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JOURNAL ARTICLE
Linnea Kristenson, Chiara Badami, Angelica Ljungberg, Erna Islamagic, Yarong Tian, Guojiang Xie, Brwa Ali Hussein, Silvia Pesce, Ka-Wei Tang, Fredrik B Thorén
Natural killer (NK) cell immunotherapy has gained attention as a promising strategy for treatment of various malignancies. In this study, we used a genome-wide CRISPR screen to identify genes that provide protection or susceptibility to NK cell cytotoxicity. The screen confirmed the role of several genes in NK cell regulation, such as genes involved in interferon-γ signaling and antigen presentation, as well as genes encoding the NK cell receptor ligands B7-H6 and CD58. Notably, the gene TMEM30A , encoding CDC50A-beta-subunit of the flippase shuttling phospholipids in the plasma membrane, emerged as crucial for NK cell killing...
April 9, 2024: Proceedings of the National Academy of Sciences of the United States of America
#22
JOURNAL ARTICLE
A Y Khairul, T C Kannan, F P Erna
INTRODUCTION: The prevalence of children with disabilities (CWD) is increasing. CWD requires exceptional long-term attention, which often falls on the caregivers. Caring for a CWD affects caregivers in multiple ways, such as physical, social, personal, and financial aspects. Most of the CWD will be cared in Community-Based Rehabilitation (CBR) centres where the caregivers have to play a crucial role as they become partners in the respective service delivery. However, there is still insufficient information on the impact (strain) of a disabled child on the caregivers in the CBR centre in the Kudat division of Sabah, Malaysia specifically...
March 2024: Medical Journal of Malaysia
#23
REVIEW
Ankit Patel, Ashutosh Dharap
Noncoding DNA undergoes widespread context-dependent transcription to produce noncoding RNAs. In recent decades, tremendous advances in genomics and transcriptomics have revealed important regulatory roles for noncoding DNA elements and the RNAs that they produce. Enhancers are one such element that are well-established drivers of gene expression changes in response to a variety of factors such as external stimuli, cellular responses, developmental cues, and disease states. They are known to act at long distances, interact with multiple target gene loci simultaneously, synergize with other enhancers, and associate with dynamic chromatin architectures to form a complex regulatory network...
March 28, 2024: Neuromolecular Medicine
#24
REVIEW
Erna Mitaishvili, Hanna Feinsod, Zachary David, Jessica Shpigel, Chelsea Fernandez, Moira Sauane, Columba de la Parra
Altered metabolism represents a fundamental difference between cancer cells and normal cells. Cancer cells have a unique ability to reprogram their metabolism by deviating their reliance from primarily oxidative phosphorylation (OXPHOS) to glycolysis, in order to support their survival. This metabolic phenotype is referred to as the "Warburg effect" and is associated with an increase in glucose uptake, and a diversion of glycolytic intermediates to alternative pathways that support anabolic processes. These processes include synthesis of nucleic acids, lipids, and proteins, necessary for the rapidly dividing cancer cells, sustaining their growth, proliferation, and capacity for successful metastasis...
March 13, 2024: Frontiers in Bioscience (Landmark Edition)
#25
REVIEW
Marco Antônio Campos, Guilherme de Pádua Zolini, Erna Geessien Kroon
Herpes simplex virus 1 (HSV-1) or simplexvirus humanalpha 1 is a neurotropic virus that is responsible for orofacial infections in humans. More than 70% of the world's population may have seropositivity for HSV-1, and this virus is a leading cause of sporadic lethal encephalitis in humans. The role of toll-like receptors (TLRs) in defending against HSV-1 infection has been explored, including the consequences of lacking these receptors or other proteins in the TLR pathway. Cell and mouse models have been used to study the importance of these receptors in combating HSV-1, how they relate to the innate immune response, and how they participate in the orchestration of the adaptive immune response...
March 14, 2024: Frontiers in Bioscience (Landmark Edition)
#26
Maria Boge Lauvsnes, Henrik Zetterberg, Kaj Blennow, Jan Terje Kvaløy, Anne Bolette Tjensvoll, Stian Maroni, Mona K Beyer, Ole Jacob Greve, Ingeborg Kvivik, Guido Alves, Lasse Gunnar Gøransson, Erna Harboe, Shunsei Hirohata, Roald Omdal
No abstract text is available yet for this article.
March 23, 2024: Journal of Neurology
#27
JOURNAL ARTICLE
Charles-Edouard Decorads, Aurélien Lambert, Véronique Roch, Laetitia Imbert, Mathieu Perrin, Marine Claudin, Matthieu Doyen, Quentin Citerne, Zohra Lamiral, Didier Peiffert, Catherine Henneton, Pierre-Yves Marie
BACKGROUND: The outcome of breast cancer (BrCa) women monitored by low-dose equilibrium radionuclide angiography (ERNA) remains challenging to predict. AIM: This study aims to determine whether heart rate (HR)/blood pressure (BP) ratio-based indexes, previously confirmed to predict outcomes of various diseases, also predict BrCa-therapy-related cardiotoxicity and survival. METHODS: Predictors of cardiotoxicity and survival were determined among pre-therapy variables, including shock index ([SI HR/systolic BP) and age-adjusted SI (ASI), in a female BrCa cohort with normal baseline ERNA-left ventricular ejection fraction (LVEF)...
March 18, 2024: Journal of Nuclear Cardiology
#28
JOURNAL ARTICLE
Toshiaki S Jo
Environmental RNA (eRNA) analysis is conventionally expected to infer physiological information about organisms within their ecosystems, whereas environmental DNA (eDNA) analysis only infers their presence and abundance. Despite the promise of eRNA application, basic research on eRNA characteristics and dynamics is limited. The present study conducted aquarium experiments using zebrafish (Danio rerio) to estimate the particle size distribution (PSD) of eRNA in order to better understand the persistence state of eRNA particles...
March 19, 2024: Die Naturwissenschaften
#29
JOURNAL ARTICLE
Robert M Hechler, Melania E Cristescu
The analyses of environmental DNA (eDNA) and environmental RNA (eRNA) released by organisms into their surrounding environment (water, soil and air) have emerged as powerful tools for monitoring biodiversity. While eDNA has been widely adopted for the non-invasive detection of species and characterization of community composition, the utilization of eRNA is still in its infancy. Due to its functional nature, eRNA holds intriguing potential for biodiversity monitoring offering new avenues of research beyond species detection...
March 19, 2024: Molecular Ecology Resources
#30
JOURNAL ARTICLE
Toshiaki S Jo, Nao Matsuda, Takaya Hirohara, Hiroki Yamanaka
Environmental DNA and RNA (eDNA and eRNA; collectively eNA) analyses have the potential for non-invasive and cost-efficient biomonitoring compared with traditional capture-based surveys. Although various types of eNA particles, including not only mitochondrial eDNA but also nuclear eDNA and their transcripts, are present in the water, performances of eNA detection and quantification have not yet been evaluated sufficiently across multiple mitochondrial and nuclear genes. We conducted a tank experiment with ayu (Plecoglossus altivelis) to compare the detection sensitivity, yields per water sample, and quantification variability between replicates of each type of eNAs...
March 16, 2024: Environmental Monitoring and Assessment
#31
JOURNAL ARTICLE
Kim C van Teunenbroek, Renée L Mulder, Inge M L Ahout, Karen G C B Bindels-de Heus, Catharina M Delsman-van Gelder, Annemie F S Galimont-Collen, Marinka A R de Groot, Katja M J Heitink-Polle, Jeffry Looijestijn, Maarten O Mensink, Selma Mulder, Jolanda H Schieving, Antoinette Y N Schouten-van Meeteren, Johannes M A Verheijden, Hester Rippen, Brigitt C M Borggreve, Leontien C M Kremer, A A Eduard Verhagen, Erna M C Michiels
BACKGROUND: Children with life-threatening and life-limiting conditions can experience high levels of suffering due to multiple distressing symptoms that result in poor quality of life and increase risk of long-term distress in their family members. High quality symptom treatment is needed for all these children and their families, even more so at the end-of-life. In this paper, we provide evidence-based recommendations for symptom treatment in paediatric palliative patients to optimize care...
March 13, 2024: BMC Palliative Care
#32
JOURNAL ARTICLE
Katrin Y Fridgeirsdottir, Kristín A Ólafsdóttir, Anna Sigridur Islind, Timo Leppänen, Erna S Arnardottir, Jose M Saavedra
Obesity is the primary risk factor for the development of obstructive sleep apnea, and physical inactivity plays an important role. However, most studies have either only evaluated physical activity subjectively or objectively in obstructive sleep apnea. The objectives of this study were: (i) to assess the relationship between obstructive sleep apnea severity (both apnea-hypopnea index and desaturation parameters) and both objectively and subjectively measured physical activity after adjustment for anthropometry and body composition parameters; and (ii) to assess the relationship between objective and subjective physical activity parameters and whether obstructive sleep apnea severity has a modulatory effect on this relationship...
March 13, 2024: Journal of Sleep Research
#33
JOURNAL ARTICLE
Helen P A Driessen, Jan J V Busschbach, Erna J Elfrink, Carin C D van der Rijt, Gabriël M R M Paardekooper, Corine J den Hollander, Leonieke W Kranenburg
OBJECTIVES: Clear information and supportive care are necessary for oncology patients and their relatives to manage the disease (trajectory). Centres for information and support aim to address their needs by offering informal and non-medical formal services. This study evaluated whether the centres' services offered meet the needs of its visitors, and whether there is interest for these among oncology patients treated at affiliated hospitals. METHODS: In this participatory action research, interviews were conducted among visitors of two centres (Patient Information Center Oncology (PATIO) and IntermeZZo) and among patients treated at the affiliated hospitals...
March 12, 2024: BMJ Supportive & Palliative Care
#34
JOURNAL ARTICLE
Piia Karisola, Veera Nikkola, Heli Joronen, Lasse Ylianttila, Mari Grönroos, Timo Partonen, Erna Snellman, Harri Alenius
BACKGROUND: The underlying molecular mechanisms that determine the biological effects of UVB radiation exposure on human skin are still only partially comprehended. OBJECTIVES: Our goal is to examine the human skin transcriptome and related molecular mechanisms following a single exposure to UVB in the morning versus evening. METHODS: We exposed 20 volunteer females to four-fold standard erythema doses (SED4) of narrow-band UVB (309-313 nm) in the morning or evening and studied skin transcriptome 24 h after the exposure...
March 6, 2024: Journal of Photochemistry and Photobiology. B, Biology
#35
JOURNAL ARTICLE
Keisuke Katsushima, Kandarp Joshi, Menglang Yuan, Brigette Romero, Mona Batish, Stacie Stapleton, George Jallo, Elayaraja Kolanthai, Sudipta Seal, Olivier Saulnier, Michael D Taylor, Robert J Wechsler-Reya, Charles G Eberhart, Ranjan J Perera
Recent studies suggest that long non-coding RNAs (lncRNAs) contribute to medulloblastoma (MB) formation and progression. We have identified an lncRNA, lnc-HLX-2-7, as a potential therapeutic target in group 3 (G3) MBs. lnc-HLX-2-7 RNA specifically accumulates in the promoter region of HLX, a sense-overlapping gene of lnc-HLX-2-7, which activates HLX expression by recruiting multiple factors, including enhancer elements. RNA sequencing and chromatin immunoprecipitation reveal that HLX binds to and activates the promoters of several oncogenes, including TBX2, LIN9, HOXM1, and MYC...
March 8, 2024: Cell Reports
#36
JOURNAL ARTICLE
Fernanda Lie Ikari, Cristina Viriato, Fernanda Menezes França, Adriana Sacioto Marcantonio, Erna Elizabeth Bach, Cintia Badaró-Pedroso, Cláudia Maris Ferreira
Atrazine (ATZ) is the third most sold herbicide in Brazil, occupying the seventh position between most widely used pesticides. Due to its easy outflow, low reactivity and solubility, moderate adsorption to organic matter and clay, and long soil persistence, residual herbicide can be identified after long periods following application, and its usage has been prohibited in diverse countries. Amphibians are important bioindicators to assess impact of pesticide like atrazine, due to having a partial aquatic life cycle...
March 8, 2024: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
#37
JOURNAL ARTICLE
Ying Liu, Yanyong Zhao, Lin Lin, Qinghua Yang, Ling Zhang
PURPOSE: Congenital microtia is a complex maxillofacial malformation with various risk factors. This study aimed to find potential pathogenic noncoding RNAs for congenital microtia patients. METHODS: We collected 3 pairs of residual ear cartilage samples and corresponding normal ear cartilage samples from nonsyndromic congenital microtia patients for microarray experiments. The differentially expressed RNAs were screened, and enrichment analysis and correlation expression analysis were performed to elucidate the function of the differentially expressed genes (DEGs)...
March 8, 2024: Journal of Craniofacial Surgery
#38
JOURNAL ARTICLE
Per A Andersson, Irina Vartanova, Daniel Västfjäll, Gustav Tinghög, Pontus Strimling, Junhui Wu, Isabela Hazin, Charity S Akotia, Alisher Aldashev, Giulia Andrighetto, Adote Anum, Gizem Arikan, Fatemeh Bagherian, Davide Barrera, Dana Basnight-Brown, Birzhan Batkeyev, Elizaveta Berezina, Marie Björnstjerna, Paweł Boski, Inna Bovina, Bui Thi Thu Huyen, Đorđe Čekrlija, Hoon-Seok Choi, Carlos C Contreras-Ibáñez, Rui Costa-Lopes, Mícheál de Barra, Piyanjali de Zoysa, Angela R Dorrough, Nikolay Dvoryanchikov, Jan B Engelmann, Hyun Euh, Xia Fang, Susann Fiedler, Olivia A Foster-Gimbel, Márta Fülöp, Ragna B Gardarsdottir, C M Hew D Gill, Andreas Glöckner, Sylvie Graf, Ani Grigoryan, Vladimir Gritskov, Katarzyna Growiec, Peter Halama, Andree Hartanto, Tim Hopthrow, Martina Hřebíčková, Dzintra Iliško, Hirotaka Imada, Hansika Kapoor, Kerry Kawakami, Narine Khachatryan, Natalia Kharchenko, Toko Kiyonari, Michal Kohút, Lisa M Leslie, Yang Li, Norman P Li, Zhuo Li, Kadi Liik, Angela T Maitner, Bernardo Manhique, Harry Manley, Imed Medhioub, Sari Mentser, Pegah Nejat, Orlando Nipassa, Ravit Nussinson, Nneoma G Onyedire, Ike E Onyishi, Penny Panagiotopoulou, Lorena R Perez-Floriano, Minna Persson, Anna-Maija Pirttilä-Backman, Marianna Pogosyan, Jana Raver, Ricardo Borges Rodrigues, Sara Romanò, Pedro P Romero, Inari Sakki, Alvaro San Martin, Sara Sherbaji, Hiroshi Shimizu, Brent Simpson, Erna Szabo, Kosuke Takemura, Maria Luisa Mendes Teixeira, Napoj Thanomkul, Habib Tiliouine, Giovanni A Travaglino, Yannis Tsirbas, Sita Widodo, Rizqy Zein, Lina Zirganou-Kazolea, Kimmo Eriksson
When someone violates a social norm, others may think that some sanction would be appropriate. We examine how the experience of emotions like anger and disgust relate to the judged appropriateness of sanctions, in a pre-registered analysis of data from a large-scale study in 56 societies. Across the world, we find that individuals who experience anger and disgust over a norm violation are more likely to endorse confrontation, ostracism and, to a smaller extent, gossip. Moreover, we find that the experience of anger is consistently the strongest predictor of judgments of confrontation, compared to other emotions...
March 7, 2024: Scientific Reports
#39
JOURNAL ARTICLE
Lena Rettinger, Erna Schönthaler, Andrea Kerschbaumer, Carina Hauser, Carissa Klupper, Lea Aichinger, Franz Werner
BACKGROUND: The acquisition of handwriting skills is essential for a child's academic success, self-confidence, and general school performance. Nevertheless, an estimated 5% to 27% of children face handwriting challenges, where the ability to modulate pressure on the pencil and lead on the paper is a key motor component. OBJECTIVE: We aimed to investigate the experience with and usability of the SensoGrip system, a pressure-measuring pen system with personalized real-time feedback about pressure modulation, in a clinical setting with children and occupational therapists (OTs)...
March 7, 2024: JMIR Rehabilitation and Assistive Technologies
#40
JOURNAL ARTICLE
Nanda S Monica, Amira P Tarigan, Andika Pradana, Erna Mutiara, Pandiaman Pandia, Bintang Ym Sinaga, Benny Sihombing, Ella Rhinsilva, Zulkarnain Zulkarnain, Aditya S Listyoko
Lack of physical exercise and inadequate nutritional intake in chronic obstructive pulmonary disease (COPD) patients could lead to low muscle mass and function, which causes reduced respiratory function, increased incidence of exacerbations, exercise intolerance, increased visits to health facilities, and low health status. Therefore, physical exercise and good nutritional intake are the main foundations of a comprehensive pulmonary rehabilitation program for COPD patients. The aim of the study was to determine the effect of chicken egg white supplementation on dyspnea degree and the incidence of exacerbations in stable COPD patients who perform physical exercise independently at home...
December 2023: Narra J
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