Yikuan Du, Zhuoming Guo, Bijun Xu, Yujia Yang, Mianda Hu, Yanghui Hu, Yurong Yang, Mengting Zhang, Zhenjie Wang, Xiaochun Guo, Yixing Huang, Jinfeng Zhu, Weichui Zhang, Chun Yang
INTRODUCTION: Ibuprofen is commonly used as an over-the-counter (OTC) antipyretic and analgesic. As the frequency of its use increases, there has been a corresponding increase in reports of associated adverse events (AEs). However, these events have not been systematically reported in the literature. Meanwhile, the importance of effective pharmacovigilance in evaluating the benefits and risks of drugs is being recognized. METHODS: Data were obtained indirectly from FAERS using the OpenVigil 2 database, lexically mapped using software such as MySQL, Microsoft Excel, and the R language, and then subjected to four more rigorous algorithms to detect risk signals associated with ibuprofen AEs...
April 30, 2024: Expert Opinion on Drug Safety