Adam M Passman, Magnus J Haughey, Emanuela Carlotti, Marc J Williams, Bianca Cereser, Meng-Lay Lin, Shruthi Devkumar, Jonathan P Gabriel, Enrico Gringeri, Umberto Cillo, Francesco Paolo Russo, Matthew Hoare, Joanne ChinAleong, Marnix Jansen, Nicholas A Wright, Hermant M Kocher, Weini Huang, Malcolm R Alison, Stuart A C McDonald
BACKGROUND & AIMS: While normal human liver is thought to be generally quiescent, clonal hepatocyte expansions have been observed, though neither their cellular source nor their expansion dynamics have been determined. Knowing the hepatocyte cell of origin, and their subsequent dynamics and trajectory within the human liver will provide an important basis to understand disease-associated dysregulation. METHODS: Herein, we use in vivo lineage tracing and methylation sequence analysis to demonstrate normal human hepatocyte ancestry...
August 2023: Journal of Hepatology