Lixia Zhang, Kyu Hwan Kwack, Ramkumar Thiyagarajan, Kylie K Mullaney, Natalie A Lamb, Jonathan E Bard, Jiho Sohn, Kenneth L Seldeen, Yukitomo Arao, Perry J Blackshear, Scott I Abrams, Bruce R Troen, Keith L Kirkwood
Tristetraprolin (TTP; also known as NUP475, GOS24, or TIS11), encoded by Zfp36, is an RNA-binding protein that regulates target gene expression by promoting mRNA decay and preventing translation. Although previous studies have indicated that TTP deficiency is associated with systemic inflammation and a catabolic-like skeletal phenotype, the mechanistic underpinnings remain unclear. Here, using both TTP-deficient (TTPKO) and myeloid-specific TTPKO (cTTPKO) mice, we reveal that global absence or loss of TTP in the myeloid compartment results in a reduced bone microarchitecture, whereas gain-of-function TTP knock-in (TTPKI) mice exhibit no significant loss of bone microarchitecture...
January 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology