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JOURNAL ARTICLE
Sofie Rohde, Eugen Sandica, Kevin Veen, Oliver Miera, Antonio Amodeo, Carlo Pace Napoleone, Mustafa Özbaran, Joanna Sliwka, Timothy Thiruchelvam, Daniel Zimpfer, Stephan Schubert, Ad J J C Bogers, Theo M M H de By
OBJECTIVES: Ventricular assist device support as a bridge to transplant or recovery is a well-established therapy in children on the cardiac transplant waiting list. The goal of this study was to investigate the incidence of and the associated factors for cerebrovascular accidents in paediatric patients supported by a Berlin Heart EXCOR. METHODS: All patients <19 years of age supported by a Berlin Heart EXCOR between January 2011 and January 2021 from the European Registry for Patients with Mechanical Circulatory Support were included...
August 3, 2022: European Journal of Cardio-thoracic Surgery
#22
JOURNAL ARTICLE
Moyu Hasegawa, Yuji Tominaga, Takuji Watanabe, Takayoshi Ueno, Masaki Taira, Shigeru Miyagawa
A 2-year-old girl underwent the Fontan operation for aortic valve stenosis, mitral valve stenosis, a hypo-plastic left ventricle, and a non-compacted right ventricle. The patient's cardiac function reduced gradually thereafter, mainly due to systemic ventricular dysfunction. A Berlin Heart EXCOR (BHE) ventricular assist device with a 10-mL pump was implanted at 4 years of age. After 465 days, BHE support without major complications, the patient underwent heart transplantation. A safe and long-term BHE support was achieved with proper case selection and repeated examinations...
June 28, 2022: General Thoracic and Cardiovascular Surgery
#23
JOURNAL ARTICLE
Jamila Kremer, Abbas El-Dor, Wiebke Sommer, Ursula Tochtermann, Gregor Warnecke, Matthias Karck, Arjang Ruhparwar, Anna Lassia Meyer
OBJECTIVES: Our study objective was to analyse adverse events in adolescent and adult Berlin Heart EXCOR patients and to assess outcome of subsequent heart transplantation (HTX). METHODS: From 2006 to 2020, 58 patients (12-64 years) received a biventricular assist device (BIVAD) at our institution and were included in this study. RESULTS: Causes of biventricular heart failure were non-ischaemic cardiomyopathy (62.1%), ischaemic cardiomyopathy (22...
May 9, 2022: Interactive Cardiovascular and Thoracic Surgery
#24
JOURNAL ARTICLE
Kriti Puri, Susan W Denfield, Iki Adachi, William J Dreyer, Jack F Price, Joseph A Spinner, Swati Choudhry, Julienne Brackett, Gina Santucci, Nino C Rainusso, Hari P Tunuguntla
BACKGROUND: Guidance and data on ventricular assist device (VAD) support for children with chemotherapy-induced cardiomyopathy, particularly within the first 2 years after chemotherapy, are limited. METHODS: We performed a single-center retrospective case series, reviewing medical records of children <18 years of age with chemotherapy-induced cardiomyopathy and advanced heart failure (HF) who received durable VAD support. RESULTS: Six patients met inclusion criteria-5 HeartWare™ HVAD, 1 Berlin Heart EXCOR® ...
April 26, 2022: Pediatric Transplantation
#25
JOURNAL ARTICLE
Defne A Magnetta, Allison Reichhold, Philip T Thrush, Michael Monge, Gregory Webster, Anna Joong
Histiocytoid cardiomyopathy (HICMP) is a rare mitochondrial cardiomyopathy associated with recurrent life-threatening arrhythmias and variable degrees of systolic dysfunction. Successful heart transplantation for HICMP has been described, but there has been no published experience with biventricular assist device (BiVAD) support for intractable arrhythmias in HICMP. We report a 13 month old girl with left ventricular noncompaction and preserved systolic function who presented in cardiogenic shock secondary to incessant ventricular arrhythmias...
April 15, 2022: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#26
JOURNAL ARTICLE
Diana Milagros Torpoco Rivera, Jordan Schneider, David Lawrence, John Dentel, Swati Sehgal
Berlin Heart EXCOR ventricular assist device (VAD) implantation in children is widely used as bridge-to-heart transplantation. Berlin left ventricular assist device (LVAD) support as a bridge to recovery is rare. There is a scarcity of literature describing systematic evaluation in pediatric VAD explantation. Patient 1. A 3 month old boy presented with acute heart failure secondary to myocarditis. An echocardiogram demonstrated severely depressed left ventricular function. He required ECMO cannulation and was decannulated 11 days later...
February 1, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#27
JOURNAL ARTICLE
Sebastian Michel, Stefan Buchholz, Joscha Buech, Tobias Veit, Thomas Fabry, Jan Abicht, Nikolaus Thierfelder, Christoph Mueller, Laura Lily Rosenthal, Jelena Pabst von Ohain, Nikolaus Haas, Jürgen Hörer, Christian Hagl
OBJECTIVES: We evaluated the outcome of patients in cardiogenic shock receiving a paracorporeal pulsatile biventricular assist device as a bridge to transplantation. METHODS: We performed a retrospective single-centre analysis of all patients who received a Berlin Heart Excor® at our institution between 2004 and 2019. RESULTS: A total of 97 patients (90 adults, 7 paediatric) were analysed. Eighty-four patients were in Interagency Registry for Mechanically Assisted Circulatory Support level 1 (80 adults, 4 paediatric)...
March 24, 2022: European Journal of Cardio-thoracic Surgery
#28
JOURNAL ARTICLE
Victoria Yuan, Aekaansh Verma, Nicole K Schiavone, David N Rosenthal, Alison L Marsden
PURPOSE: The Berlin Heart EXCOR (BH) is the only FDA-approved, extracorporeal pulsatile ventricular assist device (VAD) for infants and children with heart failure. Clinicians control four settings on the device-systolic and diastolic drive pressures, device pump rate, and systolic time as a percentage of the pump cycle. However, interactions between BH pneumatics and the native circulation remain poorly understood. Thus, establishing appropriate device size and settings can be challenging on a patient-to-patient basis...
January 7, 2022: Cardiovascular Engineering and Technology
#29
REVIEW
Mikiko Ishido
It has been about 10 years since the revised Japanese Organ Transplant Law came into action. Organ donation from brain dead donors has increased in the past decade, but the number of recipients waiting for transplant is increasing more rapidly. Implantable continuous flow ventricular assist device, such as Jarvik 2000 and HeartWare, available from 2011, and Berlin heart EXCOR, available from 2015, has changed the scene for children with severe heart failure. About 80% of the patients who received heart transplantation (HTx) were supported by one of these devices, and average waiting time is 688±502 days...
August 2022: Journal of Cardiology
#30
JOURNAL ARTICLE
Matteo Ponzoni, Anna C Frigo, Biagio Castaldi, Alessia Cerutti, Giovanni Di Salvo, Vladimiro L Vida, Massimo A Padalino
End-stage heart failure (ESHF) in pediatric age is an ongoing challenge. Heart transplantation is the final option, but its long-term outcomes are still suboptimal in children. An alternative patient-tailored surgical protocol to manage ESHF in children is described. Retrospective, single-center analysis of pediatric patients admitted to our institution between April 2004 and February 2021 for ESHF. Our current protocol is as follows: (a) Patients <1 year with isolated left ventricular dysfunction due to dilated cardiomyopathy underwent pulmonary artery banding (PAB)...
December 2021: Artificial Organs
#31
JOURNAL ARTICLE
Daniel Wilkinson, Yihan Lin, Melanie Everett, Scott Auerbach, Gareth Morgan, Max B Mitchell
We describe a successful bridge to recovery by coronary reimplantation and Berlin Heart EXCOR left ventricular assist device in a child with left main coronary artery ostial atresia and severe ischemic cardiomyopathy.
July 15, 2021: World Journal for Pediatric & Congenital Heart Surgery
#32
JOURNAL ARTICLE
Pia Lanmueller, Jaime-Juergen Eulert-Grehn, Felix Schoenrath, Burkert Pieske, Johanna Mulzer, Marcus Mueller, Volkmar Falk, Evgenij Potapov
Only few patients with heart failure with preserved ejection fraction undergo durable mechanical circulatory support implantation. We identified three patients with heart failure with preserved ejection fraction who needed durable mechanical circulatory support as bridge-to-transplant therapy. In two patients with hypertrophic cardiomyopathy, the hypertrophic papillary muscles and myocardium were resected to allow for subsequent left ventricular assist device implantation. In one patient, all visible parts of the mitral valve were additionally resected...
October 4, 2021: Interactive Cardiovascular and Thoracic Surgery
#33
JOURNAL ARTICLE
Birgitta Romlin, Anna Dahlin, Stefan Hallhagen, Kerstin Björk, Håkan Wåhlander, Fredrik Söderlund
BACKGROUND: Heart failure is a rare condition in the paediatric population, associated with high morbidity and mortality. When medical therapy is no longer sufficient, mechanical circulatory support such as a ventricular assist device can be used to bridge these children to transplant or recovery. Coagulation-related complications such as thrombi, embolism and bleeding events represent the greatest challenge in paediatric patients on mechanical support. We aimed to describe the outcomes and coagulation-related complications in this patient population at our institution...
July 2021: Acta Anaesthesiologica Scandinavica
#34
JOURNAL ARTICLE
Farhan Zafar, Jennifer Conway, Mark S Bleiweis, Mohammed Al-Aklabi, Rebecca Ameduri, Aliessa Barnes, David W Bearl, Holger Buchholz, Stephanie Church, Nhue L Do, Vicky Duffy, John C Dykes, Pirooz Eghtesady, Lauren Fisher, Joshua Friedland-Little, Stephanie Fuller, Francis Fynn-Thompson, Kristen George, Jeffrey G Gossett, Eric R Griffiths, Massimo Griselli, Beth Hawkins, Osami Honjo, Aamir Jeewa, Anna Joong, Steven Kindel, Peter Kouretas, Angela Lorts, Desiree Machado, Katsuhide Maeda, Andrea Maurich, Lindsay J May, Patrick McConnell, Mary Mehegan, Michael Mongé, David L S Morales, Jenna Murray, Robert A Niebler, Matthew O'Connor, David M Peng, Christina Phelps, Joseph Philip, Michelle Ploutz, Michael Profsky, Allison Reichhold, David N Rosenthal, Ahmed S Said, Kurt R Schumacher, Ming-Sing Si, Kathleen E Simpson, Joshua Sparks, Jim St Louis, Marie E Steiner, Christina VanderPluym, Chet Villa
BACKGROUND: The Berlin Heart EXCOR Pediatric (EXCOR) ventricular assist device (VAD) was introduced in North America nearly 2 decades ago. The EXCOR was approved under Humanitarian Device Exemption status in 2011 and received post-market approval (PMA) in 2017 from Food and Drug Administration. Since the initial approval, the field of pediatric mechanical circulatory support has changed, specifically with regard to available devices, anticoagulation strategies, and the types of patients supported...
April 2021: Journal of Heart and Lung Transplantation
#35
JOURNAL ARTICLE
Joseph Philip, Emma Powers, Desiree Machado, Dalia Lopez Colon, Dipankar Gupta, Renata Shih, Mohammad Ebraheem, Curt Fudge, Mark Bleiweis
BACKGROUND: The use of ventricular assist devices (VADs) as a bridge-to-transplant in patients with single-ventricle physiology post-stage one palliation has been associated with poor outcomes. We describe our center's successful experience in the use of paracorporeal pulsatile VADs in the palliation of high-risk single ventricle physiology before or after the first stage of palliation with an impetus on pre-palliation implant. METHODS: This is a single-center retrospective review of univentricular patients implanted with the Berlin Heart EXCOR VAD...
October 6, 2020: Journal of Thoracic and Cardiovascular Surgery
#36
JOURNAL ARTICLE
Jorge Martínez-Solano, Carlos Ortiz-Bautista, Eduardo Zatarain-Nicolás, Iago Sousa-Casasnovas, Álvaro Pedraz-Prieto, José M Barrio-Gutiérrez, Cristina Pascual-Izquierdo, Francisco Fernández-Avilés
Despite improvements in device design and hemocompatibility, intracranial hemorrhage and stroke remain the most feared and devastating complications in patients under mechanical circulatory support. We present the case of a 48 year old man with advanced heart failure (INTERMACS 3) and severe biventricular dysfunction who underwent biventricular pulsatile paracorporeal device implantation (Berlin Heart Excor) as a bridge to candidacy. Although on the heart transplantation waiting list, the patient experienced an intracranial hemorrhage, which was successfully managed by switching to a less thrombogenic biventricular assist device (Levitronix Centrimag) using the Excor cannulae, thus enabling temporary withdrawal of antithrombotic therapy...
October 1, 2021: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#37
EDITORIAL
Matteo Trezzi, Gianluca Brancaccio, Chiara Giorni, Zaccaria Ricci, Roberta Iacobelli, Luca di Chiara, Antonio Amodeo
En bloc heart-lung transplantation still represents definitive therapy for end-stage cardiopulmonary failure. However, patients may critically decompensate while awaiting suitable donor organs and necessitate veno-arterial extracorporeal membrane oxygenation. In this article, we describe the combined use of central cannulation with the Berlin Heart EXCOR ventricular assist device cannulae and the CentriMag centrifugal pump as an extended bridge to heart-lung transplantation in three pediatric patients.
March 2021: Journal of Cardiac Surgery
#38
Meike Schwendt, Johannes Kroll, Thilo Fleck, Brigitte Stiller
We report the case of a 3-month-old girl presenting with end-stage dilated cardiomyopathy and therapy-resistant cardiogenic shock. A left ventricular assist device (LVAD) Berlin Heart EXCOR was implanted, her organs recovered, and she was listed for heart transplantation. Two months later, while still on the LVAD, she was diagnosed with the rare genetic Alström syndrome. Weaning was no option, and she underwent successful heart transplantation at the age of 9 months. The follow-up 15 months later revealed an uneventful transplant course in a child with Alström syndrome...
January 2021: Thoracic and Cardiovascular Surgeon Reports
#39
JOURNAL ARTICLE
Joseph A Spinner, Hari P Tunuguntla, Sebastian C Tume, Barbara A Elias, Jason Mcmullen, Rija John, Swati Choudhry, Jack F Price, Susan W Denfield, William J Dreyer, Iki Adachi
The Jarvik 2015 Ventricular Assist Device (VAD) (Jarvik Inc, New York, NY) is the first and currently only continuous-flow VAD specifically designed for small children, and it is being evaluated in the so-called Pump for Kids, Infants, and Neonates (PumpKIN) trial. Due to the strict inclusion criteria of the trial, there have been a group of patients who failed to meet the criteria and therefore received the Jarvik 2015 VAD under the designation of "compassionate use." This is the same phenomenon seen previously during the Berlin Heart EXCOR trial...
January 11, 2021: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
#40
JOURNAL ARTICLE
Gamal M Marey, Sameh M Said, Rebecca Ameduri, Marie E Steiner, Michael Bowler, Ashley Loomis, Subin Jang, Massimo Griselli
Ventricular assist device (VAD) management continues to be a challenge in the presence of restrictive physiology. Left atrial (LA) decompression is not satisfactory even with good function and position of the left ventricular cannula. We describe an alternate approach with LA cannulation via the left atrial appendage (LAA) as a rescue strategy in a patient who had restrictive physiology, in our case was secondary to viral myocarditis acute systolic heart failure with subsequent insidious diffuse endomyocardial fibrosis and superimposed massive calcification, causing inadequate emptying of the left ventricle despite optimal VAD apical cannula position...
September 1, 2021: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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