Junchao Luo, Zetao Wang, Chenqi Tang, Zi Yin, Jiayun Huang, Dengfeng Ruan, Yang Fei, Canlong Wang, Xianan Mo, Jiajin Li, Jun Zhang, Cailian Fang, Jianyou Li, Xiao Chen, Weiliang Shen
BACKGROUND: Tendinopathy is a common motor system disease that leads to pain and reduced function. Despite its prevalence, our mechanistic understanding is incomplete, leading to limited efficacy of treatment options. Animal models contribute significantly to our understanding of tendinopathy and some therapeutic options. However, the inadequacies of animal models are also evident, largely due to differences in anatomical structure and the complexity of human tendinopathy. Different animal models reproduce different aspects of human tendinopathy and are therefore suitable for different scenarios...
September 2023: Journal of Orthopaedic Translation