Nicolò Danesin, Greta Scapinello, Dorella Del Prete, Elena Naso, Tamara Berno, Andrea Visentin, Laura Bonaldi, Annalisa Martines, Roberta Bertorelle, Fabrizio Vianello, Carmela Gurrieri, Renato Zambello, Chiara Castellani, Marny Fedrigo, Stefania Rizzo, Annalisa Angelini, Livio Trentin, Francesco Piazza
BACKGROUND: Renal injury related to Waldenström macroglobulinemia (WM) occurs in approximately 3% of patients. Kidney biopsy is crucial to discriminate between distinct histopathological entities such as glomerular (amyloidotic and non-amyloidotic), tubulo-interstitial and non-paraprotein mediated renal damage. In this context, disease characterization, management, relationship between renal, and hematological response have been poorly explored. We collected clinical, genetic and laboratory data of seven cases of biopsy-proven renal involvement by WM managed at our academic center and focused on three cases we judged paradigmatic discussing their histopathological patterns, clinical features, and therapeutic options...
April 2024: Cancer reports