Matthew Glass, Zhicheng Ji, Richard Davis, Elizabeth Pavlisko, Louis DiBernardo, John Carney, Gregory Fishbein, Daniel Luthringer, Dylan Miller, Richard Mitchell, Brandon Larsen, Yasmeen Butt, Melanie Bois, Joseph Maleszewski, Marc Halushka, Michael Seidman, Chieh-Yu Lin, Maximilian Buja, James Stone, David Dov, Lawrence Carin, Carolyn Glass
BACKGROUND: Pathologic antibody mediated rejection (pAMR) remains a major driver of graft failure in cardiac transplant patients. The endomyocardial biopsy remains the primary diagnostic tool but presents with challenges, particularly in distinguishing the histologic component (pAMR-H) defined by 1) intravascular macrophage accumulation in capillaries and 2) activated endothelial cells that expand the cytoplasm to narrow or occlude the vascular lumen. Frequently, pAMR-H is difficult to distinguish from acute cellular rejection (ACR) and healing injury...
April 25, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology