Aurore C Poirier, Ruben D Riaño Moreno, Leona Takaindisa, Jessie Carpenter, Jai W Mehat, Abi Haddon, Mohammed A Rohaim, Craig Williams, Peter Burkhart, Chris Conlon, Matthew Wilson, Matthew McClumpha, Anna Stedman, Guido Cordoni, Manoharanehru Branavan, Mukunthan Tharmakulasingam, Nouman S Chaudhry, Nicolas Locker, Anil Fernando, Wamadeva Balachandran, Mark Bullen, Nadine Collins, David Rimer, Daniel L Horton, Muhammad Munir, Roberto M La Ragione
Introduction: Accurate and rapid diagnostics paired with effective tracking and tracing systems are key to halting the spread of infectious diseases, limiting the emergence of new variants and to monitor vaccine efficacy. The current gold standard test (RT-qPCR) for COVID-19 is highly accurate and sensitive, but is time-consuming, and requires expensive specialised, lab-based equipment. Methods: Herein, we report on the development of a SARS-CoV-2 (COVID-19) rapid and inexpensive diagnostic platform that relies on a reverse-transcription loop-mediated isothermal amplification (RT-LAMP) assay and a portable smart diagnostic device...
2023: Frontiers in Molecular Biosciences