Guanqun Ren, Yime Zhang, Jiamin Liu, Wenwen Cheng, Di Wu, Mengwei Han, Yanyu Zeng, Xingyu Zhao, Luni Hu, Min Zeng, Rama Krishna Gurram, Xiaole Hu, Bo Zhou, Zhiyuan Hou, Jinfang Zhu, Wenfei Jin, Chao Zhong
In mice, skin-resident type 2 innate lymphoid cells (ILC2s) exhibit some ILC3-like characteristics. However, the underlying mechanism remains elusive. Here, we observed lower expression of the ILC2 master regulator GATA3 specifically in cutaneous ILC2s (cILC2s) compared with canonical ILC2s, in line with its functionally divergent role in transcriptional control in cILC2s. Decreased levels of GATA3 enabled the expansion of RORγt fate-mapped (RORγtfm+ ) cILC2s after postnatal days, displaying certain similarities to ILC3s...
May 5, 2024: Developmental Cell