Alejandra Zazueta, Lucía Valenzuela-Pérez, Nicolás Ortiz-López, Araceli Pinto-León, Verónica Torres, Danette Guiñez, Nicolás Aliaga, Pablo Merino, Alexandra Sandoval, Natalia Covarrubias, Edith Pérez de Arce, Máximo Cattaneo, Alvaro Urzúa, Juan Pablo Roblero, Jaime Poniachik, Martín Gotteland, Fabien Magne, Caroll Jenny Beltrán
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex disorder whose prevalence is rapidly growing in South America. The disturbances in the microbiota-gut-liver axis impact the liver damaging processes toward fibrosis. Gut microbiota status is shaped by dietary and lifestyle factors, depending on geographic location. We aimed to identify microbial signatures in a group of Chilean MASLD patients. Forty subjects were recruited, including healthy controls (HCs), overweight/obese subjects (Ow/Ob), patients with MASLD without fibrosis (MASLD/F-), and MASLD with fibrosis (MASLD/F+)...
April 16, 2024: International Journal of Molecular Sciences