keyword
https://read.qxmd.com/read/38811906/responses-of-nutrient-utilization-rumen-fermentation-and-microorganisms-to-different-roughage-of-dairy-buffaloes
#41
JOURNAL ARTICLE
Shichun He, Ruiyun Zhang, Rongjiao Wang, Dongwang Wu, Sifan Dai, Zibei Wang, Tao Chen, Huaming Mao, Qing Li
Dairy buffaloes are typically fed a high-forage, low-quality diet with high fiber. These conditions result in an inherent energy and protein inefficiency. In order to make full and rational use of feed resources and improve the production level and breeding efficiency of dairy buffaloes, the effects of various roughages on nutrient digestibility, ruminal fermentation parameters, and microorganisms in dairy buffaloes were studied in this experiment. Three ternary hybrid buffaloes, with an average body weight of 365 ± 22...
May 29, 2024: BMC Microbiology
https://read.qxmd.com/read/38811842/systematic-decoding-of-cis-gene-regulation-defines-context-dependent-control-of-the-multi-gene-costimulatory-receptor-locus-in-human-t-cells
#42
JOURNAL ARTICLE
Cody T Mowery, Jacob W Freimer, Zeyu Chen, Salvador Casaní-Galdón, Jennifer M Umhoefer, Maya M Arce, Ketrin Gjoni, Bence Daniel, Katalin Sandor, Benjamin G Gowen, Vinh Nguyen, Dimitre R Simeonov, Christian M Garrido, Gemma L Curie, Ralf Schmidt, Zachary Steinhart, Ansuman T Satpathy, Katherine S Pollard, Jacob E Corn, Bradley E Bernstein, Chun Jimmie Ye, Alexander Marson
Cis-regulatory elements (CREs) interact with trans regulators to orchestrate gene expression, but how transcriptional regulation is coordinated in multi-gene loci has not been experimentally defined. We sought to characterize the CREs controlling dynamic expression of the adjacent costimulatory genes CD28, CTLA4 and ICOS, encoding regulators of T cell-mediated immunity. Tiling CRISPR interference (CRISPRi) screens in primary human T cells, both conventional and regulatory subsets, uncovered gene-, cell subset- and stimulation-specific CREs...
May 29, 2024: Nature Genetics
https://read.qxmd.com/read/38811591/development-of-a-novel-non-invasive-biomarker-panel-for-hepatic-fibrosis-in-masld
#43
JOURNAL ARTICLE
Lars Verschuren, Anne Linde Mak, Arianne van Koppen, Serdar Özsezen, Sonia Difrancesco, Martien P M Caspers, Jessica Snabel, David van der Meer, Anne-Marieke van Dijk, Elias Badal Rashu, Puria Nabilou, Mikkel Parsberg Werge, Koen van Son, Robert Kleemann, Amanda J Kiliaan, Eric J Hazebroek, André Boonstra, Willem P Brouwer, Michail Doukas, Saurabh Gupta, Cornelis Kluft, Max Nieuwdorp, Joanne Verheij, Lise Lotte Gluud, Adriaan G Holleboom, Maarten E Tushuizen, Roeland Hanemaaijer
Accurate non-invasive biomarkers to diagnose metabolic dysfunction-associated steatotic liver disease (MASLD)-related fibrosis are urgently needed. This study applies a translational approach to develop a blood-based biomarker panel for fibrosis detection in MASLD. A molecular gene expression signature identified from a diet-induced MASLD mouse model (LDLr-/-.Leiden) is translated into human blood-based biomarkers based on liver biopsy transcriptomic profiles and protein levels in MASLD patient serum samples...
May 29, 2024: Nature Communications
https://read.qxmd.com/read/38811325/unraveling-factors-associated-with-textbook-outcome-after-cholecystectomy-in-patients-with-uncomplicated-cholecystolithiasis-a-posthoc-analysis-of-individual-data-of-1-124-patients
#44
JOURNAL ARTICLE
Daan J Comes, Floris M Thunnissen, Carmen S S Latenstein, Martijn W J Stommel, Cornelis J H M van Laarhoven, Joost P H Drenth, Femke Atsma, Marten A Lantinga, Philip R de Reuver
BACKGROUND: A textbook outcome for the management of uncomplicated cholecystolithiasis is the targeted clinical scenario and is characterized by no recurrent biliary colic, absence of surgical and biliary complications, and absence or relief of abdominal pain. The aim of this study was to assess the incidence of textbook outcomes after cholecystectomy and identify associated baseline factors. METHODS: Patients from 2 Dutch multicenter prospective trials between 2014 and 2019 (SECURE and SUCCESS trial) were included...
May 29, 2024: Surgery
https://read.qxmd.com/read/38811200/the-chromosome-level-whole-genome-sequence-and-the-seconary-matabolism-gene-cluster-prediction-of-fusarium-meridionale-the-pathogen-causing-maize-ear-rot
#45
JOURNAL ARTICLE
Qing Du, Zhaolei Tang, Juegui Su, Shichu Li
Fusarium meridionale is one of the pathogens causing maize ear rot, it produce bioactive secondary metabolites may threaten humans food safty, however, the production mechanism of the secondary metabolites and their interaction with maize ear remains poorly understood. To facilitate related studies, we sequenced and assembled the genome of F. meridionale strain JX18-4. The size of F. meridionale JX18-4 genome is 37.11 Mbp, include four nuclear chromosome contigs that consists of 11920 coding genes and one mitochondrial contig...
May 28, 2024: Journal of General and Applied Microbiology
https://read.qxmd.com/read/38810981/combination-of-a-permanent-slow-flow-managed-by-the-nurse-and-a-rapid-flow-for-bleeding-management-controlled-by-the-doctor-in-underwater-endoscopic-submucosal-dissection
#46
JOURNAL ARTICLE
Auxane Chauveau, Soline Brun, Marina Cornelis, Muriel Deschamp, Laetitia Chevrot, Mikael Mochet, Mathieu Pioche
No abstract text is available yet for this article.
December 2024: Endoscopy
https://read.qxmd.com/read/38810800/rhizosphere-enrichment-and-crop-utilization-of-selenium-and-metals-in-typical-permian-soils-of-enshi
#47
JOURNAL ARTICLE
Chengfeng Jiang, Wei Zhou, Shuxin Tu, Jiali Yan, Liangzhe Yang
Enshi, China, is renowned as "Selenium(Se) Capital" where widely distributed soils derived from Permian parent rocks are notably rich in Se, as well as metals, particularly cadmium(Cd). However, the soil enrichment and crop uptake of Se and metals in these high-Se and high-Cd areas are not well understood. To propose the optimal crop planting plan to ensure the safety of agricultural products, we investigated the soils and corresponding typical crops (rice, tea, and maize). The results showed significant soil enrichment of elements, with average contents (mg/kg) as follows: Cr (185), Zn (126), Cu (58...
May 27, 2024: Chemosphere
https://read.qxmd.com/read/38810457/dual-modified-starch-micelles-as-nanocarriers-for-efficient-encapsulation-and-controlled-release-of-walnut-derived-active-peptides
#48
JOURNAL ARTICLE
Xuehang Wang, Yuan Qi, Weiyu Hou, Dan Wu, Li Fang, Yue Leng, Xiaoting Liu, Xiyan Wang, Ji Wang, Weihong Min
Hydrophilic and hydrophobic modified nanomicelles might be more conducive to passage of the gastrointestinal barrier than walnut peptide (WP). In this study, a novel double modified starch polymer, SB-CST-DCA, was synthesized by grafting sulfabetaine (SB) and deoxycholic acid (DCA) onto corn starch (CST) molecules through etherification and esterification. The modification mechanism was discussed to determine its chemical structure, morphological properties, and thermal stability. Peptide-loaded nanomicelles (SB-CST-DCA-WP) were prepared using WP as the core material...
May 23, 2024: Food Chemistry
https://read.qxmd.com/read/38810398/intraperitoneal-pharmacokinetics-of-systemic-oxaliplatin-5-fluorouracil-and-bevacizumab-in-patients-with-colorectal-peritoneal-metastases
#49
JOURNAL ARTICLE
Pascale C S Rietveld, Niels A D Guchelaar, Ruben A G van Eerden, Nadine L de Boer, Peter de Bruijn, Sebastiaan D T Sassen, Eva V E Madsen, Birgit C P Koch, Cornelis Verhoef, Jacobus W A Burger, Ron H J Mathijssen, Stijn L W Koolen
BACKGROUND: Peritoneal metastases (PM) commonly occur in colorectal cancer patients. Systemic chemotherapy yields poor outcomes for these patients. It is hypothesised that traditional systemic chemotherapy is not very effective for this patient population. This study investigates to what extent systemic anti-cancer therapy crosses the peritoneal barrier. METHODS: In a Phase I study, eighteen patients received systemic oxaliplatin, 5-FU, and bevacizumab. Plasma and peritoneal fluid samples were collected to measure drug concentrations...
May 28, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38809880/evolution-of-the-spatiotemporal-pattern-of-china-s-grain-production-in-the-past-20-years-and-its-driving-mechanism
#50
JOURNAL ARTICLE
Longbo Ma, Binyu Yang, Huijie Zhang, Wenbin Jiang, Liyu Ju
Food security is a goal and means of global sustainable development, and an important component of China's national security. Based on grain production data from 2000 to 2020, 31 provinces (cities, autonomous regions) in China were used as research units to analyze the spatiotemporal differences and driving forces of grain production in China using a combination of local correlation index, center of gravity transfer model, and geographic detector. The results as follows, ① During the research period, China's total grain production showed a decrease followed by an increase, and the yield per unit area of grain showed an increasing trend...
2024: PloS One
https://read.qxmd.com/read/38809796/-multi-strain-probiotic-combined-with-dietary-fiber-is-an-effective-factor-in-the-nutritional-support-of-immunity-in-athletes
#51
RANDOMIZED CONTROLLED TRIAL
E N Trushina, N A Riger, O K Mustafina, A N Timonin, T N Solntseva, I S Zilova, I V Kobelkova, D B Nikityuk
A priority in the prevention and correction of immune disorders in athletes is the use of products with high nutrient density, fortified with various nutrients or bioactive compounds, as well as probiotic microorganisms. Probiotics help to maintain the gut microbiota, which is actively involved in the absorption of substances and energy and increases the host immune resistance. Dietary fiber, resistant to digestion in the small intestine, is fully or partially fermented in the large intestine and acts as an essential substrate for the growth and regulation of metabolic activity of normal flora, improves peristalsis and digestion...
2024: Voprosy Pitaniia
https://read.qxmd.com/read/38809794/discovery-of-novel-n-phenyltriazinone-derivatives-containing-oxime-ether-or-oxime-ester-moieties-as-promising-protoporphyrinogen-ix-oxidase-inhibitors
#52
JOURNAL ARTICLE
Wei Zhang, Jiahui Zhang, Chaohui Yan, Xiuhai Gan
Protoporphyrinogen IX oxidase (PPO, EC 1.3.3.4) is one of the most important targets for the discovery of green herbicides. In order to find novel PPO inhibitors with a higher herbicidal activity, a series of novel N -phenyltriazinone derivatives containing oxime ether and oxime ester groups were designed and synthesized based on the strategy of pharmacophore and scaffold hopping. Bioassay results revealed that some compounds showed herbicidal activities; especially, compound B16 exhibited broad-spectrum and excellent 100% herbicidal effects to Echinochloa crusgalli , Digitaria sanguinalis , Setaria faberii , Abutilon juncea , Amaranthus retroflexus , and Portulaca oleracea at a concentration of 37...
May 29, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38809677/erratum-to-compensatory-movement-patterns-are-based-on-abnormal-activity-of-the-biceps-brachii-and-posterior-deltoid-muscles-in-patients-with-symptomatic-rotator-cuff-tears
#53
JOURNAL ARTICLE
Egbert J D Veen, Cornelis T Koorevaar, Koen H M Verdonschot, Tim E Sluijter, Tom M de Groot, Johannes H van der Hoeven, Ronald L Diercks, Martin Stevens
No abstract text is available yet for this article.
June 1, 2024: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/38809353/glass-bead-system-to-study-mycotoxin-production-of-aspergillus-spp-on-corn-and-rice-starches
#54
JOURNAL ARTICLE
Katalin Inotai, Ildikó Bata-Vidács, Ákos Tóth, Judit Kosztik, Mónika Varga, András Szekeres, István Nagy, István Nagy, Csaba Dobolyi, Mária Mörtl, András Székács, József Kukolya
Mycotoxin production by aflatoxin B1 (AFB1) -producing Aspergillus flavus Zt41 and sterigmatocystin (ST) -hyperproducer Aspergillus creber 2663 mold strains on corn and rice starch, both of high purity and nearly identical amylose-amylopectin composition, as the only source of carbon, was studied. Scanning electron microscopy revealed average starch particle sizes of 4.54 ± 0.635 µm and 10.9 ± 2.78 µm, corresponding to surface area to volume ratios of 127 1/µm for rice starch and 0...
May 29, 2024: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/38809276/genetic-mapping-of-loci-affecting-seedling-and-adult-plant-resistance-to-powdery-mildew-derived-from-two-cimmyt-wheat-lines
#55
JOURNAL ARTICLE
Hossein Golzar, Manisha Shankar, Beata Sznajder, Rebecca Fox, Karyn Reeves, Diane E Mather
PM3 and PM8 alleles carried by two CIMMYT wheat lines confer powdery mildew resistance in seedlings and/or adult plants. A stage-specific epistatic interaction was observed between PM3 and PM8. Powdery mildew is an important foliar disease of wheat. Major genes for resistance, which have been widely used in wheat breeding programs, are typically effective against only limited numbers of virulence genes of the pathogen. The main aim of this study was to map resistance loci in wheat lines 7HRWSN58 and ZWW09-149 from the International Maize and Wheat Improvement Center (CIMMYT)...
May 29, 2024: Planta
https://read.qxmd.com/read/38808784/determination-of-fumonisin-content-in-maize-using-near-infrared-hyperspectral-imaging-nir-hsi-technology-and-chemometric-methods
#56
JOURNAL ARTICLE
R R P Conceição, V A V Queiroz, E P Medeiros, J B Araújo, D D S Araújo, R A Miguel, M A R Stoianoff, M L F Simeone
Maize (Zea mays L.) is of socioeconomic importance as an essential food for human and animal nutrition. However, cereals are susceptible to attack by mycotoxin-producing fungi, which can damage health. The methods most commonly used to detect and quantify mycotoxins are expensive and time-consuming. Therefore, alternative non-destructive methods are required urgently. The present study aimed to use near-infrared spectroscopy with hyperspectral imaging (NIR-HSI) and multivariate image analysis to develop a rapid and accurate method for quantifying fumonisins in whole grains of six naturally contaminated maize cultivars...
2024: Brazilian Journal of Biology
https://read.qxmd.com/read/38808276/effects-of-different-restoration-stages-on-soil-microbial-community-composition-and-diversity-in-naolihe-wetland-china
#57
JOURNAL ARTICLE
Xiangzheng Meng, Manhong Liu, Zhaojun Meng, Chengdan Wu, Chonglin Bao, Bin Xu, Guangxin Wang, Huan Ma, Ze Liu, Xu Zheng, Xingyu Xie, Xingbo Cui
Soil microorganisms can be used as one of the important indicators of wetland ecosystem restoration. To study the effects of different restoration stages on soil microbial community composition and diversity in Naolihe Wetland, we employed a "time and space parallel" method. Four restoration stages, namely corn field (Corn), short-term restoration wetland (2 years, ST), long-term restoration wetland (8 years, LT) and natural wetland (>25 years, NW), were selected to represent the restoration time and geographical location in Naolihe Nature Wetland...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38807576/coercion-during-psychiatric-ambulance-versus-police-transport-in-mental-health-crises-a-pre-and-postimplementation-study
#58
JOURNAL ARTICLE
Jeroen B Zoeteman, Mathilde A S de Wit, Hans J de Haas, Kate M Borkent, Jaap Peen, Cornelis L Mulder, Jack Dekker
OBJECTIVE: Police officers are often the first responders when individuals experience a mental health crisis and typically remain responsible for transport to a psychiatric emergency department. In 2014, a psychiatric ambulance (PA) was introduced in the city of Amsterdam to take over the transport of individuals in a mental health crisis. The purpose of the PA was to use fewer restrictive measures while guaranteeing safety for both patients and personnel. METHODS: A preimplementation-postimplementation design was used to assess the feasibility and utility of a single-vehicle PA service compared with police transport...
May 29, 2024: Psychiatric Services: a Journal of the American Psychiatric Association
https://read.qxmd.com/read/38807300/clinical-phenotypes-of-adults-with-monogenic-and-syndromic-genetic-obesity
#59
JOURNAL ARTICLE
Mila S Welling, Mostafa Mohseni, Renate E H Meeusen, Cornelis J de Groot, Mariëtte R Boon, Lotte Kleinendorst, Jenny A Visser, Mieke M van Haelst, Erica L T van den Akker, Elisabeth F C van Rossum
OBJECTIVE: Considering limited evidence on diagnostics of genetic obesity in adults, we evaluated phenotypes of adults with genetic obesity. Additionally, we assessed the applicability of Endocrine Society (ES) recommendations for genetic testing in pediatric obesity. METHODS: We compared clinical features, including age of onset of obesity and appetite, between adults with non-syndromic monogenic obesity (MO), adults with syndromic obesity (SO), and adults with common obesity (CO) as control patients...
May 28, 2024: Obesity
https://read.qxmd.com/read/38806974/challenges-in-assessing-the-immunization-status-of-adults-in-germany-lessons-from-a-population-based-vaccelerate-survey-on-polio-vaccination
#60
JOURNAL ARTICLE
Julia A Nacov, Jannik Stemler, Jon Salmanton-García, Louise M Cremer, Markus Zeitlinger, Patrick W G Mallon, Zoi Dorothea Pana, Heinz-Josef Schmitt, Oliver A Cornely
PURPOSE: Considering the re-emergence of poliomyelitis (PM) in non-endemic regions, it becomes apparent that vaccine preventable diseases can rapidly develop epi- or even pandemic potential. Evaluation of the current vaccination status is required to inform patients, health care providers and policy makers about vaccination gaps. METHODS: Between October 28 2022 and November 23 2022, 5,989 adults from the VACCELEREATE Volunteer Registry completed an electronic case report form on their previous PM vaccine doses including number, types/-valencies and the time of administration based on their vaccination records...
May 28, 2024: Infection
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