Lara Melo Campos, Ari Sérgio de Oliveira Lemos, Priscila de Lima Paula, Vinícius Novaes da Rocha, Marcelo Gonzaga de Freitas Araújo, Guilherme Diniz Tavares, Thais Nogueira Barradas, Wesley William Gonçalves Nascimento, Angelo Mácio Leite Denadai, Luiz Fernando Cappa de Oliveira, Rodrigo Luiz Fabri
Vulvovaginal candidiasis, mostly caused by Candida albicans, remains a prevalent concern in women's health. Annona muricata L. (Annonaceae), a plant native from Brazil, is well-known for its therapeutic potential, including antitumor, anti-inflammatory, and antimicrobial properties. This study presents an innovative hydrogel formulation containing the ethanolic extract from A. muricata leaves designed to control C. albicans in an in vivo model of vulvovaginal candidiasis. Here, we report the development, thermal, physicochemical and rheological characterization of a Carbopol®-based hydrogel containing A...
April 15, 2024: Colloids and Surfaces. B, Biointerfaces