Zhenxing Ren, Ling Zhao, Mingliang Zhao, Tianhao Bao, Tianlu Chen, Aihua Zhao, Xiaojiao Zheng, Xinru Gu, Tao Sun, Yuhuai Guo, Yajun Tang, Guoxiang Xie, Wei Jia
Cognitive impairment in the elderly is associated with alterations in bile acid (BA) metabolism. In this study, we observe elevated levels of serum conjugated primary bile acids (CPBAs) and ammonia in elderly individuals, mild cognitive impairment, Alzheimer's disease, and aging rodents, with a more pronounced change in females. These changes are correlated with increased expression of the ileal apical sodium-bile acid transporter (ASBT), hippocampal synapse loss, and elevated brain CPBA and ammonia levels in rodents...
April 24, 2024: Cell reports medicine