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JOURNAL ARTICLE
A Dahlan, N M Dzaki, I S Adeli, N Nurhidayah
INTRODUCTION: There is a global increase in the ageing population, and Malaysia is expected to become an ageing country. As elderly individuals experience deterioration in physical and cognitive functions, they often require longterm care from caregivers. This study aims to investigate the reasons why caregivers provide care for older adults at home. MATERIALS AND METHODS: A qualitative phenomenological approach was employed, and semi-structured face-to-face interviews were conducted with 12 caregivers...
May 2024: Medical Journal of Malaysia
#42
COMPARATIVE STUDY
Andreas De Paepe, Erika Vlieghe, Nele Brusselaers, Patrick Soentjens, Caroline Theunissen, Isabel Brosius, Jeroen Grouwels, Lida Van Petersen, Hanne van Tiggelen, Walter Verbrugghe, Philippe G Jorens, Thérèse Lapperre, Karen Peeters, Griet Vermeulen, Sabrina H van Ierssel
PURPOSE: Few studies have compared patient characteristics, clinical management, and outcome of patients with COVID-19 between the different epidemic waves. In this study, we describe patient characteristics, treatment, and outcome of patients admitted for COVID-19 in the Antwerp University Hospital over the first three epidemic waves of 2020-2021. METHODS: Retrospective observational study of COVID-19 patients in a Belgian tertiary referral hospital. All adult patients with COVID-19, hospitalized between February 29, 2020, and June 30, 2021, were included...
May 30, 2024: Virology Journal
#43
JOURNAL ARTICLE
Chunyang Fan, Wei Wang, Zilin Yu, Jiale Wang, Wei Xu, Zhongwei Ji, Wei He, Di Hua, Wentao Wang, Linye Yao, Yongkang Deng, Dechun Geng, Xiexing Wu, Haiqing Mao
Intervertebral disc degeneration (IVDD) is the primary factor contributing to low back pain (LBP). Unlike elderly patients, many young IVDD patients usually have a history of trauma or long-term abnormal stress, which may lead to local inflammatory reaction causing by immune cells, and ultimately accelerates degeneration. Research has shown the significance of M1-type macrophages in IVDD; nevertheless, the precise mechanism and the route by which it influences the function of nucleus pulposus cell (NPC) remain unknown...
May 31, 2024: Journal of Nanobiotechnology
#44
REVIEW
Belinda De Simone, Elie Chouillard, Mauro Podda, Nikolaos Pararas, Gustavo de Carvalho Duarte, Paola Fugazzola, Arianna Birindelli, Federico Coccolini, Andrea Polistena, Maria Grazia Sibilla, Vitor Kruger, Gustavo P Fraga, Giulia Montori, Emanuele Russo, Tadeja Pintar, Luca Ansaloni, Nicola Avenia, Salomone Di Saverio, Ari Leppäniemi, Andrea Lauretta, Massimo Sartelli, Alessandro Puzziello, Paolo Carcoforo, Vanni Agnoletti, Luca Bissoni, Arda Isik, Yoram Kluger, Ernest E Moore, Oreste Marco Romeo, Fikri M Abu-Zidan, Solomon Gurmu Beka, Dieter G Weber, Edward C T H Tan, Ciro Paolillo, Yunfeng Cui, Fernando Kim, Edoardo Picetti, Isidoro Di Carlo, Adriana Toro, Gabriele Sganga, Federica Sganga, Mario Testini, Giovanna Di Meo, Andrew W Kirkpatrick, Ingo Marzi, Nicola déAngelis, Michael Denis Kelly, Imtiaz Wani, Boris Sakakushev, Miklosh Bala, Luigi Bonavina, Joseph M Galante, Vishal G Shelat, Lorenzo Cobianchi, Francesca Dal Mas, Manos Pikoulis, Dimitrios Damaskos, Raul Coimbra, Jugdeep Dhesi, Melissa Red Hoffman, Philip F Stahel, Ronald V Maier, Andrey Litvin, Rifat Latifi, Walter L Biffl, Fausto Catena
BACKGROUND: The trauma mortality rate is higher in the elderly compared with younger patients. Ageing is associated with physiological changes in multiple systems and correlated with frailty. Frailty is a risk factor for mortality in elderly trauma patients. We aim to provide evidence-based guidelines for the management of geriatric trauma patients to improve it and reduce futile procedures. METHODS: Six working groups of expert acute care and trauma surgeons reviewed extensively the literature according to the topic and the PICO question assigned...
May 31, 2024: World Journal of Emergency Surgery: WJES
#45
JOURNAL ARTICLE
Afrah A Ali
BACKGROUND: Emergency department (ED) boarding of psychiatric patients is a national issue that continues to worsen at a disturbing rate. Implementing strategies in the ED to provide continuous care for patients can help secure patient safety. OBJECTIVE: The objective of this review is to discuss the boarding of psychiatric patients and its implications. It will focus on executing best clinical practices in managing boarding psychiatric patients in the ED. It will not focus on the treatment of substance use disorders...
March 14, 2024: Journal of Emergency Medicine
#46
JOURNAL ARTICLE
Freya Harding, David Howlett, Muhannad Al-Hashim
An elderly male with type 2 diabetes presented with a 2-month history of otalgia and severe headaches. He was diagnosed with malignant otitis externa (MOE) and was commenced on empirical treatment with oral ciprofloxacin. Pseudomonas is the most common cause of MOE. A baseline CT scan was undertaken that demonstrated skull base osteomyelitis (SBO) due to findings of bone erosion at the mastoid tip and an infiltrating soft tissue mass eroding the clivus. Eight weeks later, he returned with worsening and bilateral symptoms of otitis externa, hearing loss, temporomandibular pain and dysfunction...
May 30, 2024: British Journal of Hospital Medicine
#47
EDITORIAL
Anne Hendry, Ruth Law
Many providers aspire to scale up proactive care that prevents escalation of health and care needs, delays onset of disability, and reduces demand for emergency department attendance or admission to hospital or care home. NHS England offers guidance on personalised and coordinated multi-professional support and interventions for people with moderate or severe frailty. This article reflects on the growing international evidence for an integrated proactive approach for older people with frailty and why investing in high-quality, joined-up care for older people across the whole system improves outcomes for people, reduces demand for services, increases system resilience, and delivers economic and societal benefits...
May 30, 2024: British Journal of Hospital Medicine
#48
JOURNAL ARTICLE
Jui Athavale, Nandini Sethuraman, Ram Gopalakrishnan
Rhodococcus hoagii is a gram positive actinomycete found in horses and cattle. Humans can be infected by ingestion or inhalation through contaminated food or soil. The organism usually infects immunosuppressed hosts with pneumonia being the common presentation. We present a case of an 89 years old, apparently immunocompetent host presenting with fever, encephalopathy and arthritis who grew Rhodococcus hoagii in blood and synovial fluid, The patient responded well to a combination of vancomycin, azithromycin and imipenem-cilastatin...
May 28, 2024: Indian Journal of Medical Microbiology
#49
JOURNAL ARTICLE
Rachel Gefen, Sameh Hany Emile, Zoe Garoufalia, Nir Horesh, Justin Dourado, Steven D Wexner
BACKGROUND: Treatment of elderly cancer patients is challenging as they can be over-treated with respect to frailty or under-treated due to advanced age. Maintaining a good quality of life is essential for this population. This study aimed to assess the difference in overall survival and short-term outcomes according to extent of rectal cancer resection in patients aged ≥80 years. METHODS: In this retrospective cohort study, very elderly patients with stage I-III rectal cancer aged ≥80 years were identified from the National Cancer Database (2004-2019)...
May 28, 2024: Journal of Gastrointestinal Surgery
#50
JOURNAL ARTICLE
Seung Hye Chu, Eun Hee Park, Haekyung Lee, Yu Ah Hong, Woo Yeong Park, Jang-Hee Cho, In O Sun, Won Min Hwang, Soon Hyo Kwon, Jin Seok Jeon, Hyunjin Noh, Kyung Don Yoo, Hyoungnae Kim
BACKGROUND: The association between high-density lipoprotein (HDL) cholesterol levels and mortality in elderly patients undergoing hemodialysis is not well established. Thus, this study investigated HDL levels and mortality in elderly Korean patients undergoing hemodialysis. METHODS: We recruited 1860 incident hemodialysis patients aged > 70 years from a retrospective cohort of the Korean Society of Geriatric Nephrology. The primary outcome measure was the all-cause mortality...
May 28, 2024: Journal of Renal Nutrition
#51
JOURNAL ARTICLE
Brandon E Lung, Matthew Kim, Kylie Callan, Maddison McLellan, Edward D Wang, William McMaster, Steven Yang, David H So
Dehydration is an overlooked modifiable risk factor that should be optimized prior to elective total hip arthroplasty (THA) to reduce postoperative complications and inpatient costs. All primary THA from 2005 - 2019 were queried from the National Surgical Quality Improvement Program database, and patients were compared based on dehydration status: blood urea nitrogen (BUN): creatinine ratio (Cr) (BUN/Cr) < 20 (nondehydrated), 20 ≤ BUN/Cr ≤ 25 (moderately dehydrated), 25 < BUN/Cr (severely dehydrated)...
2024: Journal of Surgical Orthopaedic Advances
#52
JOURNAL ARTICLE
Hee-Sun Kim, Jinhee Kim, Ji-Ah Kim
PURPOSE: The aim of this study was to investigate the mediating effects of health literacy on the relationship between frailty and health-related quality of life (HRQOL) among community-dwelling older adults. METHODS: This study used the Korean Frailty and Aging Cohort Database (KFACD) for secondary data analysis. We selected data from 1,631 people without missing main variable values for analysis. Frailty was determined based on the modified Fried's phenotype [MFP], and HRQOL was measured using the Korean version of the 5-level EuroQol questionnaire (EQ-5D-5L)...
2024: PloS One
#53
JOURNAL ARTICLE
Millan Alexander AbiNader, Andrew G Rundle, Yoosun Park, Alexander X Lo
Violence in the home, including partner violence, child abuse, and elder abuse, is pervasive in the United States. An informatics approach allowing automated analysis of administrative data to identify domestic assaults and release timely and localized data would assist preventionists to identify geographic and demographic populations of need and design tailored interventions. This study examines the use of an established national dataset, the NEMSIS 2019, as a potential annual automated data source for domestic assault surveillance...
May 30, 2024: Prevention Science: the Official Journal of the Society for Prevention Research
#54
JOURNAL ARTICLE
Changjun Chen, Qingwei Ma, Lei Zhang
No abstract text is available yet for this article.
May 29, 2024: International Journal of Surgery
#55
JOURNAL ARTICLE
Raphael Lotan, Oded Hershkovich
INTRODUCTION: CVFs are common, with several classification systems available. We have encountered osteoporotic vertebral fractures (OVFs) with PDF, a never-described fracture pattern.This study evaluates this unique fracture's characteristics. METHODS: Retrospective study of surgically treated OVFs during 2016 to 2020. RESULTS: Of 105 patients, 85 had classifiable OVFs and 20 had uni-PDF (n = 10, 9.5%) or bi-PDF (n = 10, 9.5%). Both cohorts mainly had single vertebral fractures and upper end plate involvement with cleft sign found in 30% of PDFs versus 15...
June 1, 2024: Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews
#56
REVIEW
Donald P Tashkin, Igor Barjaktarevic, Julio Gomez-Seco, Naser Hassan Behbehani, Arkady Koltun, Urooj Alam Siddiqui
Background: Chronic obstructive pulmonary disease (COPD) is a preventable, progressive disease and the third leading cause of death worldwide. The epidemiological data of COPD from Gulf countries are very limited, as it remains underdiagnosed and underestimated. Risk factors for COPD include tobacco cigarette smoking, water pipe smoking (Shisha), exposure to air pollutants, occupational dusts, fumes, and chemicals. Inadequate treatment of COPD leads to worsening of disease. The 2024 GOLD guidelines recommend use of inhaled bronchodilators, corticosteroids, and adjunct therapies for treatment and management of COPD patients based on an individual assessment of the severity of symptoms and risk of exacerbations...
May 29, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
#57
JOURNAL ARTICLE
Anand Krishnan, Mahasweta Dubey, Rakesh Kumar, Harshal R Salve, Ashish Datt Upadhyay, Vivek Gupta, Sumit Malhotra, Ravneet Kaur, Baridalyne Nongkynrih, Mohan Bairwa
BACKGROUND: Different statistical approaches for estimating excess deaths due to coronavirus disease 2019 (COVID-19) pandemic have led to varying estimates. In this study, we developed and validated a covariate-based model (CBM) with imputation for prediction of district-level excess deaths in India. METHODS: We used data extracted from deaths registered under the Civil Registration System for 2015-19 for 684 of 713 districts in India to estimate expected deaths for 2020 through a negative binomial regression model (NBRM) and to calculate excess observed deaths...
May 31, 2024: Journal of Global Health
#58
JOURNAL ARTICLE
W Wignadasan, A Najefi, M Dewhurst, M A Fazal
BACKGROUND: Hemiarthroplasty (HA) is a common form of treatment for displaced neck of femur fractures. There is ongoing debate as to whether cemented or uncemented HA is a more superior treatment modality. The aim of this study was to compare the outcomes between patients that underwent cemented HA to uncemented HA. Secondarily, we analysed the costs associated of each treatment option. METHODS: This was a retrospective study conducted at a busy district general hospital...
June 2024: Indian Journal of Orthopaedics
#59
MULTICENTER STUDY
Ebru Damadoğlu, Özge Öztürk Aktaş, Bilun Gemicioğlu, Nafiye Yilmaz, Fulşen Bozkuş, Vehbi Ayhan, Ayse Füsun Kalpaklioğlu, Ferda Öner Erkekol, Yavuz Havlucu, Fuat Erel, Ömür Aydin, Aydanur Ekici, Ayşe Baççioğlu, Serap Argun Bariş, Gözde Köycü Buhari, Berrin Ceyhan, Özlem Göksel, Mehmet Köse, Adile Berna Dursun, Füsun Yildiz, Arzu Yorgancioğlu, Sacide Rana Işik, Dane Ediger, İpek Kıvılcım Oğuzülgen, Ahmet Uğur Demir, Gül Karakaya, Ali Fuat Kalyoncu
BACKGROUND/AIM: Characteristics of asthma in the elderly population is not well-known. The aim of the present study was to evaluate asthma in the elderly population, to compare disease characteristics between patients diagnosed <60 (aged asthma) and ≥60 (elderly asthma) years of age. MATERIALS AND METHODS: The study was a prospective, multicenter, cross-sectional type. A questionnaire was filled out to patients 60 years of age and over, that have been followed for asthma for at least 3 months...
2024: Turkish Journal of Medical Sciences
#60
REVIEW
Juan-Manuel Sancho, Marc Sorigué, Eva Rubio-Azpeitia
INTRODUCTION: Mantle cell lymphoma (MCL) is an incurable disease with an aggressive clinical course, and most patients eventually relapse after chemotherapy. Targeted therapies developed for relapsed/refractory MCL have been approved based on clinical trial data. However, real-world setting data are scarce and scattered. AREAS COVERED: This systematic review aimed to collect, synthesize, and describe the characteristics and treatment outcomes of patients with relapsed/refractory MCL after receiving a second or subsequent line of therapy in the real-world setting...
2024: Journal of Blood Medicine
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