Yuman He, Linhong Jiang, Haxiaoyu Liu, Qian Bu, Weihong Kuang, Ying Zhao, Yaxing Chen, Ni Zhang, Yuzhou Xiao, Shu Li, Rong Chen, Shuang Han, Yuanyi Zhou, Jiamei Zhang, Xuemei Wan, Rui Xu, Shaomin Wang, Haoluo Zhang, Hui Gu, Qingfan Wei, Feng Qin, Yue Zhao, Hongchun Li, Liang Wang, Xiaojie Wang, Yonghai Wang, Yanping Dai, Min Li, Yuanyuan Chen, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Cen
BACKGROUND: Circular RNAs (circRNAs) are highly enriched in the synapses of the mammalian brain and play important roles in neurological function by acting as molecular sponges of microRNAs (miRNAs). CircAnk3 is derived from the 11th intron of the Ankyrin 3 (Ank3) gene, a strong genetic risk factor for neuropsychiatric disorders; however, the function of circAnk3 remains elusive. In this study, we investigated the function of circAnk3 and its downstream regulatory network for target genes in the hippocampus of mice...
October 30, 2023: Biological Psychiatry