Thijs W van Harten, Anne Heijmans, Sanneke van Rooden, Marieke J H Wermer, Matthias J P van Osch, Hugo J Kuijf, Susanne J van Veluw, Steven M Greenberg, Mark A van Buchem, Jeroen van der Grond, Marianne A A van Walderveen
BACKGROUND: Deep medullary vein (DMV) changes occur in cerebral small vessel diseases (SVD) and in Alzheimer's disease. Cerebral amyloid angiopathy (CAA) is a common SVD that has a high co-morbidity with Alzheimer's disease. So far, DMVs have not been evaluated in CAA. OBJECTIVE: To evaluate DMVs in Dutch-type hereditary CAA (D-CAA) mutation carriers and controls, in relation to MRI markers associated with D-CAA. METHODS: Quantitative DMV parameters length, tortuosity, inhomogeneity, and density were quantified on 7 Tesla 3D susceptibility weighted MRI in pre-symptomatic D-CAA mutation carriers (n = 8), symptomatic D-CAA mutation carriers (n = 8), and controls (n = 25)...
2022: Journal of Alzheimer's Disease: JAD