Alexandre Loupy, Valentin Goutaudier, Alessia Giarraputo, Fariza Mezine, Erwan Morgand, Blaise Robin, Karen Khalil, Sapna Mehta, Brendan Keating, Amy Dandro, Anaïs Certain, Pierre-Louis Tharaux, Navneet Narula, Renaud Tissier, Sébastien Giraud, Thierry Hauet, Harvey I Pass, Aurélie Sannier, Ming Wu, Adam Griesemer, David Ayares, Vasishta Tatapudi, Jeffrey Stern, Carmen Lefaucheur, Patrick Bruneval, Massimo Mangiola, Robert A Montgomery
BACKGROUND: Cross-species immunological incompatibilities have hampered pig-to-human xenotransplantation, but porcine genome engineering recently enabled the first successful experiments. However, little is known about the immune response after the transplantation of pig kidneys to human recipients. We aimed to precisely characterise the early immune responses to the xenotransplantation using a multimodal deep phenotyping approach. METHODS: We did a complete phenotyping of two pig kidney xenografts transplanted to decedent humans...
September 30, 2023: Lancet