Raphaela Garcia, Jorge I F Salluh, Teresa Raquel Andrade, Daniela Farah, Paulo S L da Silva, Danielle F Bastos, Marcelo C M Fonseca
PURPOSE: Compare outcomes of adult patients admitted to ICU- length of ICU stay, length of mechanical ventilation (MV), and time until extubation- according to the use of propofol versus midazolam. METHODS: We searched MEDLINE, EMBASE, LILACS, and Cochrane databases to retrieve RCTs that compared propofol and midazolam used as sedatives in adult ICU patients. We applied a random-effects, meta-analytic model in all calculations. We applied the Cochrane collaboration tool and GRADE...
April 6, 2021: Journal of Critical Care
Fahad Faqihi, Abdulrahman Alharthy, Salman Abdulaziz, Abdullah Balhamar, Awad Alomari, Zohair AlAseri, Hani Tamim, Saleh A Alqahtani, Demetrios J Kutsogiannis, Peter G Brindley, Dimitrios Karakitsos, Ziad A Memish
OBJECTIVE: To assess the efficacy of therapeutic plasma exchange (TPE) following life-threatening COVID-19. DESIGN, SETTING, AND PARTICIPANTS: Open-label, randomized clinical trial of intensive care unit (ICU) patients with life-threatening COVID-19 [positive real-time-polymerase-chain-reaction test, plus acute respiratory distress syndrome (ARDS), sepsis, organ failure, hyperinflammation]. The study was terminated after 87/120 patients were enrolled. INTERVENTION AND RANDOMIZATION: Standard treatment plus TPE (n = 43) versus standard treatment (n = 44), and stratified by peripheral arterial oxygen saturation/fraction of inspired oxygen (PaO2 /FiO2 ) ratio (> 150 versus ≤ 150)...
April 7, 2021: International Journal of Antimicrobial Agents
Yonni Friedlander, Brandon Zanette, Andras A Lindenmaier, Jordan Fliss, Daniel Li, Kiarash Emami, Robert P Jankov, Andrea Kassner, Giles Santyr
PURPOSE: To investigate the dependence of dissolved 129 Xe chemical shift on the fraction of inhaled oxygen, Fi O2 , in the lungs of healthy rats. METHODS: The chemical shifts of 129 Xe dissolved in red blood cells, δRBC , and blood plasma and/or tissue, δPlasma , were measured using MRS in 12 Sprague Dawley rats mechanically ventilated at Fi O2 values of 0.14, 0.19, and 0.22. Regional effects on the chemical shifts were controlled using a chemical shift saturation recovery sequence with a fixed delay time...
April 9, 2021: Magnetic Resonance in Medicine
Jaesh Naik, Laura Puzniak, Simone Critchlow, David Elsea, Ryan James Dillon, Joe Yang
INTRODUCTION: The clinical efficacy and safety of ceftolozane/tazobactam for the treatment of ventilated hospital-acquired bacterial pneumonia (vHABP) and ventilator-associated bacterial pneumonia (VABP) has been demonstrated in the phase III randomised controlled trial ASPECT-NP. However, there are no published data on the cost-effectiveness of ceftolozane/tazobactam for vHABP/VABP. These nosocomial infections are associated with high rates of morbidity and mortality, and are increasingly complicated by growing rates of resistance and the inappropriate use of antimicrobials...
April 9, 2021: Infectious Diseases and Therapy
Gregory Lui Duarte, Aldrin Lucas Bethiol, Ligia Dos Santos Roceto Ratti, Gabriel Franco, Rui Moreno, Rodrigo Marques Tonella, Antonio Luis Eiras Falcão
STUDY DESIGN: Retrospective case series. OBJECTIVES: To compare individuals with cervical spinal cord injury (SCI) submitted to transcutaneous electrical diaphragmatic stimulation (TEDS) or a standard weaning protocol (SWP) according to the following variables: invasive mechanical ventilation (IMV) time, ventilator weaning time, intensive care unit (ICU) length of stay, and overall hospital length of stay. SETTINGS: Tertiary university hospital...
April 9, 2021: Spinal Cord Series and Cases
Serhat Emeksiz, Serhan Özcan, Oktay Perk, Emel Uyar, Banu Çelikel Acar, Ayşe Esin Kibar Gül, Aslınur Özkaya Parlakay, Namık Özbek, Zahide Ekici Tekin, Serkan Coşkun, Fatma Aydın, Elif Çelikel, Ahmet Vedat Kavurt, İbrahim Ece, İkbal Ok Bozkaya, Ahmet Ertürk, Doğus Güney, Emrah Şenel
This study aimed to evaluate the effectiveness and the role of therapeutic plasma exchange (TPE) in treatment of children with severe MIS-C. In addition, we assessed demographic data, clinical features, laboratory abnormalities, underlying conditions, treatments, and outcomes. Patients with severe MIS-C who were admitted to the pediatric intensive care unit (PICU) between September 01 and October 05, 2020 were included in this observational, descriptive, retrospective study. The data collected included the patients' demographic data, presenting symptoms, clinical features, laboratory parameters, diagnostic investigations, and medications...
April 1, 2021: Transfusion and Apheresis Science
Pierre-Edouard Debureaux, Michael Darmon, Naïke Bige, Anne Sophie Moreau, Djamel Mokart, Guillaume Morel, Claire Lacan, Pierre Perez, Frédéric Pene, Achille Kouatchet, Muriel Picard, Martin Murgier, Florent Wallet, Julien Mayaux, Emmanuel Canet, Elie Azoulay, Sandrine Valade
Sinusoidal obstruction syndrome (SOS) is a life-threatening liver complication of high- dose chemotherapy. Defibrotide is the only available therapeutic option approved for SOS. The prognosis of SOS in patients requiring intensive care unit (ICU) admission remains unknown. The primary objective of this study was to assess the outcome of SOS patients in ICU. This retrospective study was conducted between 2007 and 2019 in 13 French ICUs. Seventy-one critically ill adult patients with SOS defined according to European Society for Blood and Marrow Transplantation criteria and treated with defibrotide were included...
April 2021: Transplantation and cellular therapy
Hideto Yasuda, Hiromu Okano, Takuya Mayumi, Chihiro Narita, Yu Onodera, Masaki Nakane, Nobuaki Shime
BACKGROUND: High-flow nasal cannula oxygenation (HFNC) and noninvasive positive-pressure ventilation (NPPV) possibly decrease tracheal reintubation rates better than conventional oxygen therapy (COT); however, few large-scale studies have compared HFNC and NPPV. We conducted a network meta-analysis (NMA) to compare the effectiveness of three post-extubation respiratory support devices (HFNC, NPPV, and COT) in reducing the mortality and reintubation risk. METHODS: The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and Ichushi databases were searched...
April 9, 2021: Critical Care: the Official Journal of the Critical Care Forum
Maria Tsikala Vafea, Raina Zhang, Markos Kalligeros, Evangelia K Mylona, Fadi Shehadeh, Eleftherios Mylonakis
INTRODUCTION: The use of mechanical ventilation associated with acute hypoxemic respiratory failure, the most common complication in critically ill COVID-19 patients, defines a high risk population that requires specific consideration of outcomes and treatment practices. AREAS COVERED: This review evaluates existing information about mortality rates and effectiveness of antiviral, immune-modulating, and anticoagulation treatments in COVID-19 patients who received mechanical ventilation...
April 9, 2021: Expert Review of Medical Devices
Qing Pan, Lingwei Zhang, Mengzhe Jia, Jie Pan, Qiang Gong, Yunfei Lu, Zhongheng Zhang, Huiqing Ge, Luping Fang
BACKGROUND AND OBJECTIVE: Patient-ventilator asynchrony (PVA) is the result of a mismatch between the need of patients and the assistance provided by the ventilator during mechanical ventilation. Because the poor interaction between the patient and the ventilator is associated with inferior clinical outcomes, effort should be made to identify and correct their occurrence. Deep learning has shown promising ability in PVA detection; however, lack of network interpretability hampers its application in clinic...
March 19, 2021: Computer Methods and Programs in Biomedicine
Scott A Helgeson, Augustine S Lee, Kaiser G Lim, Alexander S Niven, Neal M Patel
BACKGROUND: The Coronavirus pandemic has a high mortality rate in patients that are mechanically ventilated, which has led to an ever increasing interest in noninvasive forms of oxygenation. The use of these devices has the theoretical risk of increased exposure risk because of possible particulate generation. This study aimed to quantify the particulate generation associated with different oxygen devices. METHODS: This was a prospective single center study conducted during September 2020 using ten healthy adult volunteers...
April 2, 2021: Respiratory Medicine
Sandra Lopez-Castaneda, Nallely García-Larragoiti, Alan Cano-Mendez, Kenia Blancas-Ayala, Guadalupe Damian-Vázquez, Ana Itzel Perez-Medina, Luis David Chora-Hernández, Carlos Arean-Martínez, Martha Eva Viveros-Sandoval
Among COVID-19 hospitalized patients, high incidence of alterations in inflammatory and coagulation biomarkers correlates with a poor prognosis. Comorbidities such as chronic degenerative diseases are frequently associated with complications in COVID-19 patients. The aim of this study was to evaluate inflammatory and procoagulant biomarkers in COVID-19 patients from a public hospital in Mexico. Blood was sampled within the first 48 h after admission in 119 confirmed COVID-19 patients that were classified in 3 groups according to oxygen demand, evolution and the severity of the disease as follows: 1) Non severe: nasal cannula or oxygen mask; 2) Severe: high flow nasal cannula and 3) Death: mechanical ventilation eventually leading to fatal outcome...
January 2021: Clinical and Applied Thrombosis/hemostasis
Thiago Thomaz Mafort, Rogério Rufino, Claudia Henrique da Costa, Mariana Soares da Cal, Laura Braga Monnerat, Patrícia Frascari Litrento, Laura Lizeth Zuluaga Parra, Arthur de Sá Earp de Souza Marinho, Agnaldo José Lopes
BACKGROUND: The role of lung ultrasound (LUS) in evaluating the mid- and long-term prognoses of patients with COVID-19 pneumonia is not yet known. The objectives of this study were to evaluate associations between LUS signs at the time of screening and clinical outcomes 1 month after LUS and to assess LUS signs at the time of presentation with known risk factors for COVID-19 pneumonia. METHODS: This was a retrospective study of data prospectively collected 1 month after LUS screening of 447 adult patients diagnosed with COVID-19 pneumonia...
April 9, 2021: The ultrasound journal
Summit D Bloria, Nidhi B Panda, Kiran Jangra, Hemant Bhagat, Banashree Mandal, Ketan Kataria, Rajeev Chauhan, Ankur Luthra, Shiv Lal Soni, Narender Kaloria, Shalvi Mahajan, Shamik Kr Paul, Shailesh Gupta, Sanket Agrawal, Navneet Singla
BACKGROUND: Fluid imbalance is common after aneurysmal subarachnoid hemorrhage and negatively impacts clinical outcomes. We compared intraoperative goal-directed fluid therapy (GDFT) using left ventricular outflow tract velocity time integral (LVOT-VTI) measured by transesophageal echocardiography with central venous pressure (CVP)-guided fluid therapy during aneurysm clipping in aneurysmal subarachnoid hemorrhage patients. METHODS: Fifty adults scheduled for urgent craniotomy for aneurysm clipping were randomly allocated to 2 groups: group G (n=25) received GDFT guided by LVOT-VTI and group C (n=25) received CVP-guided fluid management...
April 8, 2021: Journal of Neurosurgical Anesthesiology
Yudan Wu, Meilan Liang, Meijing Wu, Qionge Fu, Cimei Zeng
OBJECTIVE: To observe the application effect of respiratory stepwise management in patients with septic shock combined with acute lung injury (ALI). METHODS: 100 patients with septic shock combined with ALI were selected as the research objects in Haikou Hospital Affiliated to Xiangya Medical College of Central South University from January 2018 to June 2020. Fifty patients were given endotracheal intubation or invasive ventilation on the basis of conventional treatment (conventional treatment group)...
March 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Guangyu Lyu, Tianbin Cai, Wenfang Jiang, Meiqiong Liu, Xiaoyuan Wang
OBJECTIVE: To observe the effects of veno-venous extracorporeal membrane oxygenation (VV-ECMO) combined with prone position ventilation (PPV) on oxygenation index (PaO2 /FiO2 ), respiratory compliance (Crs) and vasoactive inotropic score (VIS) in severe acute respiratory distress syndrome (ARDS) patients. METHODS: Eighteen patients with severe ARDS requiring VV-ECMO support in Liuzhou People's Hospital from June 2018 to April 2020 were selected for retrospective analysis, and 8 patients among of these cases received PPV after VV-ECMO...
March 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Jiahui Dong, Lingling Wang, Richeng Xiong, Xing Liu, Zhenhui Guo, Weifeng Sun, Rui Chen
OBJECTIVE: To establish a 180-day mortality predictive score based on frailty syndrome in elderly sepsis patients [elderly sepsis score (ESS)]. METHODS: A prospective study for sepsis patients aged 60 years and above who were admitted to a medical intensive care unit of the General Hospital of Southern Theatre Command from January 1st, 2018 to December 31st, 2018 was conducted. Univariate analysis was performed on 19 independent variables including gender, age, body mass index (BMI), tumor, charlson comorbidity index (CCI), activity of daily living (ADL), instrumental activity of daily living (IADL), mini-mental state examination (MMSE), geriatric depression scale (GDS), clinical frail scale (CFS), sequential organ failure assessment (SOFA), Glasgow coma scale (GCS), acute physiology and chronic health evaluation (APACHE II, APACHE IV), modified NUTRIC score (MNS), multiple drug resistance (MDR), mechanical ventilation (MV), continuous renal replacement therapy (CRRT) and palliative care...
March 2021: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Marietou Daou, Claire Lauzon, E Caroline Bullen, Irene Telias, Eddy Fan, M Elizabeth Wilcox
Objectives: To assess differences in cognitive outcomes and sleep in adult survivors of critical illness, managed with venovenous extracorporeal membrane oxygenation as compared to conventional mechanical ventilation only. Design: Retrospective cohort study linked with data from the COGnitive outcomes and WELLness study. Setting: A multisite study from five adult medical/surgical ICUs in Toronto. Patients: Thirty-three ICU survivors including adult patients who received venovenous extracorporeal membrane oxygenation ( n = 11) matched with patients who received mechanical ventilation only ( n = 22) using specified covariates (e...
April 2021: Critical care explorations
Harold Julius Augustus Oglesby, Steven H Cataldo, Michael J Pedro
Objectives: Critical care teams are encouraged to follow best practice protocols to help wean mechanically ventilated patients from the ventilator to reduce ventilator-associated events including ventilator-associated conditions, probable ventilator-associated pneumonias, and infection-related ventilator-associated conditions. Providers monitor for alerts suggestive of possible ventilator-associated events and advise when patients should undergo spontaneous breathing trials. Compliance with protocols in most units is suboptimal...
April 2021: Critical care explorations
Behnam Sobouti, Mostafa Dahmardehei, Shahrzad Fallah, Majid Karrobi, Yaser Ghavami, Reza Vaghardoost
Background and Purpose: Despite advances in burn care and management, infections are still a major contributor to morbidity and mortality rates in patients with burn injuries. Regarding this, the present study was conducted to investigate the prevalence and importance of candidemia in pediatric burn patients. Materials and Methods: Blood samples were collected from the patients and cultured in an automated blood culture system. Candida species were identified using specific culture media...
September 2020: Current Medical Mycology
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