Masayuki Tsukasaki
Periodontitis, one of the most common infectious diseases in humans, is characterized by inflammation of the periodontal tissue and subsequent destruction of the alveolar bone, which ultimately leads to tooth loss. Recently, it was revealed that the osteoclastic bone damage that occurs during periodontitis is dependent on the receptor activator of NF-kB ligand (RANKL) produced by osteoblastic cells and periodontal ligament cells. Immune cells provide essential cues for the RANKL induction that takes place during periodontal inflammation...
October 17, 2020: Journal of Bone and Mineral Metabolism
Li Zhang, El-Mustapha Haddouti, Kristian Welle, Christof Burger, Koroush Kabir, Frank A Schildberg
Over the last decades, joint arthroplasty has become a successful treatment for joint disease. Nowadays, with a growing demand and increasingly younger and active patients accepting these approaches, orthopedic surgeons are seeking implants with improved mechanical behavior and longer life span. However, aseptic loosening as a result of wear debris from implants is considered to be the main cause of long-term implant failure. Previous studies have neatly illustrated the role of micrometric wear particles in the pathological mechanisms underlying aseptic loosening...
2020: International Journal of Nanomedicine
Anqi Zhou, Hui Yu, Jiayi Liu, Jianan Zheng, Yinan Jia, Bingfeng Wu, Lin Xiang
The social demand for dental implantation is growing at a rapid rate, while dentists are faced with the dilemma of implantation failures associated with unfavorable osseointegration. Clinical-friendly osteogenesis, angiogenesis and osteoimmunology around dental implants play a pivotal role in a desirable osseointegration and it's increasingly appreciated that Hippo-YAP signaling pathway is implicated in those biological processes both in vitro and in vivo in a variety of study. In this article we review the multiple effects of Hippo-YAP signaling in osseointegration of dental implants by regulating osteogenesis, angiogenesis and osteoimmunology in peri-implant tissue, as well as highlight prospective future directions of relevant investigation...
2020: Frontiers in Cell and Developmental Biology
Shangfu Li, Qiuli Liu, Depeng Wu, Tianwei He, Jinbo Yuan, Heng Qiu, Jennifer Tickner, Song Guo Zheng, Xiaojuan Li, Jiake Xu, Limin Rong
PKC-δ is an important molecule for B-cell proliferation and tolerance. B cells have long been recognized to play a part in osteoimmunology and pathological bone loss. However, the role of B cells with PKC-δ deficiency in bone homeostasis and the underlying mechanisms are unknown. We generated mice with PKC-δ deletion selectively in B cells by crossing PKC-δ-loxP mice with CD19-Cre mice. We studied their bone phenotype using micro-CT and histology. Next, immune organs were obtained and analyzed. Western blotting was used to determine the RANKL/OPG ratio in vitro in B-cell cultures, ELISA assay and immunohistochemistry were used to analyze in vivo RANKL/OPG balance in serum and bone sections respectively...
September 16, 2020: Cell Death & Disease
Gianmaria Salvio, Claudio Gianfelice, Francesca Firmani, Stefano Lunetti, Giancarlo Balercia, Gilberta Giacchetti
Even though inflammatory conditions are known to exert adverse effects on bone metabolism, there are no published data regarding SARS-CoV-2 infection and subsequent fracture risk. We present a brief review of the molecular mechanisms linking inflammatory diseases to increased fracture risk/osteoporosis and of the therapeutic strategies that can prevent bone resorption in patients with inflammatory disease, focusing on the RANK-RANKL system. We also make some considerations on gender differences in infection response and on their implications for survival and for the consequences of COVID-19...
September 1, 2020: Clinical Reviews in Bone and Mineral Metabolism
Wenjuan Zhang, Kai Dang, Ying Huai, Airong Qian
Immune imbalance caused bone loss. Osteoimmunology is emerging as a new interdisciplinary field to explore the shared molecules and interactions between the skeletal and immune systems. In particular, T lymphocytes (T cells) play pivotal roles in the regulation of bone health. However, the roles and mechanisms of T cells in the treatment of osteoporosis are not fully understood. The present review aims to summarize the essential regulatory roles of T cells in the pathophysiology of various cases of osteoporosis and the development of T cell therapy for osteoporosis from osteoimmunology perspective...
2020: Frontiers in Endocrinology
Ziqing Li, Puyi Sheng, Chaohong Li, Gongsheng Yuan, Yilun Deng
No abstract text is available yet for this article.
2020: BioMed Research International
Stinne R Greisen, Tue W Kragstrup, Jesper Skovhus Thomsen, Aida Solhøj Hansen, Akilan Krishnamurthy, Kim Hørslev-Petersen, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Lykke Midtbøll Ørnbjerg, Peter Junker, Arlene H Sharpe, Gordon J Freeman, Lakshmanan Annamalai, Malene Hvid, Søren K Moestrup, Ellen-Margrethe Hauge, Anca Irinel Catrina, Bent Deleuran
Objective: Active rheumatoid arthritis (RA) is accompanied by increased appendicular and axial bone loss, closely associated to the degree of inflammation. The programmed death-1 (PD-1) pathway is important for maintaining peripheral tolerance, and its ligand PD-L2 has recently been associated with bone morphogenetic protein activity. Here, we report that PD-L2 plays a central role in RA osteoimmunology. Methods: Femoral bone mineral density (BMD) and trabecular bone microstructure were evaluated by micro-CT in wild type (WT) and PD-L2-/- mice...
2020: Journal of translational autoimmunity
O A Zorina, M A Amkhadova, A A Khamukova, E Sh Aleskerov, G A Ajrapetov, A A Demidova
THE AIM OF THE STUDY: Was to analyze possible correlation between the concentration of the pro-inflammatory cytokine interleukin-6 and the activation marker of osteoclasts cathepsin K in the gingival fluid during osteoresorption of inflammatory (periimplantitis, chronic generalized periodontitis) and malignant oncological origin (malignant neoplasm of gums). MATERIALS AND METHODS: The study comprised 87 individuals of both sexes aged 30 to 60: 20 patients (group 1) with periimplantitis, 30 people with chronic generalized periodontitis (CGP) (group 2), 22 patients with squamous cell carcinoma of the upper and lower alveolar bone gingiva (group 3), 15 healthy individuals without periodontal disease...
2020: Stomatologii︠a︡
Preeti J Muire, Lauren H Mangum, Joseph C Wenke
Single trauma injuries or isolated fractures are often manageable and generally heal without complications. In contrast, high-energy trauma results in multi/poly-trauma injury patterns presenting imbalanced pro- and anti- inflammatory responses often leading to immune dysfunction. These injuries often exhibit delayed healing, leading to fibrosis of injury sites and delayed healing of fractures depending on the intensity of the compounding traumas. Immune dysfunction is accompanied by a temporal shift in the innate and adaptive immune cells distribution, triggered by the overwhelming release of an arsenal of inflammatory mediators such as complements, cytokines and damage associated molecular patterns (DAMPs) from necrotic cells...
2020: Frontiers in Immunology
Lu Liu, Fujian Zhao, Xiaoyu Chen, Man Luo, Zhen Yang, Xiaodong Cao, Guohou Miao, Dafu Chen, Xiaofeng Chen
The addition of osteoimmunology drugs to bone repair materials is beneficial to bone regeneration by regulating the local immune microenvironment. Fingolimod (FTY720) has been reported to be an osteoimmunology drug that promotes osteogenesis. However, there is no ideal biomaterial for the sustained release of FTY720 in the bone defect areas. In the present work, FTY720 loaded mesoporous bioactive glass (FTY720@MBGs) was successfully prepared based on the mesoporous properties of MBGs and electrostatic attraction...
June 22, 2020: Journal of Materials Chemistry. B, Materials for Biology and Medicine
Sung-Lin Hu, Chien-Chung Huang, Tzu-Ting Tzeng, Shan-Chi Liu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Hsin Tang
Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, in which the immune system attacks joint tissue. Interleukin (IL)-6 is a key proinflammatory cytokine in RA progression. Sphingosine-1-phosphate (S1P), a platelet-derived lysophospholipid mediator, reportedly regulates osteoimmunology. Here, we examined the effects of S1P on IL-6 expression in osteoblasts. Our results and records from the Gene Expression Omnibus (GEO) database demonstrate higher levels of IL-6 in patients with RA compared with those with osteoarthritis...
2020: International Journal of Medical Sciences
Yajuan Xie, Cheng Hu, Yi Feng, Danfeng Li, Tingting Ai, Yulei Huang, Xiaodan Chen, Lijia Huang, Jiali Tan
Biomaterials as bone substitutes are always considered as foreign bodies that can trigger host immune responses. Traditional designing principles have been always aimed at minimizing the immune reactions by fabricating inert biomaterials. However, clinical evidence revealed that those methods still have limitations and many of which were only feasible in the laboratory. Currently, osteoimmunology, the very pioneering concept is drawing more and more attention-it does not simply regard the immune response as an obstacle during bone healing but emphasizes the intimate relationship of the immune and skeletal system, which includes diverse cells, cytokines, and signaling pathways...
June 2020: Regenerative Biomaterials
Syed Saad B Qasim, Dalal Al-Otaibi, Reham Al-Jasser, Sarhang S Gul, Muhammad Sohail Zafar
Several investigators have reported about the intricate molecular mechanism underlying periodontal diseases (PD). Nevertheless, the role of specific genes, cells, or cellular mechanisms involved in the pathogenesis of periodontitis are still unclear. Although periodontitis is one of the most prevalent oral diseases globally, there are no pre-diagnostic markers or therapeutic targets available for such inflammatory lesions. A pivotal role is played by pro- and anti-inflammatory markers in modulating pathophysiological and physiological processes in repairing damaged tissues...
May 28, 2020: International Journal of Molecular Sciences
Sung-Lin Hu, Chien-Chung Huang, Tzu-Ting Tseng, Shan-Chi Liu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Hsin Tang
Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, in which the immune system attacks synovial joint tissues. Interleukin (IL)-1β is a critical proinflammatory cytokine in RA progression. Sphingosine-1-phosphate (S1P), a platelet-derived lysophospholipid mediator, reportedly regulates osteoimmunology. Here, we investigated how S1P mediates IL-1β expression in osteoblasts. Our analysis of records from the Gene Expression Omnibus (GEO) database demonstrate higher levels of IL-1β in patients with RA compared with those with osteoarthritis...
May 13, 2020: Environmental Toxicology
Yingzhi Gu, Xiaozhe Han
Periodontitis is known to be initiated by periodontal microbiota derived from biofilm formation. The microbial dysbiotic changes in the biofilm trigger the host immune and inflammatory responses that can be both beneficial for the protection of the host from infection, and detrimental to the host, causing tissue destruction. During this process, recognition of Pathogen-Associated Molecular Patterns (PAMPs) by the host Pattern Recognition Receptors (PRRs) such as Toll-like receptors (TLRs) play an essential role in the host-microbe interaction and the subsequent innate as well as adaptive responses...
May 8, 2020: International Journal of Molecular Sciences
Xiuwen Wang, Xiang Chen, Lingyun Lu, Xijie Yu
BACKGROUND: Chronic consumption of alcohol has an adverse effect on the skeletal system, which may lead to osteoporosis, delayed fracture healing and osteonecrosis of the femoral head. Currently, treatment is limited. It is urgent to determine the underline mechanism and invent new treatment. It is well known that normal bone remodeling relies on the balance between osteoclastmediated bone resorption and osteoblast-mediated bone formation. Many factors can destroy the balance, including dysfunction of immune system...
April 25, 2020: Current Medicinal Chemistry
Anita Ignatius, Cristina Sobacchi
No abstract text is available yet for this article.
2020: Frontiers in Immunology
Hiroshi Takayanagi
Bone is a critically important part of the skeletal system that is essential for body support and locomotion. The immune system protects against pathogens and is active in host defense. These two seemingly distinct systems in fact interact with each other, share molecules and create a collaborative regulatory system called the "osteoimmune system". The most representative osteoimmune molecule is receptor activator of NF-κB ligand (RANKL), which plays multiple roles in the osteoimmune system under both physiological and pathological conditions such as rheumatoid arthritis and cancer metastasis to bone...
2020: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Giacomina Brunetti, Patrizia D'Amelio, Giorgio Mori, Maria Felicia Faienza
No abstract text is available yet for this article.
2020: Frontiers in Endocrinology
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