Kore Schlottau, Friederike Feldmann, Patrick W Hanley, Jamie Lovaglio, Tsing-Lee Tang-Huau, Kimberly Meade-White, Julie Callison, Brandi N Williamson, Rebecca Rosenke, Dan Long, Claudia Wylezich, Dirk Höper, Christiane Herden, Dana Scott, Donata Hoffmann, Greg Saturday, Martin Beer, Heinz Feldmann
Until recently, it was assumed that members of the family Bornaviridae could not induce severe disease in humans. Today, however, Borna disease virus 1 (BoDV-1), as well as the more recently emerged variegated squirrel bornavirus 1 (VSBV-1), are known as causative agents of lethal encephalitis in humans. In order to establish animal models reflecting the pathogenesis in humans and for countermeasure efficacy testing, we infected twelve rhesus macaques ( Macaca mulatta) either with VSBV-1 or with BoDV-1. For each virus, three monkeys each were inoculated with 2 × 104 focus forming units by the intracerebral route or by multiple peripheral routes (intranasal, conjunctival, intramuscular, and subcutaneous; same dose in total)...
July 2022: PNAS Nexus