Robert Wiesheu, Sarah C Edwards, Ann Hedley, Holly Hall, Marie Tosolini, Marcelo Gregorio Filho Fares da Silva, Nital Sumaria, Suzanne M Castenmiller, Leyma Wardak, Yasmin Optaczy, Amy Lynn, David G Hill, Alan J Hayes, Jodie Hay, Anna Kilbey, Robin Shaw, Declan Whyte, Peter J Walsh, Alison M Michie, Gerard J Graham, Anand Manoharan, Christina Halsey, Karen Blyth, Monika C Wolkers, Crispin Miller, Daniel J Pennington, Gareth W Jones, Jean-Jacques Fournie, Vasileios Bekiaris, Seth B Coffelt
In mice, γδ-T lymphocytes that express the co-stimulatory molecule, CD27, are committed to the IFNγ-producing lineage during thymic development. In the periphery, these cells play a critical role in host defense and anti-tumor immunity. Unlike αβ-T cells that rely on MHC-presented peptides to drive their terminal differentiation, it is unclear whether MHC-unrestricted γδ-T cells undergo further functional maturation after exiting the thymus. Here, we provide evidence of phenotypic and functional diversity within peripheral IFNγ-producing γδ T cells...
May 30, 2024: EMBO Journal