Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Sean M McCarty, Martin C Clasby, Jonathan Z Sexton
The progression of type II diabetes (T2D) is characterized by a complex and highly variable loss of beta-cell mass, resulting in impaired insulin secretion. Many T2D drug discovery efforts aimed at discovering molecules that can protect or restore beta-cell mass and function have been developed using limited beta-cell lines and primary rodent/human pancreatic islets. Various high-throughput screening methods have been used in the context of drug discovery, including luciferase-based reporter assays, glucose-stimulated insulin secretion, and high-content screening...
March 25, 2024: Assay and Drug Development Technologies
#2
JOURNAL ARTICLE
Rebecca F Slykerman, Betony E Clasby, Jimmy Chong, Kathryn Edward, Barry J Milne, Helen Temperton, Hiran Thabrew, Nicholas Bowden
BACKGROUND: Population-level administrative data provides a cost-effective means of monitoring health outcomes and service needs of clinical populations. This study aimed to present a method for case identification of non-traumatic brain injury in population-level data and to examine the association with sociodemographic factors. METHODS: An estimated resident population of youth aged 0-24 years was constructed using population-level datasets within the New Zealand Integrated Data Infrastructure...
March 2, 2024: BMC Neurology
#3
JOURNAL ARTICLE
Sotirios Papamatthaiou, James Boxall-Clasby, Edward J A Douglas, Pawel Jajesniak, Hadrien Peyret, June Mercer-Chalmers, Varun K S Kumar, George P Lomonossoff, Julien Reboud, Maisem Laabei, Jonathan M Cooper, Barbara Kasprzyk-Hordern, Despina Moschou
The recent COVID-19 outbreak highlighted the need for lab-on-chip diagnostic technology fit for real-life deployment in the field. Existing bottlenecks in multistep analytical microsystem integration and upscalable, standardized fabrication techniques delayed the large-scale deployment of lab-on-chip solutions during the outbreak, throughout a global diagnostic test shortage. This study presents a technology that has the potential to address these issues by redeploying and repurposing the ubiquitous printed circuit board (PCB) technology and manufacturing infrastructure...
September 22, 2023: Lab on a Chip
#4
JOURNAL ARTICLE
Sean M McCarty, Martin C Clasby, Jonathan Z Sexton
Diabetes poses a global health crisis affecting individuals across age groups and backgrounds, with a prevalence estimate of 700 million people worldwide by 2045. Current therapeutic strategies primarily rely on insulin therapy or hypoglycemic agents, which fail to address the root cause of the disease - the loss of pancreatic insulin-producing beta-cells. Therefore, bioassays that recapitulate intact islets are needed to enable drug discovery for beta-cell replenishment, protection from beta-cell loss, and islet-cell interactions...
July 30, 2023: SLAS Discovery
#5
JOURNAL ARTICLE
Francesca Anns, Stephanie D'Souza, Conrad MacCormick, Brigit Mirfin-Veitch, Betony Clasby, Nathan Hughes, Warren Forster, Eden Tuisaula, Nicholas Bowden
OBJECTIVE: To examine criminal justice system (CJS) interactions and pathways through the justice system for young adults with ADHD compared to young adults without ADHD. METHOD: Nationwide 3-year birth cohort study using linked health and CJS data. Cox proportional hazards models were employed to examine associations between ADHD and police proceedings, court charges, court convictions, and incarcerations. RESULTS: Young adults with ADHD were significantly more likely to interact with the CJS including police proceedings (hazard ratio [HR], 2...
May 30, 2023: Journal of Attention Disorders
#6
REVIEW
Betony Clasby, Nathan Hughes, Elizabeth Clasby, Cathy Catroppa
BACKGROUND: Childhood traumatic brain injury (TBI) can result in impairments in learning, cognition, and behaviour; all of which can adversely influence educational outcomes. Schools can play a crucial role in rehabilitation, therefore it is important that evidence-based supports are available in these settings. OBJECTIVE: The aim of this systematic review was to evaluate the effectiveness of school-based supports and interventions available following childhood TBI...
May 13, 2023: NeuroRehabilitation
#7
JOURNAL ARTICLE
April L Solon, Taylor M Zaniewski, Patrick O'Brien, Martin Clasby, William O Hancock, Ryoma Ohi
Mitosis is the cellular process that ensures accurate segregation of the cell's genetic material into two daughter cells. Mitosis is often deregulated in cancer, thus drugs that target mitosis-specific proteins represent attractive targets for anticancer therapy. Numerous inhibitors have been developed against kinesin-5 Eg5, a kinesin essential for bipolar spindle assembly. Unfortunately, Eg5 inhibitors (K5Is) have been largely ineffective in the clinic, possibly due to the activity of a second kinesin, KIF15, that can suppress the cytotoxic effect of K5Is by driving spindle assembly through an Eg5-independent pathway...
October 6, 2022: Molecular Biology of the Cell
#8
REVIEW
Andrew I R Maas, David K Menon, Geoffrey T Manley, Mathew Abrams, Cecilia Åkerlund, Nada Andelic, Marcel Aries, Tom Bashford, Michael J Bell, Yelena G Bodien, Benjamin L Brett, András Büki, Randall M Chesnut, Giuseppe Citerio, David Clark, Betony Clasby, D Jamie Cooper, Endre Czeiter, Marek Czosnyka, Kristen Dams-O'Connor, Véronique De Keyser, Ramon Diaz-Arrastia, Ari Ercole, Thomas A van Essen, Éanna Falvey, Adam R Ferguson, Anthony Figaji, Melinda Fitzgerald, Brandon Foreman, Dashiell Gantner, Guoyi Gao, Joseph Giacino, Benjamin Gravesteijn, Fabian Guiza, Deepak Gupta, Mark Gurnell, Juanita A Haagsma, Flora M Hammond, Gregory Hawryluk, Peter Hutchinson, Mathieu van der Jagt, Sonia Jain, Swati Jain, Ji-Yao Jiang, Hope Kent, Angelos Kolias, Erwin J O Kompanje, Fiona Lecky, Hester F Lingsma, Marc Maegele, Marek Majdan, Amy Markowitz, Michael McCrea, Geert Meyfroidt, Ana Mikolić, Stefania Mondello, Pratik Mukherjee, David Nelson, Lindsay D Nelson, Virginia Newcombe, David Okonkwo, Matej Orešič, Wilco Peul, Dana Pisică, Suzanne Polinder, Jennie Ponsford, Louis Puybasset, Rahul Raj, Chiara Robba, Cecilie Røe, Jonathan Rosand, Peter Schueler, David J Sharp, Peter Smielewski, Murray B Stein, Nicole von Steinbüchel, William Stewart, Ewout W Steyerberg, Nino Stocchetti, Nancy Temkin, Olli Tenovuo, Alice Theadom, Ilias Thomas, Abel Torres Espin, Alexis F Turgeon, Andreas Unterberg, Dominique Van Praag, Ernest van Veen, Jan Verheyden, Thijs Vande Vyvere, Kevin K W Wang, Eveline J A Wiegers, W Huw Williams, Lindsay Wilson, Stephen R Wisniewski, Alexander Younsi, John K Yue, Esther L Yuh, Frederick A Zeiler, Marina Zeldovich, Roger Zemek
Traumatic brain injury (TBI) has the highest incidence of all common neurological disorders, and poses a substantial public health burden. TBI is increasingly documented not only as an acute condition but also as a chronic disease with long-term consequences, including an increased risk of late-onset neurodegeneration. The first Lancet Neurology Commission on TBI, published in 2017, called for a concerted effort to tackle the global health problem posed by TBI. Since then, funding agencies have supported research both in high-income countries (HICs) and in low-income and middle-income countries (LMICs)...
November 2022: Lancet Neurology
#9
JOURNAL ARTICLE
Jesse W Wotring, Sean M McCarty, Khadija Shafiq, Charles J Zhang, Theophilus Nguyen, Sophia R Meyer, Reid Fursmidt, Carmen Mirabelli, Martin C Clasby, Christiane E Wobus, Matthew J O'Meara, Jonathan Z Sexton
Niclosamide, an FDA-approved oral anthelmintic drug, has broad biological activity including anticancer, antibacterial, and antiviral properties. Niclosamide has also been identified as a potent inhibitor of SARS-CoV-2 infection in vitro, generating interest in its use for the treatment or prevention of COVID-19. Unfortunately, there are several potential issues with using niclosamide for COVID-19, including low bioavailability, significant polypharmacology, high cellular toxicity, and unknown efficacy against emerging SARS-CoV-2 variants of concern...
August 9, 2022: Vaccines
#10
JOURNAL ARTICLE
Betony Clasby, Brigit Mirfin-Veitch, Rose Blackett, Sally Kedge, Esther Whitehead
Recent research has highlighted that a high prevalence of young adults who have various forms of neurodivergence come into contact with the criminal justice system. Currently, many courts are not designed to respond to neurological differences often seen in young people who engage with them. The aim of this study was to identify ways to make locality courts more accessible, engaging, and ultimately more responsive to neurodivergence. A panel of neurodivergence specialists reviewed the general district courtroom environment of a new specialised young adult list court in Aotearoa New Zealand to identify potential barriers to accessibility and to highlight areas for improvement...
June 2022: Criminal Behaviour and Mental Health: CBMH
#11
JOURNAL ARTICLE
Julian Faraway, James Boxall-Clasby, Edward J Feil, Marjorie J Gibbon, Oliver Hatfield, Barbara Kasprzyk-Hordern, Theresa Smith
Researchers around the world have demonstrated correlations between measurements of SARS-CoV-2 RNA in wastewater (WW) and case rates of COVID-19 derived from direct testing of individuals. This has raised concerns that wastewater-based epidemiology (WBE) methods might be used to quantify the spread of this and other diseases, perhaps faster than direct testing, and with less expense and intrusion. We illustrate, using data from Scotland and the USA, the issues regarding the construction of effective predictive models for disease case rates...
July 2022: Journal of Water and Health
#12
Jesse W Wotring, Sean M McCarty, Khadija Shafiq, Charles J Zhang, Theophilus Nguyen, Sophia R Meyer, Reid Fursmidt, Carmen Mirabelli, Martin C Clasby, Christiane E Wobus, Matthew J O'Meara, Jonathan Z Sexton
Niclosamide, an FDA-approved oral anthelmintic drug, has broad biological activity including anticancer, antibacterial, and antiviral properties. Niclosamide has also been identified as a potent inhibitor of SARS-CoV-2 infection in vitro , generating interest in its use for the treatment or prevention of COVID-19. Unfortunately, there are several potential issues with using niclosamide for COVID-19, including low bioavailability, significant polypharmacology, high cellular toxicity, and unknown efficacy against emerging SARS-CoV-2 variants of concern...
July 13, 2022: bioRxiv
#13
JOURNAL ARTICLE
Nicholas Bowden, Barry Milne, Richard Audas, Betony Clasby, Joanne Dacombe, Warren Forster, Jesse Kokaua, Sheree Gibb, Nathan Hughes, Conrad MacCormick, Kirsten Smiler, Barry Taylor, Brigit Mirfin-Veitch
Sensationalist headlines and highly publicised criminal cases lead many in the public to believe that people with autism are more likely to engage in criminal behaviour. However, recent studies present an unresolved debate, and indicate this may not necessarily be the case. The aims of this study were to examine the prevalence of criminal justice system interactions among young adults with and without autism, and determine whether offence types differ between these groups. We tracked a national birth cohort until their 25th birthday, detecting criminal justice system interactions from age 17 onwards...
October 2022: Autism: the International Journal of Research and Practice
#14
JOURNAL ARTICLE
Tracy B Chamblee, Lindsey J Patton, Virginia B Young, Jennifer Marusich, Cindy D Bowens, Darryl K Miles
Healthcare organizations have prioritized patient safety and quality improvement efforts to reduce central line-associated bloodstream infections (CLABSIs). Implementation of central venous catheter (CVC) insertion and maintenance bundles have significantly reduced infection rates. Nevertheless, CLABSIs continue to be a significant cause of mortality and morbidity in hospitals, and further efforts are necessary to improve CVC care practices. A hospital-wide committee at a tertiary care pediatric hospital identified gaps in our CVC maintenance practices resulting from CVC contamination events from a patient's body fluids...
October 28, 2021: British Journal of Nursing: BJN
#15
JOURNAL ARTICLE
Charles L Jayne, Teresa Andreani, Tin-Yau Chan, Mariappan V Chelliah, Martin C Clasby, Michael Dwyer, Keith A Eagen, Steve Fried, William J Greenlee, Zhuyan Guo, Brian Hawes, Alan Hruza, Richard Ingram, Kartik M Keertikar, Santhosh Neelamkavil, Paul Reichert, Yan Xia, Samuel Chackalamannil
The synthesis and structure activity relationship development of a pyrimidine series of heterocyclic Factor IXa inhibitors is described. Increased selectivity over Factor Xa inhibition was achieved through SAR expansion of the P1 element. Select compounds were evaluated in vivo to assess their plasma levels in rat.
August 1, 2020: Bioorganic & Medicinal Chemistry Letters
#16
JOURNAL ARTICLE
Stuart A Kinner, Nathan Hughes, Rohan Borschmann, Louise Southalan, Betony Clasby, Emilia Janca, Melissa Willoughby, Huw Williams
No abstract text is available yet for this article.
January 2020: Lancet Child & Adolescent Health
#17
JOURNAL ARTICLE
Betony Clasby, Matthew Bennett, Nathan Hughes, Emma Hodges, Hannah Meadham, Darren Hinder, Huw Williams, Avril Mewse
Purpose: Paediatric traumatic brain injury (TBI) can have resultant ongoing significant impairments which can impact life outcomes. The primary aim of this research was to explore whether TBI contributes to the relationship between poor educational outcomes and offending trajectories. Materials and methods: Through analysis of a dataset consisting of self-reported health, educational, and offending histories of 70 incarcerated young males, structural equation modelling was used to explore the mediation of educational outcomes and patterns in offending behaviour by chronic symptoms following TBI...
August 2020: Disability and Rehabilitation
#18
Andrea Vila, Cintia Jahan, Cynthia Rivero, Claudio Amadio, Adela Ampuero, Hugo Pagella
Exophiala dermatitidis is a dematiaceous fungus with yeast-like and hyphal growth states that may cause cutaneous and visceral infections. Recently, E. dermatitidis has been linked to central line associated blood stream infection (CLABSI), probably due to its ability to produce extracellular polysaccharides and grow as biofilm. We describe an E. dermatitidis CLASBI. The strain was identified by morphological and molecular methods. E. dermatitidis CLASBI is highly uncommon, but seems to be increasing.
June 2019: Medical Mycology Case Reports
#19
REVIEW
Community-based interventions for adolescents following traumatic brain injury: A systematic review.
Betony Clasby, Nathan Hughes, Cathy Catroppa, Elle Morrison
BACKGROUND: Chronic impairment following childhood traumatic brain injury has the potential to increase risk of negative outcomes. This highlights potential value in community-based rehabilitation programs. OBJECTIVES: To identify research studies examining existing intervention programmes available in community-based rehabilitation to adolescents following TBI to assist with the transition back into the community. METHODS: A systematic review of community-based interventions was conducted across different national contexts...
2018: NeuroRehabilitation
#20
JOURNAL ARTICLE
Francisco Velázquez, Mariappan Chelliah, Martin Clasby, Zhuyan Guo, John Howe, Randy Miller, Santhosh Neelamkavil, Unmesh Shah, Aileen Soriano, Yan Xia, Srikanth Venkatraman, Samuel Chackalamannil, Ian W Davies
A new class of hepatitis C NS3/4A inhibitors was identified by introducing a novel spirocyclic proline-P2 surrogate onto the P2-P4 macrocyclic core of MK-5172 (grazoprevir). The potency profile of new analogues showed excellent pan-genotypic activity for most compounds. The potency evaluation included the most difficult genotype 3a (EC50 values ≤10 nM) and other key genotype 1b mutants. Molecular modeling was used to design new target compounds and rationalize our results. A synthetic approach based on the Julia-Kocienski olefination and macrolactamization to assemble the P2-P4 macrocyclic core containing the novel spirocyclic proline-P2 moiety is presented as well...
December 8, 2016: ACS Medicinal Chemistry Letters
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
