventilation. Our aim was to describe the dPaw versus PEEP curves behavior in ARDS from COVID-19 patients. METHODS: Patients admitted in three hospitals were ventilated with fraction of inspired oxygen (FiO2 ) and PEEP initially adjusted by oxygenation-based table. Thereafter, PEEP was reduced from 20 until 6 cmH2 O while dPaw was stepwise recorded and the lowest PEEP that minimized dPaw (PEEPmin_dPaw ) was assessed...
March 21, 2023: Critical Care: the Official Journal of the Critical Care Forum
Nicolas Delvau, Andrea Penaloza, Véronique Franssen, Frédéric Thys, Pierre-Marie Roy, Philippe Hantson
BACKGROUND: Cardiac arrest (CA) following CO poisoning (CO-induced CA) exposes patients to an extremely high risk of mortality and remains challenging to treat effectively. Terminal carboxyhemoglobin elimination half-life (COHbt1/2 ) is critically affected by ventilation, oxygen therapy, and cardiac output, which are severely affected conditions in cases of CA. CASE PRESENTATION: Asystole occurred in an 18-year-old woman after unintentional exposure to CO in her bathroom...
March 21, 2023: International Journal of Emergency Medicine
Samsani Veena Sudeepthi, Abinaya Kannan, Atul Jindal, Anudita Bhargava
This ambispective observational study, was conducted at a tertiary care centre in Central India. Children aged <16 y who tested positive for SARS-CoV2 between 1st April 2020 to 30th April 2022 were included. The prevalence of coronavirus disease-19 (COVID-19) infection was 1.2%. Of 525 children, median age was 60 mo; 88 (16.7%) were infants. Comorbidities were noted in 89 (16.9%) children. About 59% (n=309) were asymptomatic. Among symptomatic (n=216) children, fever (57.9%) was the most common symptom followed by cough (37%), running nose (21...
March 22, 2023: Indian Journal of Pediatrics
Yeqiu Li, Ting Wu, Cheng Guo
Ischemia/reperfusion (I/R) injury is the leading cause of death following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). γδT cells are suggested to aggravate blood-brain barrier (BBB) injury in various pathological processes. We herein investigate the effects of γδT cells inhibitor (UC7-13D5) against I/R injury post-CA/CPR. C57BL/6 mice were subjected to CA through injection of KCL (70 μL of 0.5 mol/L) and cessation of mechanical ventilation followed by CPR. Flow cytometry was performed to measure the proportion of CD3-positive cells after intraperitoneal injection of 200 μg UC7-13D5 at 6 h, 24 h, and 48 h post-resuscitation into mice...
March 21, 2023: Molecular Biotechnology
Wanting Li, Huiyue Zhang, Xianghui Huang, Ruming Ye, Ying Lin
Even though the stress secondary to invasive procedures has been investigated, less attention has been paid to the stimulation or pain caused by routine procedures on neonates. The changes in salivary cortisol concentration in mechanically ventilated NICU patients during routine procedures were monitored to provide reference and guidance for pain management. 80 mechanically ventilated neonates in the hospital from Sep 2021 to Mar 2022 were selected. The salivary cortisol levels of the neonates were monitored during nursing procedures and were categorized by their risk levels to the following groups: high-risk (endotracheal suctioning and arterial blood sampling), moderate-risk (gastric tube insertion, venipuncture), and low-risk (bedside bathing and diaper changes)...
March 21, 2023: Scientific Reports
Kevin W Gibbs, Jonathan L Forbes, Kelsey Harrison, Jennifer T W Krall, Aubrae Isenhart, Stephanie P Taylor, R Shayn Martin, Nathaniel S O'Connell, Rita N Bakhru, Jessica A Palakshappa, D Clark Files
BACKGROUND: Patient triggered Adaptive Pressure Control (APC-CMV) has been widely adopted as an alternative ventilator mode to patient-triggered Volume control (VC-CMV). However, the comparative effectiveness of the two ventilator modes remain uncertain. RESEARCH QUESTION: We sought to explore clinical and implementation factors pertinent to a future definitive RCT assessing APC-CMV vs VC-CMV as an initial ventilator mode strategy. The research objectives in our pilot trial test clinician adherence and explore clinical outcomes...
March 21, 2023: Respiratory Care
Xiao-Yu Jia, Xu-Ru Wang, Yan-Yu Jiang, Ming-Zi An, Da-Qing Pei, Zhen-Ping Li, Qing-He Zhou
BACKGROUND: In adults undergoing noncardiac surgery, the correlation between intraoperative tidal volume and postoperative acute kidney injury (AKI) is unclear. This study aimed to investigate the effects of low tidal volume ventilation on the incidence of postoperative AKI compared with conventional tidal volume in adults undergoing noncardiac surgery. METHODS: This was a two-center prospective randomized controlled trial on adult patients who underwent noncardiac surgery and had a mechanical ventilation of >60 min...
March 21, 2023: Minerva Anestesiologica
Pilan Jaipanya, Thamrong Lertudomphonwanit, Pongsthorn Chanplakorn, Picharn Pichyangkul, Chaiwat Kraiwattanapong, Gun Keorochana, Pittavat Leelapattana
PURPOSE: Spinal metastasis surgeries carry substantial risk of complications. PRF is among complications that significantly increase mortality rate and length of hospital stay. The risk factor of PRF after spinal metastasis surgery has not been investigated. This study aims to identify the predictors of postoperative respiratory failure (PRF) and in-hospital death after spinal metastasis surgery. METHODS: We retrospectively reviewed consecutive patients with spinal metastasis surgically treated between 2008 and 2018...
March 21, 2023: European Spine Journal
Ravindranath Tiruvoipati, Bindu Akkanti, Kha Dinh, Nicholas Barrett, Alexandra May, Jeremy Kimmel, Steven A Conrad
OBJECTIVES: Extracorporeal carbon dioxide removal (ECCO2R) devices are effective in reducing hypercapnia and mechanical ventilation support but have not been shown to reduce mortality. This may be due to case selection, device performance, familiarity, or the management. The objective of this study is to investigate the effectiveness and safety of a single ECCO2R device (Hemolung) in patients with acute respiratory failure and identify variables associated with survival that could help case selection in clinical practice as well as future research...
March 21, 2023: Critical Care Medicine
Pierre-François Dequin, Ferhat Meziani, Jean-Pierre Quenot, Toufik Kamel, Jean-Damien Ricard, Julio Badie, Jean Reignier, Nicholas Heming, Gaëtan Plantefève, Bertrand Souweine, Guillaume Voiriot, Gwenhaël Colin, Jean-Pierre Frat, Jean-Paul Mira, Nicolas Barbarot, Bruno François, Guillaume Louis, Sébastien Gibot, Christophe Guitton, Christophe Giacardi, Sami Hraiech, Sylvie Vimeux, Erwan L'Her, Henri Faure, Jean-Etienne Herbrecht, Camille Bouisse, Aurélie Joret, Nicolas Terzi, Arnaud Gacouin, Charlotte Quentin, Mercé Jourdain, Marie Leclerc, Carine Coffre, Hélène Bourgoin, Céline Lengellé, Caroline Caille-Fénérol, Bruno Giraudeau, Amélie Le Gouge
BACKGROUND: Whether the antiinflammatory and immunomodulatory effects of glucocorticoids may decrease mortality among patients with severe community-acquired pneumonia is unclear. METHODS: In this phase 3, multicenter, double-blind, randomized, controlled trial, we assigned adults who had been admitted to the intensive care unit (ICU) for severe community-acquired pneumonia to receive intravenous hydrocortisone (200 mg daily for either 4 or 8 days as determined by clinical improvement, followed by tapering for a total of 8 or 14 days) or to receive placebo...
March 21, 2023: New England Journal of Medicine
Rebecca Osborn, Maha Alamri, Rade Tomic, Michael G Ison
BACKGROUND: Lung transplantation is one of the only options for patients with severe COVID-19-associated lung injury (CALI). Studies on patients who received a lung transplant for CALI have, to date, not looked at the infectious outcomes. METHODS: After IRB approval, a retrospective case-control cohort study, matched 1:1, collected data on patients who underwent lung transplantation for CALI (case) and for non-COVID-19 end-stage lung disease (control) between June 1, 2020 and April 1, 2022 at a large academic hospital in Chicago...
March 21, 2023: Clinical Infectious Diseases
Yanhui Mao, Honglei Xie, Jianzhou Liang, Junjie He, Jianlin Ren
To control the spread and transmission of airborne particles (especially SARS-CoV-2 coronavirus, recently) in the indoor environment, many control strategies have been employed. Comparisons of these strategies enable a reasonable choice for indoor environment control and cost-effectiveness. In this study, a series of experiments were conducted in a full-scale chamber to simulate a conference room. The control effects of four different strategies (a ventilation system (320 m3 /h) with and without a baffle, a specific type of portable air cleaner (400 m3 /h) and a specific type of desk air cleaner (DAC, 160 m3 /h)) on the transportation of particles of different sizes were studied...
April 2023: Atmospheric Pollution Research
Ufuk Vardar, Ayodeji Ilelaboye, Mukunthan Murthi, Ramtej Atluri, Dae Yong Park, Parnia Khamooshi, Pius E Ojemolon, Hafeez Shaka
Introduction Evidence suggests the COVID-19 (coronavirus disease 2019) pandemic highlighted well-known healthcare disparities. This study investigated racial disparities in patients with COVID-19-related hospitalizations utilizing the US (United States) National Inpatient Sample (NIS). Methodology This was a retrospective study conducted utilizing the NIS 2020 database. The NIS was searched for hospitalization of adult patients with COVID-19 infection as a principal diagnosis using ICD-10 (International Classification of Diseases, Tenth Revision) codes...
February 2023: Curēus
Atefeh Rezaeifar, Aliye Tabatabaee, Mansour Siavash, Mojtaba Akbari
BACKGROUND: Disturbed biochemical factors have been observed in viral infections including SARS, Ebola virus, and now COVID-19. This study aimed to evaluate the association between Calcium axis' derangements and hospital duration, ICU admission, mechanical ventilation, and death in patients with COVID-19. METHODS: 428 hospitalized patients with COVID-19 were included in this study. On the first day of admission, the patients were extensively evaluated for biochemical and hormonal factors and followed up until discharge/death...
2023: International Journal of Preventive Medicine
Sandra L Jackson, Jason P Block, Deborah B Rolka, Meda E Pavkov, Jennifer R Chevinsky, Akaki Lekiachvili, Thomas W Carton, Deepika Thacker, Joshua L Denson, Anuradha Paranjape, Michael D Kappelman, Tegan K Boehmer, Evelyn Twentyman
INTRODUCTION: Hypertension and diabetes are associated with increased COVID-19 severity, yet less is known about COVID-19 outcomes across levels of disease control for these conditions. METHODS: All adults aged ≥20 years with COVID-19 between March 1, 2020 and March 15, 2021 in 42 healthcare systems in National Patient-Centered Clinical Research Network were identified. RESULTS: Among 656,049 adults with COVID-19, 41% had hypertension, and 13% had diabetes...
September 2022: AJPM Focus
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