Panagiotis Korovessis, Evangelia Mpountogianni, Ioannis Papaioannou
PURPOSE: Loss of "physiological" sagittal alignment following craniocervical fusion (CCF) for degenerative disease may be associated with loss of horizontal gaze, dysphagia and poor HRQOL. This study reports on sagittal craniocervical roentgenographic predictors of HRQOL (SF-36) in patients following uncomplicated CCF for fresh upper cervical traumatic (UCT) injuries. METHODS: Twenty-two consecutive adult patients (group P) aged 50 ± 16 years, who had undergone CCF for fresh unstable C1 and C2 AO/type UCT injuries, were evaluated 39 ± 12 months postoperatively with upright lateral cervical roentgenograms and SF-36as HRQOL measure...
July 29, 2021: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Julia M Unglaub, Thomas Bruckner, Thomas J Heyse, Peer Eysel, Martin F Langer, Christian K Spies
PURPOSE: Goal of this study was the assessment of long-term outcome of arthroscopically assisted repair of Palmer 1B/Atzei 1 triangular fibrocartilage complex tears and the comparison with short- and mid-term results. METHODS: The study included nineteen patients (mean 49.2 years of age) with a mean follow-up time of 13.6 years (13.1-14.3 years). Examination parameters included disabilities of arm, shoulder, and hand (DASH) questionnaire, modified Mayo Wrist Score (MMWS), Krimmer Score, determination of range of motion in comparison to the contralateral extremity...
July 29, 2021: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
A Hafner, P-D Ghislain, R Kovács, R Batchelor, A C Katoulis, B Kirby, H Banayan, M Schonbrun
BACKGROUND: Hidradenitis suppurativa (HS), a chronic, recurrent, debilitating skin disease, is characterized by painful, inflammatory, subcutaneous lesions of the axilla, inguinal, and anogenital regions. Overall prevalence of HS is ~1%, and impact of disease on patient quality of life (QoL) and healthcare resource utilization (HRU) is high. OBJECTIVES: To estimate the real-world effectiveness of adalimumab (Humira® ) treatment in patients with moderate to severe HS on disease severity, pain, QoL, work productivity, and HRU...
July 28, 2021: Journal of the European Academy of Dermatology and Venereology: JEADV
Fabio Galbusera, Pierre Côtè, Stefano Negrini
PURPOSE: The COVID-19 pandemic and the containment measures such as social distancing, mobility restrictions and quarantine have significantly impacted the delivery of healthcare services, with possible negative effects on low back pain patients. In this study, we used an innovative agent-based model to quantify the effects of COVID-19 on the prevalence and severity of low back pain in the general population. METHODS: Epidemiological data were used to simulate the low back pain evolution in a population of 300,000 agents...
July 27, 2021: European Spine Journal
Eisuke Ochi, Hisashi Ueda, Yosuke Tsuchiya, Koichi Nakazato
PURPOSE: This study was aimed at investigating the effect of eccentric contractions (ECCs) of flexor pollicis brevis muscles (FPBMs) on motor and sensory nerve functions as well as the ipsilateral repeated bout effect (IL-RBE) and contralateral (CL)-RBE of motor and sensory nerve conduction velocities following ECCs. METHODS: Thirty-two young healthy men (age: 19.6 ± 0.2 years, height: 173.2 ± 1.2 cm, body mass: 69.7 ± 1.9 kg) performed two bouts of ECCs...
July 27, 2021: European Journal of Applied Physiology
M W Petersen, S Skovbjerg, J S Jensen, T Carstensen, T M Dantoft, P Fink, M E Benros, E L Mortensen, T Jørgensen, L K Gormsen
Disrupted pain regulation has been proposed as a component in functional somatic disorders (FSD). The objective of this study was to examine a general population sample, encompassing three delimitations of FSD while assessing pain sensitivity and conditioning pain modulation (CPM). Pressure pain thresholds (PPTs) at the tibialis and trapezius muscles were recorded at baseline. During cold pressor stimulation of the hand, the tibialis PPTs were re-assessed and the difference from baseline measures defined the CPM effect...
July 26, 2021: European Journal of Pain: EJP
Kathrin Zürcher, Carole Dupont, Peter Weber, Sebastian Grunt, Ilca Wilhelm, Daniela E Eigenmann, Martina L Reichmuth, Manfred Fankhauser, Matthias Egger, Lukas Fenner
Evidence on the use and efficacy of medical cannabis for children is limited. We examined clinical and epidemiological characteristics of medical cannabis treatment and caregiver-reported effects in children and adolescents in Switzerland. We collected clinical data from children and adolescents (< 18 years) who received Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), or a combination of the two between 2008 and 2019 in Switzerland. Out of 205 contacted families, 90 agreed to participate. The median age at the first prescription was 11...
July 26, 2021: European Journal of Pediatrics
Jose María Llamas-Molina, Alejandro Carrero Castaño, Ricardo Ruiz-Villaverde
No abstract text is available yet for this article.
June 1, 2021: European Journal of Dermatology: EJD
Bernd Erber, Andrea Baur-Melnyk, Christian Glaser, Sophia Goller, Jens Ricke, Andreas Heuck
PURPOSE: Edema of the quadriceps fat pad (QFP) in MR imaging has been described as a distinct finding associated with anterior knee pain, its etiology, however, remains under debate. The aim of this study was to investigate a potential relationship between QFP edema, alterations of the quadriceps tendon (QT) and other anterior knee structures. METHOD: 800 consecutive, clinically indicated MRI exams of the knee at 3T were retrospectively analyzed for the absence or presence of QFP edema...
July 13, 2021: European Journal of Radiology
Swarne E, M S Srikanth, Ayachit Shreyas, Sneha Desai, Seema Mehdi, H V Gangadharappa, Suman, K L Krishna
Cholelithiasis is a common and frequent condition all over the world with a high prevalence rate in western countries. Individuals with cholesterol gallstone disease experience intense gastrointestinal symptoms and have a high risk of developing comorbidities like cholecystitis, Gall bladder (GB) cancer and pancreatitis. Multiple risk factors associated with cholesterol gallstones include but not limited to genetics, dietary habits, lifestyle changes, comorbid conditions and various drugs. These factors may lead to alteration in bile, cholesterol & phospholipids homeostasis in the GB, intestine and hepatocytes culminating in cholesterol gallstones formation...
July 22, 2021: European Journal of Pharmacology
Sabrina A N Doelare, Dayanara M Jean Pierre, Johanna H Nederhoed, Stefan P M Smorenburg, Rutger J Lely, Vincent Jongkind, Arjan W J Hoksbergen, Harm P Ebben, Kak K Yeung
OBJECTIVE: Acute peripheral arterial occlusions can be treated by catheter directed thrombolysis (CDT). However, CDT is time consuming and accompanied by the risk of bleeding complications. The addition of contrast enhanced ultrasound and microbubbles could improve thrombus susceptibility to thrombolytic agents and potentially shorten treatment time with a lowered risk of bleeding complications. This article reports the outcomes of the safety and feasibility of this novel technique. METHODS: In this single arm phase II trial, 20 patients with acute lower limb ischaemia received CDT combined with an intravenous infusion of microbubbles and locally applied ultrasound during the first hour of standard intra-arterial thrombolytic therapy...
July 21, 2021: European Journal of Vascular and Endovascular Surgery
H Y Sun, D F Sebaratnam
A 19-year-old female of South Asian descent presented with a three-day history of pruritic, clustered papules and vesicles on her abdomen, associated with significant pruritus and intermittent pain. She commenced a ketogenic diet four days prior to the emergence of the rash. Histopathological and clinical findings were in keeping with prurigo pigmentosa, an uncommon dermatosis characterised by pruritic, erythematous papules and vesicles presenting reticulated on the back, chest and neck. Prurigo pigmentosa may be distinguished from many other skin lesions by its reticular pattern...
July 23, 2021: European Journal of Clinical Nutrition
Yulu Zhou, Yanhong Su, Zuojun Li, Cuifang Wu, Wei Sun, Chunjiang Wang
OBJECTIVES: Dabigatran-induced oesophagitis has emerged in recent years. However, the incidence and clinical characteristics of patients with dabigatran-induced oesophagitis have not yet been clarified. The aim of this study was to examine the clinical characteristics of the disease. METHODS: A retrospective analysis was undertaken of the literature on dabigatran-induced oesophagitis in Chinese and English from 2008 onwards. RESULTS: There were 20 men (74...
July 22, 2021: European Journal of Hospital Pharmacy. Science and Practice
Enrico Leo, Alessandro C L Molinari, Marco Ferraresi, Giovanni Rossi
OBJECTIVE: The aim of this study was to evaluate the peri-operative and short term results of institutional experience with the Distal Extended EndoVascular Aortic Repair PETTICOAT (DEEVAR PETTICOAT) procedure. METHODS: This was a single centre, observational study. From January 2015 to December 2019, 53 patients were admitted to the institution for treatment of acute and subacute complicated type B aortic dissection. Among them, data on 16 patients deemed suitable for a PETTICOAT procedure extended at infrarenal and iliac level by means of a bifurcated endograft were prospectively collected...
July 20, 2021: European Journal of Vascular and Endovascular Surgery
Müjdem Nur Azılı, Doğuş Güney, Can Ihsan Oztorun, Ahmet Ertürk, Elif Emel Erten, Sabri Demir, Ayşe Ertoy, Serhat Emeksiz, Aslınur Ozkaya Parlakay, Banu Acar Celikel, Emrah Senel
INTRODUCTION:  The aim of this study was to make the differential diagnosis between acute appendicitis and multisystem inflammatory syndrome in children (MIS-C) for patients presenting with the complaint of acute abdominal pain (AAP) and to identify the determining factors for the diagnosis of MIS-C. MATERIALS AND METHODS:  Eighty-one children presenting with AAP/suspected AAP were evaluated. Of these, 24 (29.6%) were included in the MIS-C group (MIS-C/g) and 57 were included in the suspected appendicitis group (S-A/g), which consisted of two subgroups: appendicitis group (A/g) and control observation group (CO/g)...
July 23, 2021: European Journal of Pediatric Surgery
Daniel Rydbeck, Dan Asplund, David Bock, Eva Haglind, Jennifer Park, Jacob Rosenberg, Sofie Walming, Eva Angenete
AIM: This study aimed to investigate if younger age at diagnosis of colorectal cancer was associated with a diagnostic delay. The secondary objective was to evaluate if symptomatology varied with age. METHOD: The study population consisted of the cohorts from two prospective multicentre studies conducted in Sweden and Denmark, the QoLiRECT and QoLiCOL studies. These studies investigated the quality of life in patients with colorectal cancer. Participants responded to the validated questionnaires used to extract information on patient's and doctor's delay as well as first presenting symptoms...
July 20, 2021: European Journal of Cancer
Elfriede Greimel, Eva Nagele, Anne Lanceley, Anne S Oberguggenberger, Andy Nordin, Karin Kuljanic, Juan I Arraras, Chie Wei-Chu, Pernille T Jensen, Krzysztof A Tomaszewski, Carien L Creutzberg, Razvan Galalae, Hilde Toelen, Kristin Zimmermann, Vesna Bjelic-Radisic, Anna Costantini, Thierry Almont, Samantha Serpentini, Ligita Paskeviciute Frøding, Ingvild Vistad, Claudia Schmalz
BACKGROUND: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group developed a questionnaire to assess sexual health in patients with cancer and cancer survivors. This study evaluates the psychometric properties of the questionnaire. METHODS: The 22-item EORTC sexual health questionnaire (EORTC QLQ-SH22) was administered with the EORTC QLQ-C30 to 444 patients with cancer. The hypothesised scale structure, reliability and validity were evaluated through standardised psychometric procedures...
July 20, 2021: European Journal of Cancer
Malte Bogdahn, Johanna Torner, Julius Krause, Michael Grimm, Werner Weitschies
3D printing can be used to realise a wide variety of geometries of oral dosage forms. In this work, the swallowability of 3D-printed dosage forms with comparable size and different shape using fused deposition modelling (FDM) from isomalt was investigated in a controlled, randomised crossover study design. To produce the required number of dosage forms, a commercial 3D printer was modified with regard to product safety and production time. The modifications carried out permit the printing of 4 pharmaceutical forms simultaneously as well as the printing of rigid filaments...
July 20, 2021: European Journal of Pharmaceutics and Biopharmaceutics
Ben Baumberg Geiger
While disability benefits make up the largest group of claimants in high-income countries, we know surprisingly little about which disabled people are seen as 'deserving' benefits, nor whether different people in different countries judge deservingness-related characteristics similarly. This is surprising given they are increasingly the focus of retrenchment, which often affirms the deservingness of 'truly deserving' disabled people while focusing cuts and demands on those 'less deserving'. This article addresses this gap using two vignette-based factorial survey experiments: (i) the nine-country 'Stigma in Global Context - Mental Health Study' (SGC-MHS); (ii) a new YouGov survey in Norway/the UK, together with UK replication...
July 2021: Journal of European Social Policy
Simone Lena Stamm, Elisabeth Spichiger, Thomas Pabst, Stefanie Bachnick, Marie-Madlen Jeitziner
PURPOSE: The aims of this study are to assess symptoms, health-related quality of life (HRQoL) and associations between symptoms and HRQoL in adult patients with myeloma or lymphoma undergoing autologous stem-cell transplantation (ASCT) during the pre- and post-transplantation phases in the outpatient setting. METHODS: This longitudinal, observational study conducted at a Swiss tertiary care hospital assesses the prevalence, frequency, severity and distress of symptoms, as well as HRQoL prior to hospital admission (T1), within two weeks after hospital discharge (T2) and three months after hospital discharge (T3)...
June 25, 2021: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
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