keyword
https://read.qxmd.com/read/38533191/enhanced-strontium-removal-through-microbially-induced-carbonate-precipitation-by-indigenous-ureolytic-bacteria
#1
JOURNAL ARTICLE
Matthew White-Pettigrew, Samuel Shaw, Lewis Hughes, Christopher Boothman, James Graham, Liam Abrahamsen-Mills, Katherine Morris, Jonathan R Lloyd
Microbial ureolysis offers the potential to remove metals including Sr2+ as carbonate minerals via the generation of alkalinity coupled to NH4 + and HCO3 - production. Here, we investigated the potential for bacteria, indigenous to sediments representative of the U.K. Sellafield nuclear site where 90 Sr is present as a groundwater contaminant, to utilize urea in order to target Sr2+ -associated (Ca)CO3 formation in sediment microcosm studies. Strontium removal was enhanced in most sediments in the presence of urea only, coinciding with a significant pH increase...
March 21, 2024: ACS Earth & Space Chemistry
https://read.qxmd.com/read/38506992/ion-quantitation-in-liposomal-products-using-rp-hplc-with-charged-aerosol-detection
#2
JOURNAL ARTICLE
Jie Xu, Jeffrey D Clogston
Ion concentration in liposomal drugs is important for drug stability and drug release profile. However, quantifying ion concentration in liposomal drugs is challenging due to the absence of chromophores or fluorophores of ions and the efficiency of their release from the liposome structure. To address these issues, a method based on reversed-phase high-performance liquid chromatography (RP-HPLC) coupled with a charged aerosol detector (CAD) has been developed to determine total, internal, and external ions in drug-loaded liposomal products...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38496946/stearate-coated-biogenic-calcium-carbonate-from-waste-seashells-a-sustainable-plastic-filler
#3
JOURNAL ARTICLE
Maria Luisa Basile, Carla Triunfo, Stefanie Gärtner, Simona Fermani, Davide Laurenzi, Gabriele Maoloni, Martina Mazzon, Claudio Marzadori, Alessio Adamiano, Michele Iafisco, Devis Montroni, Jaime Gómez Morales, Helmut Cölfen, Giuseppe Falini
Waste seashells from aquaculture are a massive source of biogenic calcium carbonate (bCC) that can be a potential substitute for ground calcium carbonate and precipitated calcium carbonate. These last materials find several applications in industry after a surface coating with hydrophobic molecules, with stearate as the most used. Here, we investigate for the first time the capability of aqueous stearate dispersions to coat bCC powders from seashells of market-relevant mollusc aquaculture species, namely the oyster Crassostrea gigas , the scallop Pecten jacobaeus , and the clam Chamelea gallina ...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38496333/characterization-of-chemical-reactions-of-silver-diammine-fluoride-and-hydroxyapatite-under-remineralization-conditions
#4
JOURNAL ARTICLE
M Kaur, S Shahid, N Karpukhina, P Anderson, F S L Wong
INTRODUCTION: Silver Diammine Fluoride (SDF) is a clinically used topical agent to arrest dental caries. However, the kinetics of its chemical interactions with hydroxyapatite (HA), the principal inorganic component of dental enamel, are not known. The aim was to characterize the step-wise chemical interactions between SDF and HA powder during the clinically important process of remineralization. METHODS: Two grams of HA powder were immersed in 10 ml acetic acid pH = 4...
2024: Front Oral Health
https://read.qxmd.com/read/38496269/elucidating-the-anti-hypertensive-mechanisms-of-uncaria-rhynchophylla-alisma-plantago-aquatica-l-an-integrated-network-pharmacology-cluster-analysis-and-molecular-docking-approach
#5
JOURNAL ARTICLE
Tong Yin, Han Zhang, Xingfang Liu, Dongfeng Wei, Cong Ren, Liangyu Cui, Yukun Li, Linshuang Wang, Jiaheng Wang, Zhiwei Zhao, Dasheng Liu, Liying Wang, Xuejie Han
Background: With the increasing global prevalence of hypertension, a condition that can severely affect multiple organs, there is a growing need for effective treatment options. Uncaria rhynchophylla-Alisma plantago-aquatica L. (UR-AP) is a traditional drug pair used for treating hypertension based on the liver-kidney synergy concept. However, the detailed molecular mechanisms underlying its efficacy remain unclear. Methods: This study utilized an integrative approach combining network pharmacology, cluster analysis, and molecular docking to uncover the bioactive components and targets of UR-AP in the treatment of hypertension...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38494234/mechanical-activation-enhanced-metal-organic-coordination-strategy-to-fabricate-high-performance-starch-polyvinyl-alcohol-films-by-extrusion-blowing
#6
JOURNAL ARTICLE
Hongrui Wu, Wanhe Li, Zirong Liang, Tao Gan, Huayu Hu, Zuqiang Huang, Yuben Qin, Yanjuan Zhang
The production of high-performance starch-based packaging films by extrusion blowing is challenging, ascribed to poor processability of the blend precursors. In this study, a new strategy of mechanical activation (MA)-enhanced metal-organic coordination was proposed to improve the processability of starch (St)/polyvinyl alcohol (PVA) blend precursor, with calcium acetate (CA) as a chelating agent and glycerol as a plasticizer. MA pretreatment activated the hydroxyl groups of starch and PVA for constructing strong metal-organic coordination between CA and St/PVA during reactive extrusion, which effectively enhanced the melt processing properties of the blend precursor, contributing to the fabrication of high-performance St/PVA films by the extrusion-blowing method...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38473540/research-on-utilizable-calcium-from-calcium-carbide-slag-with-different-extractors-and-its-effect-on-co-2-mineralization
#7
JOURNAL ARTICLE
Yantao Ma, Xiang Zhang, Zhengyu Du, Haobo Hou, Yiguang Zheng
With the increasing accumulation of alkaline industrial solid waste, the mineralization of CO2 using alkaline industrial solid waste has broad application prospects. Carbide slag is highly alkaline and contains a large amount of calcium elements, making it an excellent material for CO2 mineralization. Our idea was to acquire qualified products and fast kinetics by integrating carbide slag utilization and carbon reduction. The reaction route was divided into two steps: calcium extraction and carbonization. In order to achieve efficient extraction of utilizable calcium, we selected NH4 Ac as the extraction agent, which has the advantage of buffer protection and environmental friendliness due to being an acetate radical...
February 26, 2024: Materials
https://read.qxmd.com/read/38471601/anionic-species-from-multivalent-metal-salt-solution-are-differentially-retained-during-ionic-gelation-and-could-fine-tune-alginate-hydrogel-properties
#8
JOURNAL ARTICLE
Subhasis Dash, Pavan Gutti, Birendra Behera, Debasish Mishra
The role of anionic counterions of divalent metal salts in alginate gelation and hydrogel properties has been thoroughly investigated. Three anions were selected from the Hofmeister series, namely sulphates, acetates and chlorides, paired in all permutations and combinations with divalent metals calcium, zinc and copper. Spectroscopic analysis revealed the presence of the anions and their interaction with the metal atoms after gelation. The data showed that gelation time and other hydrogel properties were largely controlled by the cations...
March 10, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38412277/tenapanor-xphozah-for-hyperphosphatemia-in-chronic-kidney-disease
#9
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 4, 2024: Medical Letter on Drugs and Therapeutics
https://read.qxmd.com/read/38402237/ffar2-expressing-myeloid-derived-suppressor-cells-drive-cancer-immunoevasion
#10
JOURNAL ARTICLE
Zeda Zhao, Juliang Qin, Ying Qian, Chenshen Huang, Xiaohong Liu, Ning Wang, Liqin Li, Yuqing Chao, Binghe Tan, Na Zhang, Min Qian, Dali Li, Mingyao Liu, Bing Du
BACKGROUND: Emerging evidences suggest that aberrant metabolites contributes to the immunosuppressive microenvironment that leads to cancer immune evasion. Among tumor immunosuppressive cells, myeloid-derived suppressor cells (MDSCs) are pathologically activated and extremely immunosuppressive, which are closely associated with poor clinical outcomes of cancer patients. However, the correlation between MDSCs mediated immunosuppression and particular cancer metabolism remained elusive...
February 24, 2024: Journal of Hematology & Oncology
https://read.qxmd.com/read/38329668/role-of-calcium-signaling-in-cadmium-stress-mitigation-by-indol-3-acetic-acid-and-gibberellin-in-chickpea-seedlings
#11
JOURNAL ARTICLE
Lamia Sakouhi, Muhammad Hussaan, Yoshiyuki Murata, Abdelilah Chaoui
Given the adverse impacts of heavy metals on plant development and physiological processes, the present research investigated the protective role of indole-3-acetic acid (IAA) and gibberellic acid (GA3) against cadmium (Cd)-induced injury in chickpea seedlings. Therefore, seeds germinated for 6 days in a medium containing 200 μM Cd alone or combined with 10 μM GA3 or 10 μM IAA. Both GA3 and IAA mitigated Cd-imposed growth delays in roots and shoots (80% and 50% increase in root and shoot length, respectively)...
February 8, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38311008/methods-for-studying-p2x4-receptor-ion-channels-in-immune-cells
#12
JOURNAL ARTICLE
Ronald Sluyter, Tahnee B-D McEwan, Reece A Sophocleous, Leanne Stokes
The P2X4 receptor is a trimeric ligand-gated ion channel activated by adenosine 5'-triphosphate (ATP). P2X4 is present in immune cells with emerging roles in inflammation and immunity, and related disorders. This review aims to provide an overview of the methods commonly used to study P2X4 in immune cells, focusing on those methods used to assess P2RX4 gene expression, the presence of the P2X4 protein, and P2X4 ion channel activity in these cells from humans, dogs, mice and rats. P2RX4 gene expression in immune cells is commonly assessed using semi-quantitative and quantitative reverse-transcriptase-PCR...
February 2, 2024: Journal of Immunological Methods
https://read.qxmd.com/read/38293916/role-of-protein-kinase-c-in-metabolic-regulation-of-coronary-endothelial-small-conductance-calcium-activated-potassium-channels
#13
JOURNAL ARTICLE
Hang Xing, Sharif A Sabe, Guangbin Shi, Dwight D Harris, Yuhong Liu, Frank W Sellke, Jun Feng
BACKGROUND: Small conductance calcium-activated potassium (SK) channels are largely responsible for endothelium-dependent coronary arteriolar relaxation. Endothelial SK channels are downregulated by the reduced form of nicotinamide adenine dinucleotide (NADH), which is increased in the setting of diabetes, yet the mechanisms of these changes are unclear. PKC (protein kinase C) is an important mediator of diabetes-induced coronary endothelial dysfunction. Thus, we aimed to determine whether NADH signaling downregulates endothelial SK channel function via PKC...
January 31, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38287700/effects-of-physical-form-of-%C3%AE-lactoglobulin-and-calcium-ingestion-on-glp-1-secretion-gastric-emptying-and-energy-intake-in-humans-a-randomised-crossover-trial
#14
JOURNAL ARTICLE
Jonathan D Watkins, Harry A Smith, Aaron Hengist, Søren B Nielsen, Ulla Ramer Mikkelsen, John Saunders, Francoise Koumanov, James A Betts, Javier T Gonzalez
The aim of this study was to assess whether adding Ca2+  to aggregate or native forms of β -lactoglobulin alters gut hormone secretion, gastric emptying rates and energy intake in healthy men and women. Fifteen healthy adults (mean ± sd: 9M/6F, age: 24 ± 5 years) completed four trials in a randomised, double-blind, crossover design. Participants consumed test drinks consisting of 30 g of β -lactoglobulin in a native form with (NATIVE + MINERALS) and without (NATIVE) a Ca2+ -rich mineral supplement and in an aggregated form both with (AGGREG + MINERALS) and without the mineral supplement (AGGREG)...
January 30, 2024: British Journal of Nutrition
https://read.qxmd.com/read/38265045/role-of-organic-and-inorganic-amendments-on-physiological-attributes-of-germinating-pea-seedlings-under-arsenic-stress
#15
JOURNAL ARTICLE
Marina Rafiq, Muhammad Shahid, Irshad Bibi, Sana Khalid, Tasveer Zahra Tariq, Abdullah A Al-Kahtani, Zeid A ALOthman, Behzad Murtaza, Nabeel Khan Niazi
There are scarce data regarding the effects of soil amendments on biophysicochemical responses of plants at the early stages of growth/germination. This study critically compares the effects of ethylene-diamine-tetra-acetic-acid (EDTA) and calcium (Ca) on biophysicochemical responses of germinating pea seedlings under varied arsenic levels (As, 25, 125, 250 µM). Arsenic alone enhanced hydrogen peroxide (H2 O2 ) level in pea roots (176%) and shoot (89%), which significantly reduced seed germination percentage, pigment contents, and growth parameters...
January 24, 2024: International Journal of Phytoremediation
https://read.qxmd.com/read/38264572/the-effect-of-retinol-acetate-on-liver-fibrosis-depends-on-the-temporal-features-of-the-development-of-pathology
#16
JOURNAL ARTICLE
Anatoly I Bozhkov, Rustam A Akzhyhitov, Svitlana G Bilovetska, Evgeny G Ivanov, Nataliia I Dobrianska, Anastasiia Yu Bondar
BACKGROUND: The effect of vitamin A on the manifestations of liver fibrosis is controversial and establishing the causes of its multidirectional influence is an urgent problem. In the work, the functional characteristics of the liver with Cu-induced fibrosis were determined after the restoration of vitamin A to the control level at the F0/F1 stage. METHODS: In animals with liver fibrosis, classical indicators of physiology, functional activity of the liver, histological, and hematological characteristics were determined; the content of calcium and ROS was determined in bone marrow cells...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38258379/porous-microneedles-through-direct-ink-drawing-with-nanocomposite-inks-for-transdermal-collection-of-interstitial-fluid
#17
JOURNAL ARTICLE
Yushuang Pang, Yanyan Li, Kerong Chen, Ming Wu, Jiaxue Zhang, Yuping Sun, Yurui Xu, Xiaoliang Wang, Qian Wang, Xinghai Ning, Desheng Kong
Interstitial fluid (ISF) is an attractive alternative to regular blood sampling for health checks and disease diagnosis. Porous microneedles (MNs) are well suited for collecting ISF in a minimally invasive manner. However, traditional methods of molding MNs from microfabricated templates involve prohibitive fabrication costs and fixed designs. To overcome these limitations, this study presents a facile and economical additive manufacturing approach to create porous MNs. Compared to traditional layerwise build sequences, direct ink drawing with nanocomposite inks can define sharp MNs with tailored shapes and achieve vastly improved fabrication efficiency...
January 23, 2024: Small
https://read.qxmd.com/read/38242697/alleviating-hypertension-by-selectively-targeting-angiotensin-receptor-expressing-vagal-sensory-neurons
#18
JOURNAL ARTICLE
Caitlin Baumer-Harrison, Khalid Elsaafien, Dominique N Johnson, Jesus D Peñaloza Aponte, Alan de Araujo, Sagar Patel, Erin Bruce, Scott W Harden, Charles J Frazier, Karen A Scott, Guillaume de Lartigue, Eric G Krause, Annette D de Kloet
Cardiovascular homeostasis is maintained, in part, by neural signals arising from arterial baroreceptors that apprise the brain of blood volume and pressure. Here, we test whether neurons within the nodose ganglia that express angiotensin type-1a receptors (referred to as NGAT1aR ) serve as baroreceptors that differentially influence blood pressure (BP) in male and female mice. Using Agtr1a -Cre mice and Cre-dependent AAVs to direct tdTomato to NGAT1aR , neuroanatomical studies revealed that NGAT1aR receive input from the aortic arch, project to the caudal nucleus of the solitary tract (NTS), and synthesize mechanosensitive ion channels, Piezo-1/-2 To evaluate the functionality of NGAT1aR , we directed the fluorescent calcium indicator (GCaMP6s) or the light-sensitive channelrhodopsin-2 (ChR2) to Agtr1a -containing neurons...
January 19, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38223297/phytochemical-properties-of-crataegus-azarolus-berries-decoction-extract-and-evaluation-of-its-protective-activity-against-acetic-acid-induced-ulcerative-colitis-in-rats
#19
JOURNAL ARTICLE
Houcem Sammari, Saber Jedidi, Houcine Selmi, Mourad Jridi, Ala Ayari, Hichem Sebai
The present study aims to evaluate the protective effect of Crataegus azarolus berries decoction extract (CAB-DE) against acetic acid-induced ulcerative colitis as well as the mechanisms implicated in such protection. Adult male Wistar rats were separated into seven groups: Control (H2 O), acetic acid (AA), AA + various doses of CAB-DE (100, 200, and 400 mg/kg, b.w.,p.o. ), and AA + sulfasalazine (100 mg/kg, b.w.,p.o. ) or gallic acid (50 mg/kg, b.w.,p.o. ) during 10 days. All rats were kept fasting overnight and ulcerative colitis was induced by rectal infusion of AA (300 mg kg-1 , b...
2024: Dose-response: a Publication of International Hormesis Society
https://read.qxmd.com/read/38217423/in-vitro-chemical-treatment-of-silk-increases-the-expression-of-pro-inflammatory-factors-and-facilitates-degradation-in-rats
#20
JOURNAL ARTICLE
Jinfeng Lv, Jieping Wang, Yao Zeng, Simeng Tian, Fei Wang, Yixue Zhai, Qian Zhou, Xiyue Luo, Xuanjie Zhang, Bin Liu, Chan Zhou
OBJECTIVES: Silk fiber is difficult to degrade in vivo, which limits its application in tissue engineering materials such as artificial nerves. Therefore, in this study aim to promote its degradation in vivo by chemical treating silk fibers in vitro. MATERIALS AND METHODS: Sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), scanning electron microscopy (SEM) observations, mechanical test, Fourier transform infrared spectroscopy (FT-IR) measurements were used to investigate the degradation effect of chemicals (hydrochloric acid, phosphoric acid, acetic acid, sodium hydroxide, calcium hydroxide, sodium bicarbonate, and calcium chloride) on silk fiber in vitro...
2024: Journal of Applied Biomaterials & Functional Materials
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