Yu Xie, Meihua Shan, Jing Yu, Yongjun Du, Chengkun Wu, Shujing Liu, Jiayin Li, Yupeng Xiao, Yan Yan, Ning Li, Junfang Qin, Lan Lan, Yue Wang
Persistent activation of estrogen receptor alpha (ERα)-mediated estrogen signaling plays a pivotal role in driving the progression of estrogen receptor positive (ER+ ) breast cancer (BC). In the current study, LINC00173, a long non-coding RNA, was found to bind both ERα and lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNFα) factor (LITAF), then cooperatively to inhibit ERα protein degradation by impeding the nuclear export of ERα. Concurrently, LITAF was found to attenuate TNFα transcription after binding to LINC00173, and this attenuating transcriptional effect was quite significant under lipopolysaccharide stimulation...
May 5, 2024: Cancer Science