Sucheta Mondal, Subhajit Chakraborty, Subhankar Khanra, Santana Chakraborty, Shrestha Pal, Paula Brandão, Nanda D Paul
The synthesis, characterization, and catalytic application of a new phosphine-free, well-defined, water-soluble, and air-stable Mn(II)-catalyst [Mn(L)(H2 O)2 Cl](Cl) ([ 1 ]Cl) featuring a 1,10-phenanthroline based tridentate pincer ligand, 2-(1 H -pyrazol-1-yl)-1,10-phenanthroline ( L ), in dehydrogenative functionalization of alcohols to various N -heterocycles such as quinazolin-4(3 H )-ones, quinolines, and quinoxalines are reported here. A wide array of multisubstituted quinazolin-4(3 H )-ones were prepared in water under air following two pathways via the dehydrogenative coupling of alcohols with 2-aminobenzamides and 2-aminobenzonitriles, respectively...
March 30, 2024: Journal of Organic Chemistry