Thomas M Raffay, Koby Bonilla-Fernandez, Anjum Jafri, Ramadan B Sopi, Laura A Smith, Feifei Cui, Maureen O'Reilly, Rongli Zhang, Craig A Hodges, Peter M MacFarlane, Gail Deutsch, Richard J Martin, Benjamin Gaston
Bronchopulmonary dysplasia (BPD) is characterized by alveolar simplification, airway hyperreactivity, and pulmonary hypertension. In our BPD model, we have investigated the metabolism of the bronchodilator and pulmonary vasodilator GSNO ( S -nitrosoglutathione). We have shown the GSNO catabolic enzyme encoded by adh5 (alcohol dehydrogenase-5), GSNO reductase, is epigenetically upregulated in hyperoxia. Here, we investigated the distribution of GSNO reductase expression in human BPD and created an animal model that recapitulates the human data...
July 2021: American Journal of Respiratory Cell and Molecular Biology