diagnostic cytopathology

E Hewer
BACKGROUND: Cytology has a key role in the step-wise diagnostic approach to pancreatic mass lesions. Brush cytology and ultrasound-guided endoscopic fine-needle aspiration provide specimens for diagnosis prior to surgical or conservative therapy. The diagnostic system of the Papanicolaou Society of Cytopathology provides a conceptual framework for reporting these specimens. Cystic lesions represent a particular challenge in pancreatic cytology, as in many instances a purely morphological approach will not result in an adequate diagnostic interpretation...
November 8, 2019: Der Pathologe
William B Inabnet, Fausto Palazzo, Julie Ann Sosa, Joshua Kriger, Sebastian Aspinall, Marcin Barczynski, Gerard Doherty, Maurizio Iacobone, Erik Nordenstrom, David Scott-Coombes, Goran Wallin, Lauren Williams, Rachel Bray, Anders Bergenfelz
BACKGROUND: The Bethesda system for cytopathology (TBSRTC) is a 6-tier diagnostic framework developed to standardize thyroid cytopathology reporting. The aim of this study was to determine the risk of malignancy (ROM) for each Bethesda category. METHODS: Thyroidectomy-related data from 314 facilities in 22 countries were entered into the following outcome registries: CESQIP (North America), Eurocrine (Europe), SQRTPA (Sweden) and UKRETS (UK). Demographic, cytological, pathologic and extent of surgery data were mapped into one dataset and analyzed...
November 5, 2019: World Journal of Surgery
J M Guerra, N C C A Fernandes, R A Réssio, J A Magno, L M Kimura, J E de R Barbosa, D M B Bertollo, H H Taniguchi, R M Hiramoto, G Motoie, J E Tolezano, B Cogliati
The identification of the parasite in cytological smears of lymph node aspirates is a widely applied technique for the direct diagnosis of Leishmania spp. infection, especially in endemic areas. Although very specific, this method has limited sensitivity, and improving the technique would be highly desirable. This study aimed to evaluate the efficacy of conventional smear cytology (SC), liquid-based cytology (LBC), cell block (CB) stained with haematoxylin and eosin (HE) and immunocytochemistry (ICC), and formalin-fixed paraffin wax-embedded tissue immunohistochemistry (FFPE-IHC) compared with serology and polymerase chain reaction for the diagnosis of canine visceral leishmaniosis (CVL) in lymphoid tissue...
October 2019: Journal of Comparative Pathology
Qiong Wu, Yi Li, Yilun Liu, Jian Shen, Yan Wang, Xiaolei Yi, Bing Hu
PURPOSE: The aim of this study was to evaluate the diagnostic value of conventional sonography and ultrasound elastography for thyroid nodules of each Bethesda category and to analyze their potential role in the corresponding management decision. METHODS: This retrospective study included 557 thyroid nodules diagnosed by conventional ultrasound (US) and real-time ultrasound elastography (RTE) before fine-needle aspiration (FNA) from 458 patients. The US, RTE, and cytological results were collected and analyzed according to different Bethesda categories...
October 30, 2019: Clinical Hemorheology and Microcirculation
Barbara A Crothers, Ashish Chandra
INTRODUCTION: The International System for the Reporting of Serous Fluid Cytopathology was initiated to provide a common language for cytopathology reports on body fluids. MATERIALS AND METHODS: The International Academy of Cytology and the American Society of Cytopathology collaborated to provide evidence-based and expert-driven terminology for reporting serous fluids. Lead editors were selected and expert authors invited to form working groups for the diagnostic categories and special sections...
September 28, 2019: Journal of the American Society of Cytopathology
Esther Diana Rossi, Adebowale J Adeniran, William C Faquin
Fine-needle aspiration (FNA) is among the first diagnostic tools used in the evaluation of thyroid nodules. It has the ability to triage patients with benign and malignant lesions, thus defining the optimum clinical and/or surgical management. The Bethesda System for Reporting Thyroid Cytopathology has found worldwide acceptance. Thyroid FNA offers high positive predictive value (97%-99%), with sensitivities and specificities of 65% to 99% and 72% to 100%, respectively. Nonetheless, many potential diagnostic pitfalls exist that can lead to false-positive and/or false-negative results...
December 2019: Surgical Pathology Clinics
Jialiang Liu, Meng Xiao, Yan'an Wang
The treatment outcomes for oral sarcomatoid squamous cell carcinoma (OSSCC) are far from satisfactory in our hospital. The aim of this study was to retrospectively summarize the OSSCC cases admitted to our department. From 2003 to 2017, 14 patients were hospitalized and diagnosed with OSSCC. We summarized and analysed the medical histories, diagnostic examinations, treatment strategies, and clinical outcomes of the involved cases. Of the 14 cases, 8 were located in the gingiva. The imageological diagnosis identified the existence of a mass with an infiltrative morphology pre-operatively...
October 23, 2019: Histology and Histopathology
Shiga Rappai Chirayath, Praveen V Pavithran, Nithya Abraham, Vasantha Nair, Nisha Bhavani, Harish Kumar, Usha V Menon, Arun S Menon
Introduction: Atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has emerged as the most controversial category because of its heterogeneity and inconsistent reporting. There is a definite paucity in data available from the Indian subcontinent about the outcome of nodules carrying Bethesda category III or Bethesda category IV diagnoses. Aims and Objectives: The primary objective of our study was to determine the malignancy rate in Bethesda categories III and IV nodules...
May 2019: Indian Journal of Endocrinology and Metabolism
Erkka Tommola, Satu Tommola, Sinikka Porre, Ivana Kholová
The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was introduced in 2018 following other organ specific cytopathological reporting systems and it aimed at bringing a practical, evidence-based, user-friendly classification system with characterization and management algorithms. At the Department of Pathology, Fimlab Laboratories, Tampere, Finland all salivary fine needle aspirations (FNAs) have been given cytopathological diagnoses according to the MSRSGC since January 2018. Analyses of a one-year-period (January 2018-December 2018) consisted of 183 salivary FNA samples from 138 patients with correlation to histopathology in 90 cases with surgical follow-up...
October 18, 2019: Cancers
Ritika Mukhija, Neiwete Lomi, Saumya Kumar, Seema Sen
We report a case of a man aged 35 years who presented with the chief complaint of painless diminution of vision in the right eye for 4 months. Examination revealed a large inferior retinochoroidal mass along with retinal detachment. An anterior choroidal mass with moderate internal reflectivity was seen on B-scan ocular ultrasonography and MRI and CT scan were indicative of a mitotic aetiology. Fluorodeoxyglucose-positron emission tomography scan ruled out any other systemic foci of involvement. Based on the above findings, a provisional diagnosis of amelanotic choroidal melanoma was made and he was taken up for choroidal aspiration biopsy, wherein the cytopathology report revealed hypercellularity with no identifiable pigments...
October 13, 2019: BMJ Case Reports
Hee Young Na, Ji Won Woo, Jae Hoon Moon, June Young Choi, Woo-Jin Jeong, Yeo Koon Kim, Ji-Young Choe, So Yeon Park
This study was designed to evaluate the preoperative diagnostic categories of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) using thyroid core needle biopsy (CNB) and to analyze its impact on the risk of malignancy (ROM). A total of 2687 consecutive thyroid CNBs were reviewed retrospectively and classified into six diagnostic categories using a standardized reporting system similar to the Bethesda System for Reporting Thyroid Cytopathology. Diagnostic categories of CNBs were compared with the final surgical diagnoses, and the ROM in each category was calculated both before and after excluding NIFTP from malignancy...
October 12, 2019: Endocrine Pathology
Ilaria Girolami, Liron Pantanowitz, Stefano Marletta, Matteo Brunelli, Claudia Mescoli, Alice Parisi, Valeria Barresi, Anil Parwani, Desley Neil, Aldo Scarpa, Esther Diana Rossi, Albino Eccher
Many studies have examined the diagnostic concordance of whole slide imaging (WSI) and light microscopy (LM) for surgical pathology. In cytopathology, WSI use has been more limited, mainly because of technical issues. The aim of this study was to review the literature and determine the overall diagnostic concordance of WSI and LM in cytopathology. A systematic search of PubMed, Scopus, and the Cochrane Library was performed, with data extracted from the included articles. A quality assessment of studies was performed with a modified Quality Assessment of Diagnostic Accuracy Studies 2 tool...
October 10, 2019: Cancer Cytopathology
Siba El Hussein, Samer N Khader
Primary signet ring cell carcinoma of the pancreas (PSRCCP) is an extremely rare diagnosis that has not been extensively studied in literature. Primary and metastatic neoplasms to the pancreas may exhibit cytomorphological similarities to signet ring cells, posing diagnostic challenges. In this article, we review PSRCCP and provide a study of several primary pancreatic neoplasms that may mimic the appearance of PSRCCP upon cytopathology evaluation, shedding light on the existence of this dilemma, and helping cytopathologists in navigating similar scenarios in their practice...
October 10, 2019: Diagnostic Cytopathology
Nicholas Stanzione, Tagreed Ahmed, Po Chu Fung, Diancai Cai, David Y Lu, Lauren C Sumida, M D Neda Moatamed
OBJECTIVE: The development of The Paris System (TPS) has provided a standard and reproducible system for reporting urine cytopathology. Our goal was to study the impact of TPS on the diagnostic accuracy of urine cytology since we began using it in 2016. METHODS: We performed a retrospective study of all urine cytology specimens received at our institution from January 2015 through July 2017. Cases were included in the study if they had corresponding surgical pathology follow up...
October 9, 2019: Cytopathology: Official Journal of the British Society for Clinical Cytology
Jagadish V Hosmani, Vidya K Pujari, Vijayalaxmi S Kotrashetti, Ramakant S Nayak, Deepa V Babji, Smita M Patanshetti
INTRODUCTION: A method called sediment cytology includes the investigation of smears arranged from the sediment of the biopsy specimen fixatives. The sediment from this fixative is used to prepare smears and provides a potentially rich source for cytological material. Investigation of the fixative sediment and understanding of the cytological picture with pertinent clinical and radiological information permits diagnosis in a few hours. AIM: To evaluate the diagnostic efficacy of sediment cytology and oral brush cytology compared with histopathological findings in oral leukoplakia (OL) cases...
October 8, 2019: Acta Cytologica
Jaskirat S Takhar, Thuy A Doan, John A Gonzales
PURPOSE OF REVIEW: Vitreoretinal lymphoma (VRL) is well known as a masquerade syndrome. However, delays in diagnosis are common particularly because of the small volume of tissue that is used for investigative studies. We outline the current diagnostic tests available to clinicians and provide a glimpse of possible future novel diagnostics. RECENT FINDINGS: The use of spectral domain ocular coherence tomography to identify subretinal lesions has proven to be a reliable ally to clinicians...
November 2019: Current Opinion in Ophthalmology
Prih Rohra, Lei Yan, Fatima Mir, M Ryan Farrell, Paolo Gattuso, Lin Cheng
Despite being an important differential diagnosis of bladder tumor on cystoscopy, follicular cystitis (FC) is rarely diagnosed on cytologic material. We performed a retrospective study on cases of FC diagnosed on bladder biopsy and/or urine cytology in our institution. A total of 35 cases of FC were identified with a female predominance (F:M = 2:1). Hematuria was the most common clinical presentation. Cystoscopic findings included mass lesions, yellow plaques, and surface erythema. History of urinary tract infection was reported in 48% of the patients, and majority of those patients had positive concurrent urine culture, most commonly with beta-hemolytic streptococcus, Group B...
October 6, 2019: Diagnostic Cytopathology
Kelsey E McHugh, Edward B Stelow, Grant P Harrison, Maria Luisa C Policarpio-Nicolas
BACKGROUND: Solid pseudopapillary neoplasm (SPN) is an uncommon tumor that is challenging to diagnose on cytology due to morphologic overlap with other pancreatic neoplasms. Recently, putative diagnostic markers for SPN have been reported in the surgical pathology literature, with nuclear positivity for lymphoid enhancer-binding factor 1 (LEF1) and androgen receptor (AR) identified in >90% and >80% of cases, respectively. In the current study, the authors sought to evaluate the sensitivity and specificity of LEF1 and AR on SPN cytology specimens and available corresponding surgical resection specimens...
October 4, 2019: Cancer Cytopathology
Carol C Cheung, Penny Barnes, Gilbert Bigras, Scott Boerner, Jagdish Butany, Fiorella Calabrese, Christian Couture, Jean Deschenes, Hala El-Zimaity, Gabor Fischer, Pierre O Fiset, John Garratt, Laurette Geldenhuys, C Blake Gilks, Marius Ilie, Diana Ionescu, Hyun J Lim, Lisa Manning, Adnan Mansoor, Robert Riddell, Catherine Ross, Sinchita Roy-Chowdhuri, Alan Spatz, Paul E Swanson, Victor A Tron, Ming-Sound Tsao, Hangjun Wang, Zhaolin Xu, Emina E Torlakovic
Since 2014, programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) checkpoint inhibitors have been approved by various regulatory agencies for the treatment of multiple cancers including melanoma, lung cancer, urothelial carcinoma, renal cell carcinoma, head and neck cancer, classical Hodgkin lymphoma, colorectal cancer, gastroesophageal cancer, hepatocellular cancer, and other solid tumors. Of these approved drug/disease combinations, a subset also has regulatory agency-approved, commercially available companion/complementary diagnostic assays that were clinically validated using data from their corresponding clinical trials...
October 3, 2019: Applied Immunohistochemistry & Molecular Morphology: AIMM
T H Vu, M Kwon, S Ahmed, M Gule-Monroe, M M Chen, J Sun, B D Fornage, J M Debnam, B Edeiken-Monroe
The use of transoral sonography-guided fine-needle aspiration for intraoperative localization of retropharyngeal masses has been described by Fornage et al. The purpose of this study was to assess the accuracy of this technique. We reviewed the images and medical records of 26 patients with a retropharyngeal lesion suspicious for a metastatic lymph node of Rouviere identified on CT and/or PET/CT. There were 14 patients with a history of thyroid cancer, 7 with mucosal squamous cell carcinoma, 1 with renal cell carcinoma, 1 with parotid acinic cell cancer, 1 with metastatic colon adenocarcinoma, and 2 with no history of cancer...
October 3, 2019: AJNR. American Journal of Neuroradiology
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