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Shuo Sun, Ming Wang, Sarah A Knupp, Yadira Soto-Feliciano, Xiao Hu, David L Kaplan, Robert Langer, Daniel G Anderson, Qiaobing Xu
No abstract text is available yet for this article.
June 28, 2023: Bioconjugate Chemistry
#42
JOURNAL ARTICLE
Shriya S Srinivasan, Lisa Gfrerer, Paramesh Karandikar, Avik Som, Amro Alshareef, Sabrina Liu, Haley Higginbotham, Keiko Ishida, Alison Hayward, Sanjeeva P Kalva, Robert Langer, Giovanni Traverso
BACKGROUND: While peripheral nerve stimulation (PNS) has shown promise in applications ranging from peripheral nerve regeneration to therapeutic organ stimulation, clinical implementation has been impeded by various technological limitations, including surgical placement, lead migration, and atraumatic removal. METHODS: We describe the design and validation of a platform technology for nerve regeneration and interfacing: adaptive, conductive, and electrotherapeutic scaffolds (ACESs)...
June 9, 2023: Med
#43
JOURNAL ARTICLE
Joshua C Doloff, Minglin Ma, Atieh Sadraei, Hok Hei Tam, Shady Farah, Jennifer Hollister-Lock, Arturo J Vegas, Omid Veiseh, Victor M Quiroz, Amanda Rakoski, Stephanie Aresta-DaSilva, Andrew R Bader, Marissa Griffin, Gordon C Weir, Michael A Brehm, Leonard D Shultz, Robert Langer, Dale L Greiner, Daniel G Anderson
Biomedical devices comprise a major component of modern medicine, however immune-mediated fibrosis and rejection can limit their function over time. Here, we describe a humanized mouse model that recapitulates fibrosis following biomaterial implantation. Cellular and cytokine responses to multiple biomaterials were evaluated across different implant sites. Human innate immune macrophages were verified as essential to biomaterial rejection in this model and were capable of cross-talk with mouse fibroblasts for collagen matrix deposition...
June 16, 2023: Science Advances
#44
JOURNAL ARTICLE
Pedro P G Guimarães, Christian G Figueroa-Espada, Rachel S Riley, Ningqiang Gong, Lulu Xue, Tomasz Sewastianik, Peter S Dennis, Claudia Loebel, Amanda Chung, Sarah J Shepherd, Rebecca M Haley, Alex G Hamilton, Rakan El-Mayta, Karin Wang, Robert Langer, Daniel G Anderson, Ruben D Carrasco, Michael J Mitchell
Multiple myeloma (MM), a hematologic malignancy that preferentially colonizes the bone marrow, remains incurable with a survival rate of 3 to 6 mo for those with advanced disease despite great efforts to develop effective therapies. Thus, there is an urgent clinical need for innovative and more effective MM therapeutics. Insights suggest that endothelial cells within the bone marrow microenvironment play a critical role. Specifically, cyclophilin A (CyPA), a homing factor secreted by bone marrow endothelial cells (BMECs), is critical to MM homing, progression, survival, and chemotherapeutic resistance...
June 20, 2023: Proceedings of the National Academy of Sciences of the United States of America
#45
REVIEW
Herjan J T Coelingh Bennink, Iman J Schultz, Marcus Schmidt, V Craig Jordan, Paula Briggs, Jan F M Egberts, Kristina Gemzell-Danielsson, Ludwig Kiesel, Kirsten Kluivers, Jan Krijgh, Tommaso Simoncini, Frank Z Stanczyk, Robert D Langer
Many factors, including reproductive hormones, have been linked to a woman's risk of developing breast cancer (BC). We reviewed the literature regarding the relationship between ovulatory menstrual cycles (MCs) and BC risk. Physiological variations in the frequency of MCs and interference with MCs through genetic variations, pathological conditions and or pharmaceutical interventions revealed a strong link between BC risk and the lifetime number of MCs. A substantial reduction in BC risk is observed in situations without MCs...
May 30, 2023: Breast Cancer Research: BCR
#46
JOURNAL ARTICLE
Giovanni Herrera-Mora, Pablo Solis-Chaves, Georgina Hernandez-Aviles, Emma-Jane M Graham, Christine Clausen-Oreamuno, Jose Andres Castro-Cespedes, Jennifer Haupt, Morgan Jamiel, Omid Veiseh, Marcos Sforza, John Hancock, Brian Kinney, Roberto De Mezerville, Robert Langer, Joshua C Doloff, Manuel Chacon-Quiros
BACKGROUND: Breast implant safety issues have resulted in the need for global product recalls and medical device tracing. Conventional methods of breast implant tracing, have to date proven to be unsuccessful. This study aims to evaluate the effectiveness of HRUS screening in identifying implanted breast devices. METHODS: Data from 113 female patients undergoing pre-operative ultrasound screening for secondary breast surgery between 2019 and 2022 was prospectively reviewed to evaluate the effectiveness of HRUS imaging with the aid of a Sonographic Surface Catalog to identify the surface and brand type of implanted breast devices...
May 24, 2023: Plastic and Reconstructive Surgery
#47
JOURNAL ARTICLE
Othman Bin-Alamer, Jumanah Qedair, Paolo Palmisciano, Arka N Mallela, Gautam M Nayar, Victor M Lu, Mohamed A Labib, Michael J Lang, Bradley A Gross, David J Langer, William T Couldwell, Robert M Friedlander, Hussam Abou-Al-Shaar
OBJECTIVE: The aim of this study was to describe the efficacy, clinical outcomes, and complications of open cerebrovascular surgery, endovascular surgery, and conservative management of dolichoectatic vertebrobasilar aneurysms (DVBAs). METHODS: Relevant articles were retrieved from PubMed, Scopus, Web of Science, and Cochrane databases according to PRISMA guidelines. A meta-analysis was conducted for clinical presentation, treatment protocols, and clinical outcomes-good (improved or stable clinical status) or poor (deteriorated clinical status or death)-and mortality rates...
May 2023: Neurosurgical Focus
#48
JOURNAL ARTICLE
Frerk-Ulfert Wehmeyer, Robert Langer
Pre-coordination to a transition metal by the terminal donor groups of a tri-dentate ligand is a common strategy to stabilise elusive groups, to achieve unprecedented bond activation and to develop novel modes of metal-ligand-cooperation for catalysis. In the current manuscript, we demonstrate that the oxidative addition of a central E-H-bond after pre-coordination to the metal centre is disfavoured for metals with d10 electron configuration. For exemplary pincer ligands and metals with d10 electron configuration, quantum chemical calculations suggest a second barrier, which is associated with the rearrangement of the saw-horse structure, obtained after oxidative addition, to the expected square planar geometry for the resulting d8 electron configuration...
April 28, 2023: Chemical Communications: Chem Comm
#49
JOURNAL ARTICLE
Jadwiga Gabor, Grzegorz Mikrut, Tomasz Flak, Patryk Cebo, Robert Roczniok, Beata Swinarew, Ewa Langer, Magdalena Popczyk, Arkadiusz Stanula, Sebastian Stach, Andrzej S Swinarew
The use of modern materials in sports, in terms of chemical composition and surface texture, entails both progress in results and an increasing discrepancy in the technical parameters of the equipment used. This paper aims to demonstrate the differences between balls admitted to a league and world championships in composition, surface texture, and the influence of these parameters on the water polo game. This research compared two new balls produced by top companies producing sports accessories (Kap 7 and Mikasa)...
April 12, 2023: Materials
#50
JOURNAL ARTICLE
Aurélien Vander Straeten, Morteza Sarmadi, John L Daristotle, Maria Kanelli, Lisa H Tostanoski, Joe Collins, Apurva Pardeshi, Jooli Han, Dhruv Varshney, Behnaz Eshaghi, Johnny Garcia, Timothy A Forster, Gary Li, Nandita Menon, Sydney L Pyon, Linzixuan Zhang, Catherine Jacob-Dolan, Olivia C Powers, Kevin Hall, Shahad K Alsaiari, Morris Wolf, Mark W Tibbitt, Robert Farra, Dan H Barouch, Robert Langer, Ana Jaklenec
Decentralized manufacture of thermostable mRNA vaccines in a microneedle patch (MNP) format could enhance vaccine access in low-resource communities by eliminating the need for a cold chain and trained healthcare personnel. Here we describe an automated process for printing MNP Coronavirus Disease 2019 (COVID-19) mRNA vaccines in a standalone device. The vaccine ink is composed of lipid nanoparticles loaded with mRNA and a dissolvable polymer blend that was optimized for high bioactivity by screening formulations in vitro...
April 24, 2023: Nature Biotechnology
#51
Maria Kanelli, Neelkanth M Bardhan, Morteza Sarmadi, Shahad Alsaiari, William T Rothwell, Apurva Pardeshi, Dominique C De Fiesta, Howard Mak, Virginia Spanoudaki, Nicole Henning, Jooli Han, Angela M Belcher, Robert S Langer, Ana Jaklenec
Cancer therapy research is of high interest because of the persistence and mortality of the disease and the side effects of traditional therapeutic methods, while often multimodal treatments are necessary based on the patient's needs. The development of less invasive modalities for recurring treatment cycles is thus of critical significance. Herein, a light-activatable microparticle system was developed for localized, pulsatile delivery of anticancer drugs with simultaneous thermal ablation, by applying controlled ON-OFF thermal cycles using near-infrared laser irradiation...
April 16, 2023: bioRxiv
#52
JOURNAL ARTICLE
Sachin H Bhagchandani, Farrukh Vohidov, Lauren E Milling, Evelyn Yuzhou Tong, Christopher M Brown, Michelle L Ramseier, Bin Liu, Timothy B Fessenden, Hung V-T Nguyen, Gavin R Kiel, Lori Won, Robert S Langer, Stefani Spranger, Alex K Shalek, Darrell J Irvine, Jeremiah A Johnson
Imidazoquinolines (IMDs), such as resiquimod (R848), are of great interest as potential cancer immunotherapies because of their ability to activate Toll-like receptor 7 (TLR7) and/or TLR8 on innate immune cells. Nevertheless, intravenous administration of IMDs causes severe immune-related toxicities, and attempts to improve their tissue-selective exposure while minimizing acute systemic inflammation have proven difficult. Here, using a library of R848 "bottlebrush prodrugs" (BPDs) that differ only by their R848 release kinetics, we explore how the timing of R848 exposure affects immune stimulation in vitro and in vivo...
April 21, 2023: Science Advances
#53
JOURNAL ARTICLE
Theresa M Raimondo, Kaelan Reed, Dennis Shi, Robert Langer, Daniel G Anderson
Decades of oncologic clinical use have demonstrated that cancer immunotherapy provides unprecedented therapeutic benefits. Tragically, only a minority of patients respond to existing immunotherapies. RNA lipid nanoparticles have recently emerged as modular tools for immune stimulation. Here, we discuss advancements in RNA-based cancer immunotherapies and opportunities for improvement.
April 13, 2023: Cell
#54
REVIEW
Yihai Cao, Robert Langer, Napoleone Ferrara
Angiogenesis is an essential process in normal development and in adult physiology, but can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating diseases was proposed more than 50 years ago, and the first two drugs targeting vascular endothelial growth factor (VEGF), bevacizumab and pegaptanib, were approved in 2004 for the treatment of cancer and neovascular ophthalmic diseases, respectively. Since then, nearly 20 years of clinical experience with anti-angiogenic drugs (AADs) have demonstrated the importance of this therapeutic modality for these disorders...
June 2023: Nature Reviews. Drug Discovery
#55
JOURNAL ARTICLE
Róbert Langer, János Tomcsányi, László Kiss
No abstract text is available yet for this article.
April 9, 2023: Orvosi Hetilap
#56
JOURNAL ARTICLE
Bowen Li, Rajith Singh Manan, Shun-Qing Liang, Akiva Gordon, Allen Jiang, Andrew Varley, Guangping Gao, Robert Langer, Wen Xue, Daniel Anderson
The expanding applications of nonviral genomic medicines in the lung remain restricted by delivery challenges. Here, leveraging a high-throughput platform, we synthesize and screen a combinatorial library of biodegradable ionizable lipids to build inhalable delivery vehicles for messenger RNA and CRISPR-Cas9 gene editors. Lead lipid nanoparticles are amenable for repeated intratracheal dosing and could achieve efficient gene editing in lung epithelium, providing avenues for gene therapy of congenital lung diseases...
March 30, 2023: Nature Biotechnology
#57
JOURNAL ARTICLE
Sarah Funnell, Janet Jull, Lawrence Mbuagbaw, Vivian Welch, Omar Dewidar, Xiaoqin Wang, Miranda Lesperance, Elizabeth Ghogomu, Anita Rizvi, Elie A Akl, Marc T Avey, Alba Antequera, Zulfiqar A Bhutta, Catherine Chamberlain, Peter Craig, Luis Gabriel Cuervo, Alassane Dicko, Holly Ellingwood, Cindy Feng, Damian Francis, Regina Greer-Smith, Billie-Jo Hardy, Matire Harwood, Janet Hatcher-Roberts, Tanya Horsley, Clara Juando-Prats, Mwenya Kasonde, Michelle Kennedy, Tamara Kredo, Alison Krentel, Elizabeth Kristjansson, Laurenz Langer, Julian Little, Elizabeth Loder, Olivia Magwood, Michael Johnson Mahande, G J Melendez-Torres, Ainsley Moore, Loveline Lum Niba, Stuart G Nicholls, Miriam Nguilefem Nkangu, Daeria O Lawson, Ekwaro Obuku, Patrick Okwen, Tomas Pantoja, Jennifer Petkovic, Mark Petticrew, Kevin Pottie, Tamara Rader, Jacqueline Ramke, Alison Riddle, Larissa Shamseer, Melissa Sharp, Bev Shea, Peter Tanuseputro, Peter Tugwell, Janice Tufte, Erik Von Elm, Hugh Sharma Waddington, Harry Wang, Laura Weeks, George Wells, Howard White, Charles Shey Wiysonge, Luke Wolfenden, Taryn Young
BACKGROUND: Addressing persistent and pervasive health inequities is a global moral imperative, which has been highlighted and magnified by the societal and health impacts of the COVID-19 pandemic. Observational studies can aid our understanding of the impact of health and structural oppression based on the intersection of gender, race, ethnicity, age and other factors, as they frequently collect this data. However, the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guideline, does not provide guidance related to reporting of health equity...
March 30, 2023: International Journal for Equity in Health
#58
REVIEW
Tsvetelina H Baryakova, Brett H Pogostin, Robert Langer, Kevin J McHugh
Poor medication adherence is a pervasive issue with considerable health and socioeconomic consequences. Although the underlying reasons are generally understood, traditional intervention strategies rooted in patient-centric education and empowerment have proved to be prohibitively complex and/or ineffective. Formulating a pharmaceutical in a drug delivery system (DDS) is a promising alternative that can directly mitigate many common impediments to adherence, including frequent dosing, adverse effects and a delayed onset of action...
May 2023: Nature Reviews. Drug Discovery
#59
REVIEW
Ruibo Zhong, Sepehr Talebian, Bárbara B Mendes, Gordon Wallace, Robert Langer, João Conde, Jinjun Shi
RNA-based therapeutics have shown tremendous promise in disease intervention at the genetic level, and some have been approved for clinical use, including the recent COVID-19 messenger RNA vaccines. The clinical success of RNA therapy is largely dependent on the use of chemical modification, ligand conjugation or non-viral nanoparticles to improve RNA stability and facilitate intracellular delivery. Unlike molecular-level or nanoscale approaches, macroscopic hydrogels are soft, water-swollen three-dimensional structures that possess remarkable features such as biodegradability, tunable physiochemical properties and injectability, and recently they have attracted enormous attention for use in RNA therapy...
March 20, 2023: Nature Materials
#60
JOURNAL ARTICLE
Left ventricular systolic function in subjects conceived through assisted reproductive technologies.
Franziska Sciuk, Theresa Vilsmaier, Marie Kramer, Magdalena Langer, Brenda Kolbinger, Pengzhu Li, André Jakob, Nina Rogenhofer, Robert Dalla-Pozza, Christian Thaler, Nikolaus Alexander Haas, Felix Sebastian Oberhoffer
BACKGROUND: Over the past decades, assisted reproductive technologies (ART) have gained remarkable influence in the treatment of infertility and account for more than 2 % of births in European countries nowadays. Accumulating evidence suggests ART to cause cardiovascular alterations, including left ventricular (LV) dysfunctions, within its offspring. The aim of this study was to assess LV systolic function in subjects conceived through ART in comparison to spontaneously conceived peers...
2023: Frontiers in Cardiovascular Medicine
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