Jeannot F Zinsou, David J Diemert, Jean Claude Dejon-Agobé, Bayodé R Adégbité, Yabo Josiane Honkpehedji, Kafui G Vodonou, Rodrigue Bikangui, Jean Ronald Edoa, Marguerite Massinga Loembe, Guangzhao Li, Maria Yazdanbakhsh, Maria Elena Bottazzi, Remko van Leeuwen, Peter G Kremsner, Peter J Hotez, Jeffrey M Bethony, Martin P Grobusch, Ayola A Adegnika
BACKGROUND: A human hookworm vaccine is being developed to protect children against iron deficiency and anaemia associated with chronic infection with hookworms. Necator americanus aspartic protease-1 (Na-APR-1) and N americanus glutathione S-transferase-1 (Na-GST-1) are components of the blood digestion pathway critical to hookworm survival in the host. Recombinant Na-GST-1 and catalytically inactive Na-APR-1 (Na-APR-1[M74]) adsorbed to Alhydrogel were safe and immunogenic when delivered separately or co-administered to adults in phase 1 trials in non-endemic and endemic areas...
March 18, 2024: Lancet Infectious Diseases