Jun Chen, Xixi Zhang, Robbie Cross, Yujin Ahn, Gillian Huskin, Will Evans, Patrick Taejoon Hwang, Jeong-A Kim, Brigitta C Brott, Hanjoong Jo, Young-Sup Yoon, Ho-Wook Jun
In vitro atherosclerosis models are essential to evaluate therapeutics before in vivo and clinical studies, but significant limitations remain, such as the lack of three-layer vascular architecture and limited atherosclerotic features. Moreover, no scalable 3D atherosclerosis model is available for making high-throughput assays for therapeutic evaluation. Herein, we report an in vitro 3D three-layer nanomatrix vascular sheet with critical atherosclerosis multi-features (VSA), including endothelial dysfunction, monocyte recruitment, macrophages, extracellular matrix remodeling, smooth muscle cell phenotype transition, inflammatory cytokine secretion, foam cells, and calcification initiation...
December 27, 2023: Biomaterials