Ying Jian, Tianchi Chen, Ziyu Yang, Guoxiu Xiang, Kai Xu, Yanan Wang, Na Zhao, Lei He, Qian Liu, Min Li
Staphylococcus aureus ( S. aureus ) is a notorious pathogen that cause metastatic or complicated infections. Hypervirulent ST398 clonotype strains, remarkably increased in recent years, dominated Community-associated S. aureus (CA-SA) infections in the past decade in China. Small RNAs like RNAIII have been demonstrated to play important roles in regulating the virulence of S. aureus , however, the regulatory roles played by many of these sRNAs in the ST398 clonotype strains are still unclear. Through transcriptome screening and combined with knockout phenotype analysis, we have identified a highly transcribed sRNA, RSaX28, in the ST398 clonotype strains...
April 10, 2024: Emerging Microbes & Infections