Anthipa Chokesuwattanaskul, Harmony Jiang, Rebecca L Bond, Daniel A Jimenez, Lucy L Russell, Harri Sivasathiaseelan, Jeremy C S Johnson, Elia Benhamou, Jennifer L Agustus, Janneke E P van Leeuwen, Peerapat Chokesuwattanaskul, Chris J D Hardy, Charles R Marshall, Jonathan D Rohrer, Jason D Warren
Abnormal reward processing is a hallmark of neurodegenerative diseases, most strikingly in frontotemporal dementia. However, the phenotypic repertoire and neuroanatomical substrates of abnormal reward behaviour in these diseases remain incompletely characterized and poorly understood. Here we addressed these issues in a large, intensively phenotyped patient cohort representing all major syndromes of sporadic frontotemporal dementia and Alzheimer's disease. We studied 27 patients with behavioural variant frontotemporal dementia, 58 with primary progressive aphasia (22 semantic variant, 24 non-fluent/agrammatic variant and 12 logopenic) and 34 with typical amnestic Alzheimer's disease, in relation to 42 healthy older individuals...
2023: Brain communications