Sam T Albadri, Diva Salomão
INTRODUCTION: Metastatic prostatic adenocarcinoma (PAC) has mostly involved the pelvic lymph nodes; metastases to the cervical lymph nodes are exceedingly rare. MATERIALS AND METHODS: A retrospective review of cytopathology files (January 1990 to March 2019) identified 13 cases of metastatic PAC to cervical lymph nodes diagnosed using fine-needle aspiration biopsy (FNAB). The clinical and demographic information were collected from the electronic medical records, and the slides were reviewed...
August 25, 2020: Journal of the American Society of Cytopathology
Yuan Zhong, Xuhui Yang, Lianyong Jiang, Rui Hu, Zhaolei Jiang, Mingsong Wang
Background: An isolated cervical or thoracic surgical approach provides insufficient exposure for achieving complete resection of tumors of the cervicothoracic junction. This study examines reverse "L" thoracotomy as a surgical approach to these tumors. Additionally, the feasibility, safety, and effectiveness of reverse "L" surgical incision for tumor resection was also analyzed. Methods: Patients with cervicothoracic tumors were identified from an internal database...
August 2020: Journal of Thoracic Disease
Joseph J Noh, Myong Cheol Lim, Moon-Hong Kim, Yun Hwan Kim, Eun Seop Song, Seok Ju Seong, Dong Hoon Suh, Jong-Min Lee, Chulmin Lee, Chel Hun Choi
The aim of the present study was to investigate the prognostic role of the pre-treatment complete blood count (CBC) profile as a predictive marker of survival, recurrence, and death in early stage squamous cell carcinoma and adenocarcinoma of the cervix. The pre-treatment CBC profiles of the patients from nine tertiary medical centers in South Korea who were treated surgically for early stage cervical cancer were reviewed. Statistical models by the Akaike's information criterion (AIC) were developed using CBC profiles to calculate individuals' risk scores for clinical outcomes...
September 13, 2020: Journal of Clinical Medicine
Cynthia M Chweya, Christopher M Low, Jamie J Van Gompel, Kathryn M Van Abel, Janalee K Stokken, Garret Choby
BACKGROUND: Minimal information has been reported on the effect of distant and nodal metastases at the time of diagnosis on survival in patients with sinonasal adenocarcinoma (SNAC). METHODS: The Surveillance, Epidemiology, and End Results database was utilized to compare overall survival (OS) and disease-specific survival (DSS). RESULTS: Of the 325 patients with SNAC identified, 5-year and 10-year OS for all included patients was 64% and 58%, respectively...
September 15, 2020: Head & Neck
Xing Zhao, Yulu Qin, Xingbin Shen, Gang Zhang
Located in the uterine cervix, cervical invasive stratified mucin-producing carcinoma (i-SMILE) is a rare, recently-identified tumor about which little is known. In extremely rare cases, other kinds of invasive carcinoma can accompany i-SMILE, such as squamous cell carcinoma (SCC) and adenocarcinoma, with different proportions. Here, we report a case of cervical carcinoma coexisting with i-SMILE, mucinous carcinoma, non-specific type (NOS), and SCC. We review the pathological diagnosis and describe the clinical pathological characteristics...
2020: International Journal of Clinical and Experimental Pathology
Xiaoyue Chen, Lan Chen, Haiyan Zhu, Jie Tao
Background: The most common metastatic site in cervical cancers is lung. The aim of this study is to identify cervical cancer patients with high risk for developing lung metastasis and further explore their prognosis. Materials and Methods: At first, patients diagnosed with cervical cancer from 2010 to 2015 were identified from The Surveillance, Epidemiology, and End Results (SEER) database. Multivariate logistic and Cox regression models were used to identify risk and prognostic factors in cervical cancer patients with lung metastasis...
2020: Journal of Cancer
Danny Rischin, Marta Gil-Martin, Antonio González-Martin, Irene Braña, June Y Hou, Daniel Cho, Gerald S Falchook, Silvia Formenti, Salma Jabbour, Kathleen Moore, Aung Naing, Kyriakos P Papadopoulos, Joaquina Baranda, Wen Fury, Minjie Feng, Elizabeth Stankevich, Jingjin Li, N Alice Yama-Dang, Suk-Young Yoo, Israel Lowy, Melissa Mathias, Matthew G Fury
OBJECTIVES: To characterize the safety, tolerability, and anti-tumor activity of cemiplimab as monotherapy or in combination with hypofractionated radiation therapy (hfRT) in patients with recurrent or metastatic cervical cancer. To determine the association between histology and programmed death-ligand 1 (PD-L1) expression. METHODS: In non-randomized phase I expansion cohorts, patients (squamous or non-squamous histology) received cemiplimab 3 mg/kg intravenously every 2 weeks for 48 weeks, either alone (monotherapy cohort) or with hfRT during week 2 (combination cohort)...
September 8, 2020: Gynecologic Oncology
Chih-Chun Wang, Ben-Kuen Chen, Peng-Hsu Chen, Lei-Chin Chen
OBJECTIVE: The aim of this study was to examine the antitumor activity of hinokitiol for its clinical application in the treatment of human cervical carcinoma. MATERIALS AND METHODS: Cervical carcinoma HeLa cells were treated by different concentrations of hinokitiol. Flow cytometry was used to analyze cell cycle. Senescence-associated β-galactosidase (SA-β-gal) assay was used to identify senescent cells. The effects of hinokitiol on EGF-induced cell migration were determined by wound healing and transwell migration assays...
September 2020: Taiwanese Journal of Obstetrics & Gynecology
Malika Kengsakul, Tarinee Manchana
OBJECTIVE: To determine the incidence of coexisting cancers in women with glandular cell abnormalities detected from liquid-based cytology and to compare the detection rate of premalignant and malignant lesions among various subtypes of glandular cell abnormalities. MATERIALS AND METHODS: From January 2014 to December 2016, liquid-based cytology was performed in 85,517 women. Using the Bethesda system 2001 criteria, abnormal cervical cytology was diagnosed in 3650 women (4...
September 2020: Taiwanese Journal of Obstetrics & Gynecology
Giorgio Bogani, Francesco Sopracordevole, Jvan Casarin, Ciro Pinelli, Umberto Leone Roberti Maggiore, Claudia Brusadelli, Rocco Guerrisi, Antonino Ditto, Andrea Dell'Acqua, Maurizio Serati, Salvatore Lopez, Simone Ferrero, Fabio Ghezzi, Francesco Raspagliesi
OBJECTIVE: To evaluate the impact of various HPV types on the risk of developing lesions of the uterus (either uterine cervix and endometrium) in women diagnosed with "atypical glandular cells" (AGC) at Pap smear. METHODS: This is a multi-institutional retrospective study. Data of women diagnosed with AGC were retrospectively reviewed. All patients included had data about HPV DNA testing and 1-year clinical follow-up. RESULTS: Overall, chart of 480 patients were evaluated...
August 24, 2020: Pathology, Research and Practice
Shailee P Mehta, Trupti S Patel, Torsha Jana, Satarupa T Samanta, Rujuta Malvania, Priti P Trivedi, Swati Girdher
OBJECTIVE: To determine the role of routine cervical Pap smears in detecting endometrial carcinomas. METHOD: A retrospective study was carried out from the histopathology archives for cases diagnosed as endometrial carcinomas with Pap smears within 6 months before histological diagnosis. The demographic details, reports of Pap smears and other tumor parameters on histopathology were noted. RESULTS: We identified 380 of 482 cases of endometrial carcinoma with a documented Pap smear within 6 months before histopathogical diagnosis...
September 10, 2020: Diagnostic Cytopathology
Leonie Hartl, JanWillem Duitman, Hella L Aberson, Kan Chen, Frederike Dijk, Joris J T H Roelofs, Mark P G Dings, Gerrit K J Hooijer, Pratika Y Hernanda, Qiunwei Pan, Olivier R Busch, Marc G H Besselink, Ton Boerman, Maikel P Peppelenbosch, Maarten F Bijlsma, C Arnold Spek
CCAAT/enhancer-binding protein δ (C/EBPδ) is a transcription factor involved in growth arrest and differentiation, which has consequently been suggested to harbor tumor suppressive activities. However, C/EBPδ over-expression correlates with poor prognosis in glioblastoma and promotes genomic instability in cervical cancer, hinting at an oncogenic role of C/EBPδ in these contexts. Here, we explore the role of C/EBPδ in pancreatic cancer. We determined C/EBPδ expression in biopsies from pancreatic cancer patients using public gene-expression datasets and in-house tissue microarrays...
September 7, 2020: Cancers
Jie Yang, Carolyn Mead-Harvey, Clarissa Polen-De, Paul Magtibay, Kristina Butler, William Cliby, Carrie Langstraat, Tri Dinh, Longwen Chen, Javier Magrina
OBJECTIVE: To compare the survival outcomes and surgical radicality between women who underwent open versus robotic radical hysterectomy (RH) for early cervical cancer. METHODS: In this institutional retrospective study, patients with clinical stage IA2- IIA (FIGO 2009) squamous cell, adenocarcinoma and adenosquamous carcinoma of the cervix who underwent either open or robotic RH between 2000 and 2017 were identified. Parametrial width and vaginal length were re-measured from pathology slides...
September 3, 2020: Gynecologic Oncology
Hisanori Kobara, Tsutomu Miyamoto, Hirofumi Ando, Ryoichi Asaka, Akiko Takatsu, Ayumi Ohya, Shiho Asaka, Tanri Shiozawa
INTRODUCTION: Although lobular endocervical glandular hyperplasia is a benign disorder of the uterine cervix, its potential as a precursor of minimal deviation adenocarcinoma has been reported. However, the natural history of the disease and the frequency of malignant change are not fully understood. We evaluated the frequency of malignant change of clinical lobular endocervical glandular hyperplasia and explored useful parameters indicating malignant change. METHODS: The clinical courses of 175 patients with cervical multi-cystic lesions who visited Shinshu University Hospital between June 1995 and June 2019 were retrospectively analyzed...
September 3, 2020: International Journal of Gynecological Cancer
Swati Satturwar, Chengquan Zhao, Robert Marshall Austin
OBJECTIVES: Cervical stenosis can jeopardize adequate posttreatment cytologic follow-up of patients treated for high-grade cervical intraepithelial lesions. An impact on human papillomavirus (HPV) testing has not been described. MATERIALS AND METHODS: We describe 2 patients with cervical stenosis, followed by cytology and HPV co-testing after excisions of high-grade cervical intraepithelial lesions. Each had 1 or more co-test "double-negative" results...
August 31, 2020: Journal of Lower Genital Tract Disease
Metlapalli Venkata Sravanthi, Sharmil Suma Kumaran, Abhinav Palle, Padmaja Bojanapally
With more women getting pregnant at later ages than in the past, the incidence of malignancies in pregnancy is on the rise. Common malignancies of pregnancy are melanoma, breast cancer, cervical cancer, lymphomas, and leukemias. Colorectal carcinoma is rare in pregnancy, with an estimated incidence of 1 in 13',000 cases. We describe such a case of colorectal carcinoma in pregnancy (CRC-p), in a 31-year-old patient. She presented in the 21st  week of her second pregnancy with constipation of two weeks duration despite appropriate medical management...
July 31, 2020: Curēus
Stacey J Scott, Kethan S Suvarna, Pier Paolo D'Avino
Human retinal pigment ephitilial-1 (RPE-1) cells are increasingly being used as a model to study mitosis because they represent a non-transformed alternative to cancer cell lines, such as HeLa cervical adenocarcinoma cells. However, the lack of an efficient method to synchronize RPE-1 cells in mitosis precludes their application for large-scale biochemical and proteomics assays. Here we report a protocol to synchronize RPE-1 cells based on sequential treatments with the Cdk4/6 inhibitor PD 0332991 (palbociclib) and the microtubule depolymerizing drug nocodazole...
September 2, 2020: Journal of Cell Science
Agnieszka Lewandowska, Sebastian Szubert, Krzysztof Koper, Agnieszka Koper, Grzegorz Cwynar, Lukasz Wicherek
BACKGROUND: Pelvic exenteration (PE) may be associated with prolonged overall survival (OS) in selected patients with advanced or recurrent cervical cancer. However, the factors related to improved survival following PE are not clearly defined. The aim of this study was to perform a retrospective analysis of OS rates in a group of patients undergoing PE in order to identify the factors related to improved long-term outcomes. METHODS: Our study group consisted of 44 patients, including 21 squamous cell cancer (SCC) patients, 22 patients with adenocarcinomas (AC) of the cervix, and one patient with undifferentiated cervical carcinoma...
September 2, 2020: World Journal of Surgical Oncology
Yoshihisa Arakaki, Takuro Ariga, Joichi Heianna, Yuko Shimoji, Tadaharu Nakasone, Yusuke Taira, Tomoko Nakamoto, Takuma Ooyama, Wataru Kudaka, Itomi Kaneshima, Kumiko Nishihira, Keiko Mekaru, Yoichi Aoki
BACKGROUND/AIM: We retrospectively analyzed the locally advanced adenocarcinoma (AC)/adenosquamous carcinoma (ASC) of the uterine cervix treated with concurrent chemoradiotherapy using cisplatin plus paclitaxel (TP-CCRT). PATIENTS AND METHODS: Thirty patients with stage IB-IVA AC/ASC were treated with whole pelvis external beam radiotherapy. A high-dose-rate intracavitary brachytherapy was delivered once per week at a fractional dose of 6 Gy. For TP-CCRT, the patients received cisplatin and paclitaxel...
September 2020: In Vivo
Michael Chahin, Nithya Krishnan, Trevanne Matthews-Hew, Jason Hew, Dat Pham
Lung cancer is a worldwide concern and is the leading cause of cancer-related death in the United States. Adenocarcinoma is the most common type of non-small cell lung cancer; however, unlike other types of lung cancer this disease is often seen in light tobacco smokers and non-smokers. The presence of driver mutations, such as the epidermal growth factor receptor (EGFR) and echinoderm microtubule-associated protein-like 4 (EML-4)-anaplastic lymphoma kinase (ALK) rearrangement, appears to be more common in these patients...
July 28, 2020: Curēus
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