Ye Zhou, Yuanqi Zhao, Marisa Carbonaro, Helen Chen, Mary Germino, Christina Adler, Min Ni, Yuan O Zhu, Sun Y Kim, Judith Altarejos, Zhe Li, Michael E Burczynski, David J Glass, Mark W Sleeman, Ann-Hwee Lee, Gabor Halasz, Xiping Cheng
Liver zonation characterizes the separation of metabolic pathways along the lobules and is required for optimal hepatic function. Wnt signaling is a master regulator of spatial liver zonation. A perivenous-periportal Wnt activity gradient orchestrates metabolic zonation by activating gene expression in perivenous hepatocytes, while suppressing gene expression in their periportal counterparts. However, the understanding as to the liver gene zonation and zonation regulators in diseases is limited. Non-alcoholic steatohepatitis (NASH) is a chronic liver disease characterized by fat accumulation, inflammation, and fibrosis...
February 28, 2024: Metabolism: Clinical and Experimental