Yoshiaki Zaizen, Masaki Okamoto, Koichi Azuma, Junya Fukuoka, Hironao Hozumi, Noriho Sakamoto, Takafumi Suda, Hiroshi Mukae, Tomoaki Hoshino
BACKGROUND: Interstitial lung disease is frequently comorbid with dermatomyositis and has a poor prognosis, especially in patients with the anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody. However, the pathogenesis of dermatomyositis-related interstitial lung disease remains unclear. METHODS: We examined 18 and 19 patients with dermatomyositis-related interstitial lung disease and idiopathic pulmonary fibrosis (control), respectively. Lung tissues obtained from these patients were semi-quantitatively evaluated by immunohistochemical staining with in-house anti-human MDA5 monoclonal antibodies, as well as anti-human immunoglobulin (Ig) G, IgM, IgA, and complement component 3(C3) antibodies...
March 19, 2023: Respiratory Research
Andre Mu, William P Klare, Sarah L Baines, C N Ignatius Pang, Romain Guérillot, Nichaela Harbison-Price, Nadia Keller, Jonathan Wilksch, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Bernhard Keller, Brunda Nijagal, Dedreia Tull, Saravanan Dayalan, Hwa Huat Charlie Chua, Dominik Skoneczny, Jason Koval, Abderrahman Hachani, Anup D Shah, Nitika Neha, Snehal Jadhav, Sally R Partridge, Amanda J Cork, Kate Peters, Olivia Bertolla, Stephan Brouwer, Steven J Hancock, Laura Álvarez-Fraga, David M P De Oliveira, Brian Forde, Ashleigh Dale, Warasinee Mujchariyakul, Calum J Walsh, Ian Monk, Anna Fitzgerald, Mabel Lum, Carolina Correa-Ospina, Piklu Roy Chowdhury, Robert G Parton, James De Voss, James Beckett, Francois Monty, Jessica McKinnon, Xiaomin Song, John R Stephen, Marie Everest, Matt I Bellgard, Matthew Tinning, Michael Leeming, Dianna Hocking, Leila Jebeli, Nancy Wang, Nouri Ben Zakour, Serhat A Yasar, Stefano Vecchiarelli, Tonia Russell, Thiri Zaw, Tyrone Chen, Don Teng, Zena Kassir, Trevor Lithgow, Adam Jenney, Jason N Cole, Victor Nizet, Tania C Sorrell, Anton Y Peleg, David L Paterson, Scott A Beatson, Jemma Wu, Mark P Molloy, Anna E Syme, Robert J A Goode, Adam A Hunter, Grahame Bowland, Nicholas P West, Marc R Wilkins, Steven P Djordjevic, Mark R Davies, Torsten Seemann, Benjamin P Howden, Dana Pascovici, Sonika Tyagi, Ralf B Schittenhelm, David P De Souza, Malcolm J McConville, Jonathan R Iredell, Stuart J Cordwell, Richard A Strugnell, Timothy P Stinear, Mark A Schembri, Mark J Walker
Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enabling the identification of common bacterial targets for therapeutic intervention, we applied a standardized genomic, transcriptomic, proteomic and metabolomic technological framework to multiple clinical isolates of four sepsis-causing pathogens: Escherichia coli, Klebsiella pneumoniae species complex, Staphylococcus aureus and Streptococcus pyogenes...
March 18, 2023: Nature Communications
E Barja-Martínez, S García-González, E Jiménez-García, I J Thuissard-Vasallo, S Arias-Rivera, S Blanco-Abril
OBJECTIVE: To identify adverse events related to prone positioning in COVID-19 patients with severe disease and acute respiratory distress syndrome, to analyze the risk factors associated with the development of anterior pressure ulcers, to determine whether the recommendation of prone positioning is associated with improved clinical outcomes. METHODS: Retrospective study performed in 63 consecutive patients with COVID-19 pneumonia admitted to intensive care unit on invasive mechanical ventilation and treated with prone positioning between March and April 2020...
March 16, 2023: Enfermería intensiva
Lauro Vieira Perdigão Neto, Anna Silva Machado, Riberto Garcia da Silva, Ricardo Barbosa Cintra de Souza, Saurus Mayer Coutinho, Florencia Comello, Ana Paula Matos Porto, Daíla Sousa Lima, Thais Sabato Romano di Gioia, Victor Augusto Camarinha Castro Lima, Luis Arthur Brasil Gadelha Farias, Mariana Rolim Fernandes Macedo, Saidy Liceth Vasconez Noguera, Sandra Nascimento Dos Anjos, Chayenne Mika Matsumoto Pinto Tonheiro, Brunno César Batista Cocentino, Silvia Figueiredo Costa, Maura Salaroli de Oliveira
Effective therapies for multidrug-resistant (MDR) microorganisms, especially Gram-negative bacteria, are becoming rare. Also, solid-organ transplant recipients are at high risk of MDR Gram-negative bacilli infection. Urinary tract infections are the most frequent bacterial infections in kidney transplant recipients and are an important cause of mortality after renal transplantation. We describe a case of complicated urinary tract infection in a kidney transplant patient due to extensively drug-resistant (XDR) K...
March 16, 2023: Transplantation Proceedings
Federica Quarata, Diana Lelli, Davide Maria Biancone, Giovanni Gherardi, Raffaele Antonelli Incalzi
No abstract text is available yet for this article.
March 18, 2023: Lancet
Yu-Ying Yan, Yi Jin, Xiang-Yuan Cao, Song-Yu Chen, Wen-Hao Liu, Chen-Rui Shen, Yu-Shuang Qiu, Fu-Ming Shen, Min Ni
The present report firstly described a critically ill patient receiving a dosing regimen of ceftazidime-avibactam (CAZ-AVI) (1.875g q24h) to eliminate multidrug-resistant Klebsiella pneumoniae and a scheduled time for prolonged intermittent renal replacement therapy (PIRRT) every 48h (6h-session beginning 12h after the previous dosage on hemodialysis day). This dosing regimen for CAZ-AVI and a scheduled time for PIRRT allowed pharmacodynamic parameters of ceftazidime and avibactam to have little difference on hemodialysis and non-hemodialysis days so that we can maintain a relatively stable drug concentration...
March 16, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Ismail Hossain, Rokshana Parvin, Mohammad Mijanur Rahman, Jahan Ara Begum, Emdadul Haque Chowdhury, Mohammad Rafiqul Islam, Diego G Diel, Mohammed Nooruzzaman
Here, we performed molecular and pathogenic characterization of a Newcastle disease virus (NDV) isolate from pigeons in Bangladesh. Molecular phylogenetic analysis based on the complete fusion gene sequences classified the three study isolates into genotype XXI (sub-genotype XXI.1.2) together with recent NDV isolates obtained from pigeons in Pakistan (2014-2018). The Bayesian Markov Chain Monte Carlo analysis revealed that the ancestor of Bangladeshi pigeon NDVs and the viruses from sub-genotype XXI.1.2 existed in the late 1990s...
March 16, 2023: Microbial Pathogenesis
Zheng Pang, Tong-Jun Lin
Pseudomonas aeruginosa represents one of the major opportunistic pathogens, which causes nosocomial infections in immunocompromised individuals. The molecular mechanisms controlling the host immune response to P. aeruginosa infections are not completely understood. In our previous study, early growth response 1 (Egr-1) and regulator of calcineurin 1 (RCAN1) were found to positively and negatively regulate the inflammatory responses, respectively, during P. aeruginosa pulmonary infection, and both of them had an impact on activating NF-κB pathway...
March 15, 2023: Immunobiology
Domiziana Rinaldi, Gabriele Imbalzano, Silvia Galli, Edoardo Bianchini, Claudia Ledda, Lanfranco De Carolis, Maurizio Zibetti, Leonardo Lopiano, Francesco Ernesto Pontieri, Carlo Alberto Artusi
BACKGROUND: Dysphagia is common in advanced phases of Parkinson disease (PD), and is a risk factor for aspiration pneumonia. Nonetheless, dysphagia has been poorly investigated in PD patients treated with levodopa-carbidopa intestinal gel (LCIG). We aimed to analyze the impact of dysphagia on mortality in LCIG treated patients and its relationship with other PD disability milestones. METHODS: We retrospectively evaluated 95 consecutive PD patients treated with LCIG...
March 15, 2023: Parkinsonism & related Disorders
Alberto A Zellner, Gunnar T Hischebeth, Ernst Molitor, Dieter C Wirtz, Thomas M Randau
Oftentimes, Gram-positive cocci are the cause for periprosthetic joint infections (PJI). Most of these infections include bacteria such as Staphylococcus aureus, Staphylococcus epidermidis or other coagulase-negative staphylococci. We here present the first case of a PJI caused by Kytococcus schroeteri. While being a Gram-positive coccus, it is very rarely the cause for infections in the human body. K. schroeteri is part of the micrococcus branch and often encountered as a symbiotic bacterium living on the skin...
February 15, 2023: Diagnostic Microbiology and Infectious Disease
Rodrigo Saad Berreta, Helen Zhang, Daniel Alsoof, Christopher L McDonald, Bassel G Diebo, Eren Kuris, Alan H Daniels
OBJECTIVE: Spinal osteomyelitis and spondylodiscitis (SD) are infections of the vertebral body and disc, respectively, with more than 50% associated with Staphylococcus aureus. Methicillin-resistant S. aureus (MRSA) has become a pathogen of interest in cases of SD due to increasing prevalence. The purpose of this investigation was to characterize the current epidemiological and microbiological landscape in SD cases, in addition to medical and surgical challenges in treating these infections...
March 17, 2023: Journal of Neurosurgery. Spine
James Yang, Aakash Trivedi, Jamshed Zuberi
Tension pneumothorax is a condition that can present with a myriad of symptoms, including chest pain, shortness of breath, rapid breathing, and tachycardia. If left untreated, these signs and symptoms can progress to shock causing haemodynamic collapse and even death. At times, it may be difficult to identify tension pneumothorax. We present the case of a 59-year-old male with a prolonged initial hospital course that eventually led to a diagnosis of tension pneumothorax with the use of CT scans rather than traditional X-rays...
March 2023: JPMA. the Journal of the Pakistan Medical Association
Sher Muhammad Sethi, Iffat Khanum, Umair Javed, Sania Sabir
OBJECTIVE: To identify the association between acute infection and acute coronary syndrome, and to evaluate the outcomes in such cases. METHODS: The cross-sectional, retrospective, analytical study was conducted at the Aga Khan University Hospital, Karachi, from July to December 2020, and comprised data from January to December 2019 of acute coronary syndrome patients aged >18 years. Data related to demographics, comorbidities, smoking status and history of dyslipidaemia...
March 2023: JPMA. the Journal of the Pakistan Medical Association
Joyce John, Alys R Clark, Haribalan Kumar, Alain C Vandal, Kelly S Burrowes, Margaret L Wilsher, David G Milne, Brian Bartholmai, David L Levin, Ronald Karwoski, Merryn H Tawhai
Idiopathic pulmonary fibrosis (IPF) is characterised by progressive fibrosing interstitial pneumonia with an associated irreversible decline in lung function and quality of life. IPF prevalence increases with age, appearing most frequently in patients aged > 50 years. Pulmonary vessel-like volume (PVV) has been found to be an independent predictor of mortality in IPF and other interstitial lung diseases, however its estimation can be impacted by artefacts associated with image segmentation methods and can be confounded by adjacent fibrosis...
March 17, 2023: Scientific Reports
Barbara Kot, Małgorzata Piechota, Piotr Szweda, Joanna Mitrus, Jolanta Wicha, Agata Grużewska, Małgorzata Witeska
Klebsiella pneumoniae (KP) is a nosocomial pathogen causing difficult-to-treat infections. The presence of virulence genes and antibiotic resistance of 109 KP isolates from hospitalized patients were investigated. Among them, 68.8% were multi-drug resistant (MDR) and 59.6% produced extended-spectrum beta-lactamases (ESBLs). Metallo-β-lactamases (MBLs) were produced by 22% of isolates (mainly from anus), including 16.5% of isolates producing New Delhi metallo-β-lactamase (NDM-1). The genes encoding adhesins (fimH-91...
March 17, 2023: Scientific Reports
Taehee Lee, Eui Jin Hwang, Chang Min Park, Jin Mo Goo
RATIONALE AND OBJECTIVES: The role of preoperative chest radiography (CR) for prediction of postoperative pneumonia remains uncertain. We aimed to develop and validate a prediction model for postoperative pneumonia incorporating findings of preoperative CRs evaluated by a deep learning-based computer-aided detection (DL-CAD) system MATERIALS AND METHODS: This retrospective study included consecutive patients who underwent surgery between January 2019 and March 2020 and divided into development (surgery in 2019) and validation (surgery between January and March 2020) cohorts...
March 15, 2023: Academic Radiology
Jana Hirmerová, Simona Bílková, Vlastimil Woznica
Pulmonary embolism in classical meaning is a complication of deep vein thrombosis (usually in the leg veins), developing after a part of the thrombus dislodged and got wedged in pulmonary arteries. However, in half of the patients with pulmonary embolism, deep vein thrombosis is not found. One potential explanation is a different, less common location of the thrombus or previous complete embolization of the whole thrombotic mass. Another possibility is pulmonary artery thrombosis in situ, which is a specific clinical entity associated with some typical risk factors...
2023: Vnitr̆ní Lékar̆ství
Prithivi Raaj Prakash, Gaurav Gupta, Mukul Aggarwal, Upendra Baitha
We report the case of a woman in her early 20s with a history of recurrent infection, atopic dermatitis, filariasis and bilateral purulent ear discharge since childhood with tonsillar enlargement on examination. She was started on supportive care and evaluated for primary immunodeficiency disease. Blood investigations revealed increased IgM levels with reduced IgG, IgA and IgE levels. Radiological imaging of the chest revealed bilateral bronchiectasis. Otoscopic examination showed features suggestive of chronic suppurative otitis media...
March 17, 2023: BMJ Case Reports
Ashlee Stutsrim, Lucas Hunter, Cullen McCarthy, Zachary German, Timothy Craven, Donna Keith, Gabriela Velazquez-Ramirez, Matthew Edwards
INTRODUCTION: The purpose of this study is to provide an updated description of demographics, technical details and clinical outcomes of 101 consecutive branch renal artery repairs in 98 patients using cold perfusion. METHODS: Single institution, retrospective analysis branch renal artery reconstructions performed between 1987 and 2019. RESULTS: Patients were predominantly Caucasian (80.6%) women (74.5%) with mean age of 46.8 ± 15.3 years...
March 15, 2023: Journal of Vascular Surgery
Qin Si, Longga Su, Dong Wang, Bao-Jun De, Risu Na, Nagongbilige He, Tserentsoo Byambaa, Tserendagva Dalkh, Xilinqiqige Bao, Letai Yi
ETHNOPHARMACOLOGICAL RELEVANCE: The contents and types of the active compounds in medicinal herbs depend greatly on their extraction methods, sources of origin and the modes of cultivation. Platycodon grandiflorus (Jacq.) A.DC. is an ethnic medicinal herb widely cultivated in China, and its dried root, Platycodi Radix (PR), is an important ingredient in herbal formulae for attenuating lung issues in Mongolian medical practice. However, research evaluating the superiority of PR based on harvesting regions is relatively limited...
March 15, 2023: Journal of Ethnopharmacology
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