Noriki Takahashi, Ryunosuke Nakashima, Aoi Nasu, Megumi Hayashi, Haruka Fujikawa, Taisei Kawakami, Yuka Eto, Tomoki Kishimoto, Ayami Fukuyama, Choyo Ogasawara, Keisuke Kawano, Yukio Fujiwara, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto
Chronic obstructive pulmonary disease (COPD) is a complex pulmonary condition characterized by bronchitis, emphysema, and mucus stasis. Due to the variability in symptoms among patients, traditional approaches to treating COPD as a singular disease are limited. This led us to focus on phenotype/endotype classifications. In this study, we explore the potential therapeutic role of thyroid hormone (T3 ) by using mouse models: emphysema-dominant elastase-induced COPD and airway-dominant C57BL/6-βENaC-Tg to represent different types of the disease...
December 22, 2023: Antioxidants (Basel, Switzerland)