Peerapong Kamjai, Sivaporn Hemvimol, Narisa Kengtrong Bordeerat, Potjanee Srimanote, Pornpimon Angkasekwinai
Coronavirus disease 2019 (COVID-19), a highly contagious pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly and remains a challenge to global public health. COVID-19 patients manifest various symptoms from mild to severe cases with poor clinical outcomes. Prognostic values of novel markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and C-reactive protein to lymphocyte ratio (CLR) calculated from routine laboratory parameters have recently been reported to predict severe cases; however, whether this investigation can guide oxygen therapy in COVID-19 patients remains unclear...
2022: PloS One
Hui Jin Shin, Ji-Hoon Na, Hyunjoo Lee, Young-Mock Lee
BACKGROUND: This study investigated the efficacy and safety of nusinersen, an antisense oligonucleotide, in patients with spinal muscular atrophy (SMA) types II (OMIM: 253,550) or III (OMIM: 253,400), including those with severe scoliosis or requiring respiratory support via mechanical ventilation. METHODS: Data from 40 patients with genetically confirmed SMA who were treated with nusinersen at our institute from March 2019 to April 2022 were retrospectively analyzed...
November 28, 2022: World Journal of Pediatrics: WJP
Rodrigo A Cornejo, Jorge Montoya, Abraham I J Gajardo, Jerónimo Graf, Leyla Alegría, Romyna Baghetti, Anita Irarrázaval, César Santis, Nicolás Pavez, Sofía Leighton, Vinko Tomicic, Daniel Morales, Carolina Ruiz, Pablo Navarrete, Patricio Vargas, Roberto Gálvez, Victoria Espinosa, Marioli Lazo, Rodrigo A Pérez-Araos, Osvaldo Garay, Patrick Sepúlveda, Edgardo Martinez, Alejandro Bruhn
BACKGROUND: Prone positioning is currently applied in time-limited daily sessions up to 24 h which determines that most patients require several sessions. Although longer prone sessions have been reported, there is scarce evidence about the feasibility and safety of such approach. We analyzed feasibility and safety of a continuous prolonged prone positioning strategy implemented nationwide, in a large cohort of COVID-19 patients in Chile. METHODS: Retrospective cohort study of mechanically ventilated COVID-19 patients with moderate-to-severe acute respiratory distress syndrome (ARDS), conducted in 15 Intensive Care Units, which adhered to a national protocol of continuous prone sessions  ≥ 48 h and until PaO2 :FiO2 increased above 200 mm Hg...
November 28, 2022: Annals of Intensive Care
H Elhedai, G S Arul, S Yong, P Nagakumar, H K Kanthimathinathan, I Jester, M Chaudhari, T J Jones, O Stumper, A N Seale
INTRODUCTION: Exomphalos is an anterior abdominal wall defect resulting in herniation of contents into the umbilical cord. Severe associated chromosomal anomalies and congenital heart disease (CHD) are known to influence mortality, but it is not clear which cardiac anomalies have the greatest impact on survival. METHODS: We performed a retrospective review of the treatment and outcome of patients with exomphalos over a 30-year period (1990-2020), with a focus on those with the combination of exomphalos major and major CHD (EMCHD)...
November 28, 2022: Pediatric Surgery International
Alain Lepape, Anaïs Machut, Cedric Bretonnière, Arnaud Friggeri, Charles-Hervé Vacheron, Anne Savey
OBJECTIVES: To compare the occurrence of healthcare-associated infections acquired in intensive care units (HAI-ICUs) in France among patients with COVID-19 and those without it in 2020 and the latter with that in patients before the COVID-19 pandemic. METHODS: Multicentre HAI-ICU surveillance network (REA-REZO) data were used to identify 3 groups: 2019 patients (2019Control), a COVID-19 group (2020Cov), and a non-COVID-19 group (2020NonCov). The primary outcome was the occurrence of HAI-ICU (ventilator-associated pneumonia [VAP], bloodstream infections [BSIs], catheter-related bacteraemia)...
October 28, 2022: Clinical Microbiology and Infection
Matthew K Wynia, Laurel E Beaty, Tellen D Bennett, Nichole E Carlson, Christopher B Davis, Bethany M Kwan, David A Mayer, Toan C Ong, Seth Russell, Jeffrey D Steele, Heather R Stocker, Adane F Wogu, Richard D Zane, Ronald J Sokol, Adit A Ginde
BACKGROUND: Neutralizing monoclonal antibodies (mAbs) were authorized for the treatment of COVID-19 outpatients based on clinical trials completed early in the pandemic, which were underpowered for mortality and subgroup analyses. Real-world data studies are promising for further assessing rapidly deployed therapeutics. RESEARCH QUESTION: Did mAb treatment prevent progression to severe disease and death across pandemic phases and based on risk factors, including prior vaccination status? STUDY DESIGN AND METHODS: This observational cohort study included nonhospitalized adult patients with SARS-CoV-2 infection from November 2020 to October 2021 using electronic health records from a statewide health system plus state-level vaccine and mortality data...
October 28, 2022: Chest
Pablo López Sanz, José Manuel Azaña Defez, Sara Plata Clemente, Claudia Guerrero Ramírez, Silvia Manso Córdoba
No abstract text is available yet for this article.
November 2022: Pediatric Dermatology
A Suárez-de-la-Rica, B Croes, L Ciudad, I Vallejo, J Mújica, M Díaz-Almirón, E Maseda
OBJECTIVE: This study aimed to evaluate whether early vitamin C and thiamine administration was associated with a lower 28-day and in-hospital mortality in surgical critically ill patients with refractory septic shock. METHODS: We performed a retrospective before-and-after study on patients with refractory septic shock. According to local protocol, hydrocortisone is initiated in case of refractory septic shock. In January 2017, the protocol was changed and vitamin C and thiamine were included...
November 28, 2022: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Laura A Ortmann, Aleisha Nabower, Melissa L Cullimore, Ellen Kerns
INTRODUCTION: Antibiotic use may shorten mechanical ventilation duration and length of stay for patients with bronchiolitis that require intubation. The goals of this study were to describe antibiotic use in previously healthy children with bronchiolitis admitted to the intensive care unit (ICU) for non-invasive respiratory support and to describe associations of early antibiotic use with clinical outcomes. METHODS: The Pediatric Health Information Systems database was queried for children <2 years of age without significant comorbidities admitted to the ICU for bronchiolitis...
November 28, 2022: Pediatric Pulmonology
Michael C Spaeder, J Randall Moorman, Liza P Moorman, Michelle A Adu-Darko, Jessica Keim-Malpass, Douglas E Lake, Matthew T Clark
Acute respiratory failure requiring the initiation of invasive mechanical ventilation remains commonplace in the pediatric intensive care unit (PICU). Early recognition of patients at risk for respiratory failure may provide clinicians with the opportunity to intervene and potentially improve outcomes. Through the development of a random forest model to identify patients at risk for requiring unplanned intubation, we tested the hypothesis that subtle signatures of illness are present in physiological and biochemical time series of PICU patients in the early stages of respiratory decompensation...
2022: Frontiers in Pediatrics
Constance S Harrell Shreckengost, Jorge Esteban Foianini, Karen Milenka Moron Encinas, Hugo Tola Guarachi, Katrina Abril, Dina Amin, David Berkowitz, Christine Aisha Castater, J Miller Douglas, April A Grant, Onkar Vohra Khullar, Andrea Nichole Lane, Alice Lin, Abesh Niroula, Azhar Nizam, Ammar Rashied, Alexandra W Reitz, Steven M Roser, Julia Spychalski, Sérgio Samir Arap, Ricardo Ferreira Bento, Pedro Prosperi Desenzi Ciaralo, Rui Imamura, Luiz Paulo Kowalski, Ali Mahmoud, Alessandro Wasum Mariani, Carlos Augusto Metidieri Menegozzo, Hélio Minamoto, Fábio Luiz M Montenegro, Paulo Manoel Pêgo-Fernandes, Jones Santos, Edivaldo Massozo Utiyama, Jithin K Sreedharan, Or Kalchiem-Dekel, Jonathan Nguyen, Rohan K Dhamsania, Kerianne Allen, Adrian Modzik, Vikas Pathak, Cheryl White, Juan Blas, Issa Talal El-Abur, Gabriel Tirado, Carlos Yánez Benítez, Thomas G Weiser, Mark Barry, Marissa Boeck, Michael Farrell, Anya Greenberg, Phoebe Miller, Paul Park, Maraya Camazine, Deidre Dillon, Randi N Smith
UNLABELLED: Timing of tracheostomy in patients with COVID-19 has attracted substantial attention. Initial guidelines recommended delaying or avoiding tracheostomy due to the potential for particle aerosolization and theoretical risk to providers. However, early tracheostomy could improve patient outcomes and alleviate resource shortages. This study compares outcomes in a diverse population of hospitalized COVID-19 patients who underwent tracheostomy either "early" (within 14 d of intubation) or "late" (more than 14 d after intubation)...
November 2022: Critical care explorations
João Cardoso, Ana Gaspar, Cristina Esteves
Leptospirosis is an infection caused by Leptospira . Leptospirosis causes disease in humans mainly in developing countries and also in countries with poor housing and sanitation, due to animals (mainly rats) that are potential sources of contamination. The clinical manifestations and the severity of leptospirosis are highly variable. We present the case of a 56-year-old female that was admitted to the emergency department with a three-week history of fever (38.4ºC), headache, dyspnea, and cough...
October 2022: Curēus
Abimbola O Ajibowo, Olasunkanmi A Kolawole, Haleema Sadia, Oyovwike S Amedu, Hassan A Chaudhry, Helai Hussaini, Eloho Hambolu, Tuba Khan, Humaira Kauser, Aadil Khan
Acute respiratory distress syndrome (ARDS) is an inflammatory process in the lungs that induces non-hydrostatic protein-rich pulmonary edema. ARDS occurs in roughly half of coronavirus disease 2019 (COVID-19) pneumonia patients, with most of them requiring intensive care. Oxygen saturation, partial pressure of the oxygen, and the fraction of the inspired oxygen are health indicators that may indicate a severe illness necessitating further investigation. As treatments have evolved, a typical pattern of ARDS has likewise evolved...
October 2022: Curēus
R Meierhans, H Gelpke, J Hetzel, C Madjdpour
Symptomatic tracheal stenosis is a rare but significant complication of long-term tracheal intubation and mechanical ventilation. Airway management for tracheal resection in severe tracheal stenosis, especially sequential stenoses, requires multidisciplinary planning. A valuable method of airway management is the insertion of a small-bore, cuffed tracheal tube (Tritube®, Ventinova Medical B.V., Eindhoven, The Netherlands) in combination with flow-controlled ventilation. In this case, a patient with tracheal stenosis following prolonged ventilation required resection of the stenosed tissue...
2022: Anaesthesia reports
Hannah M Bernstein, Brian Paciotti, Uma N Srivatsa
BACKGROUND: Atrial fibrillation (AF) has been reported to occur with coronavirus disease 2019 (COVID-19), but whether it is related to myocarditis or lung injury is unclear. OBJECTIVES: The purpose of this study was to compare incident AF in patients with pneumonia/adult respiratory distress syndrome (ARDS) with and without COVID. METHODS: This retrospective multicenter cohort study from 17 hospitals (March 2020 to December 2021) utilizing the University of California COVID Research Data Set (CORDS) included patients aged ≥18 years with primary diagnosis of pneumonia or ARDS during hospitalization...
October 31, 2022: Heart rhythm O2
Xiaoqian Li, Fan Huang, Lixia Zhu, Tianyi Luo, Yuzhuo Zhang, Huiwen Gu, Liheng Guo, Shuai Mao
Background: Septic shock has increasingly become a cause of death threatening human survival. Shenfu Injection (SFI), a patented Chinese medicine, has been widely used in the treatment of patients with sepsis and cardiovascular diseases domestically. We sought to examine whether combination therapy with SFI can improve clinical outcomes in critically ill patients undergoing mechanical ventilation (MV). Methods: This real-world, multicenter retrospective trial enrolled consecutive adult patients with sepsis requiring MV from four medical/surgical intensive care units (ICUs) in China between August 2016 and September 2021...
2022: Frontiers in Pharmacology
Zeead AlGhamdi, Shaya Y Alqahtani, Khalid AlDajani, Ammar Alsaedi, Omar Al-Rubaish, Abdulmajeed Alharbi, Hatem Elbawab
BACKGROUND: Previous studies have been conducted to assess pneumothorax. However, few studies were done to assess pneumothorax in COVID-19 patients in the intensive care unit (ICU). OBJECTIVE: Our aim is to describe and analyze the prevalence, clinical characteristics, risk factors, and outcomes of COVID-19 pneumothorax patients in the intensive care unit. METHODS: We performed a retrospective review of the medical records of 418 patients, who tested positive for COVID-19 by polymerase chain reaction test and required ICU admission in King Fahad Hospital of The University from 02/01/2020 to 01/09/2021...
2022: International Journal of General Medicine
Robert D Black, Eduardo Chaparro
Time-varying caloric vestibular stimulation (tvCVS) is a new form of non-invasive neuromodulation similar to, but different from, diagnostic caloric vestibular stimulation (CVS). Using a non-invasive, solid-state delivery device, tvCVS has been successfully used in a human clinical trial with Parkinson's disease (PD) subjects. Additionally, the effects of tvCVS on brain activation have been studied in healthy human subjects using transcranial Doppler sonography (TCD) and functional magnetic resonance imaging (BOLD fMRI)...
2022: Frontiers in Aging Neuroscience
Pranjal Vaidya, Mehdi Alilou, Amogh Hiremath, Amit Gupta, Kaustav Bera, Jennifer Furin, Keith Armitage, Robert Gilkeson, Lei Yuan, Pingfu Fu, Cheng Lu, Mengyao Ji, Anant Madabhushi
OBJECTIVE: The disease COVID-19 has caused a widespread global pandemic with ~3. 93 million deaths worldwide. In this work, we present three models-radiomics (MRM ), clinical (MCM ), and combined clinical-radiomics (MRCM ) nomogram to predict COVID-19-positive patients who will end up needing invasive mechanical ventilation from the baseline CT scans. METHODS: We performed a retrospective multicohort study of individuals with COVID-19-positive findings for a total of 897 patients from two different institutions (Renmin Hospital of Wuhan University, D1 = 787, and University Hospitals, US D2 = 110)...
2022: Front Radiol
Timothy G Foat, Benjamin Higgins, Charlotte Abbs, Thomas Maishman, Simon Coldrick, Adrian Kelsey, Matthew J Ivings, Simon T Parker, Catherine J Noakes
Computational fluid dynamics models have been developed to predict airborne exposure to the SARS-CoV-2 virus from a coughing person in a mechanically ventilated room. The models were run with three typical indoor air temperatures and relative humidities (RH). Quantile regression was used to indicate whether these have a statistically significant effect on the airborne exposure. Results suggest that evaporation is an important effect. Evaporation leads to respiratory particles, particularly those with initial diameters between 20 and 100 μm, remaining airborne for longer, traveling extended distances and carrying more viruses than expected from their final diameter...
November 2022: Indoor Air
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