Yu-En Lin, Yi-Chun Chen, Kuan-Hung Lu, Yun-Ju Huang, Suraphan Panyod, Wei-Ting Liu, Shu-Hui Yang, Yun-Sheng Lu, Mei-Hsing Chen, Lee-Yan Sheen
ETHNOPHARMACOLOGY RELEVANCE: Cordyceps militaris (Linn.) Link (CM) is a medicinal mushroom traditionally used in tonics for treating several neurological disorders, including epilepsy and anxiety, in Asia. Reports have shown that CM has anti-inflammatory and anti-oxidative effects and may be beneficial for depression management. AIM OF THE STUDY: This study aimed to investigate the potential of CM as an antidepressant for a long-term unpredictable chronic mild stress (UCMS) rodent models and explore its underlying mechanisms...
May 8, 2021: Journal of Ethnopharmacology
Ming-Jen Lee, Jen-Chieh Lee, Jung-Hsien Hsieh, May-Yao Lin, I-An Shih, Huey-Ling You, Kai Wang
Neurofibromatosis type 1 (NF1) is one of the most common hereditary neurocutaneous disorders. In addition to skin pigmentation and cutaneous neurofibroma, some patients developed the plexiform neurofibroma since birth. Plexiform neurofibroma has abundant Schwann cells, fibroblasts, mast cells, blood vessels, and connective tissues, which increases the risk of developing a malignant peripheral nerve sheath tumor (MPNST). MPNST is a highly invasive cancer with no effective therapeutic agent. Cordycepin or 3'-deoxyadenosine is an extract from cordyceps militaris, which has been reported as an anti-inflammation and anti-tumor agent...
2021: American Journal of Cancer Research
Xiaoshuai Li, Jia Wang, Huayue Zhang, Long Xiao, Zhongfang Lei, Sunil C Kaul, Renu Wadhwa, Zhenya Zhang
Cordyceps militaris possesses several compounds with medicinal properties, and is commonly used in traditional Chinese functional food and medicine for a variety of health benefits. Because of its rare occurrence in nature, the market demand for artificial C. militaris is on the rise. Furthermore, efforts to increase its bioactive ingredients have also been considered in research. In this study, we aimed to investigate the effect of fluoride on the growth and enrichment of bioactive compounds in C. militaris ...
April 28, 2021: Journal of Fungi (Basel, Switzerland)
Farouq Heidar Barido, Sung Ki Lee
Objective: The effects of a crude protease extracted from Cordyceps militaris (CM) mushrooms on the postmortem tenderization mechanism and quality improvement in spent hen breast were investigated. Methods: Different percentages of the crude protease extracted from CM mushrooms were introduced to spent hen breast via spray marination, and its effects on tenderness-related indexes and proteolytic enzymes were compared to papain. Results: The results indicated that there was a possible improvement by the protease extracted from CM mushroom through the upregulation of endogenous proteolytic enzymes involved in the calpain system, cathepsin-B, and caspase-3 coupled with its nucleotide-specific impact...
April 23, 2021: Animal bioscience
Yefei Liu, Kun Xiao, Ze Wang, Shenghou Wang, Fangxu Xu
The objective of our study was to compare the chemical composition of Cordyceps sinensis (C. sinensis) and Cordyceps militaris (C. militaris) cultivated with tussah pupa by using metabonomics technology in order to clarify the similarity and difference of the two medicinal materials from the whole metabolite level. The results showed that there were 25 different metabolites among the 69 metabolites that were highly expressed in C. militaris cultivated with tussah pupa compared with C. sinensis in both positive and negative ion modes...
April 22, 2021: Journal of Food Biochemistry
Xiaoqian Yang, Ping Lin, Jin Wang, Na Liu, Fan Yin, Nuo Shen, Shoudong Guo
Hyperlipidemia is one major cause of atherosclerosis, which is a basic pathological change of cardiovascular diseases. Polysaccharide is a water-soluble component with lipid-lowering effects. In this study, alkaline-extracted polysaccharides were obtained from the fruiting body of C. militaris. Polysaccharides were purified via anion exchange and size exclusion chromatography. Their structural characteristics were investigated via chemical and spectroscopic methods. CM3I was mainly composed of →4)α-D-Glcp(1 → glycosyls and differed from starch due to the presence of →4,6)β-D-Glcp(1 → glycosyls...
April 17, 2021: International Journal of Biological Macromolecules
Ling-Sheng Zha, Vadim Yu Kryukov, Jian-Hua Ding, Rajesh Jeewon, Putarak Chomnunti
Species of Cordyceps sensu lato (Hypocreales, Sordariomycetes) have always attracted much scientific attention for their abundant species diversity, important medicinal values and biological control applications. The insect superfamilies Elateroidea and Tenebrionoidea are two large groups of Coleoptera and their larvae are generally called wireworms. Most wireworms inhabit humid soil or fallen wood and are often infected with Cordyceps s.l. However, the species diversity of Cordyceps s.l. on Elateroidea and Tenebrionoidea is poorly known...
2021: MycoKeys
Tatsuya Kato, Konomi Nishimura, Ahmad Suparmin, Kazuho Ikeo, Enoch Y Park
Cordyceps militaris produces cordycepin, a secondary metabolite that exhibits numerous bioactive properties. However, cordycepin pharmacology in vivo is not yet understood. In this study, the roles of cordycepin in C. militaris during its infection were investigated. After the injection of conidia, C. militaris NBRC100741 killed silkworm larvae more rapidly than NBRC103752. At 96 and 120 h, Cmcns genes ( Cmcns1 - 4 ), which are part of the cordycepin biosynthesis gene cluster, were expressed in fat bodies and cuticles...
March 25, 2021: Microorganisms
Toan Van Nguyen, Pramote Chumnanpuen, Kongphop Parunyakul, Krittika Srisuksai, Wirasak Fungfuang
Background and Aim: Cordyceps militaris (CM) is a fungus that has been used to enhance aphrodisiac activity in men, but to date, no studies have focused on its antidiabetic properties. This study aimed to investigate the effects of CM on reproductive performance of streptozotocin (STZ)-induced diabetic male rats. Materials and Methods: Six-week-old Wistar rats were randomly divided into four groups: control Group 1 consisting of healthy rats; Group 2, healthy rats treated with CM (100 mg/kg); Group 3, diabetic untreated rats; and Group 4, diabetic rats treated with CM (100 mg/kg)...
February 2021: Veterinary World
Xiao-Ying Yu, Yuan Zou, Qian-Wang Zheng, Feng-Xian Lu, De-Huai Li, Li-Qiong Guo, Jun-Fang Lin
The physicochemical and functional as well as structural properties of major protein fractions (albumin, globulin, glutelin) sequentially extracted in water, salt, alkaline solution respectively from Cordyceps militaris Minfu20 fruit body were investigated. The glutelin (43.11%, w/w) was the predominant protein component of C. militaris fruit body followed by albumin (36.47%) and globulin (17.94%). The three proteins extracted from different solvents showed different characteristics, which were related to the alternation of amino acid composition, surface hydrophobicity, and structural feature...
April 2021: Food Research International
Jin Wang, Yunhai Wang, Xiaoqian Yang, Ping Lin, Na Liu, Xinjian Li, Baihui Zhang, Shoudong Guo
One novel alkali-extracted polysaccharide, CM3-SII, was obtained from the fruiting body of C. militaris via column chromatography. Its structural characteristics were investigated via chemical and spectroscopic methods. The backbone of CM3-SII was composed of →4)-β-D-Manp(1→, →6)-β-D-Manp(1→, and →6)-α-D-Manp(1→ glycosyls, and branching at the O-4 positions of →6)-β-D-Manp(1→ glycosyls with β-D-Galp, (1→2) linked-β-D-Galf, and →2,6)-α-D-Manp(1→ residues. Furthermore, O-6 and O-2 positions of the →2,6)-α-D-Manp(1→ residues were substituted with methyl and β-D-Galp, respectively...
March 1, 2021: International Journal of Biological Macromolecules
Xiaoling Zhang, Xiaojing Zhang, Shuangshuang Gu, Lichao Pan, Huiqing Sun, Enlin Gong, Zhenyuan Zhu, Tingchi Wen, Ghoson Mosbah Daba, Waill Ahmed Elkhateeb
Iron-enriched Cordyceps militaris was obtained by adding FeSO4 solution to the mycelia for biotransformation. The polysaccharide-iron (III) was extracted by water extraction and alcohol precipitation. High performance liquid chromatography showed that the crude polysaccharide-iron (III) had three components. The second component was purified by Sephadex G-150 and named as CPS-iron-II. The average molecular weight of CPS-iron-II was 44.136 kDa. The content of iron was 2.73%. The monosaccharide composition analysis indicated that the CPS-iron-II was composed of rhamnose, arabinose, galactose, glucose, mannose, galacturonic acid with percentage ratio of 0...
February 25, 2021: International Journal of Biological Macromolecules
Xiao-Mei Zhang, De-Xiang Tang, Qing-Qing Li, Yuan-Bing Wang, Zhi-Hong Xu, Wen-Jun Li, Hong Yu
Cordyceps militaris is a traditional Chinese medicinal food that is challenging to quality maintaining while mass cultivation. Many studies have found that abundant microbes inhabit Ophiocordyceps sinensis and perform important functions for their host. In this study, our objective was to reveal the microbial communities that inhabit C. militaris and analyze their potential functions. High-throughput sequencing of 16S rRNA and ITS genes was used to compare the diversity and composition of the bacterial and fungal communities associated with naturally occurring C...
February 27, 2021: Antonie Van Leeuwenhoek
Ho-Sung Lee, In-Hee Lee, Kyungrae Kang, Sang-In Park, Seung-Joon Moon, Chol Hee Lee, Dae-Yeon Lee
Herbal medicines have drawn considerable attention with regard to their potential applications in breast cancer (BC) treatment, a frequently diagnosed malignant disease, considering their anticancer efficacy with relatively less adverse effects. However, their mechanisms of systemic action have not been understood comprehensively. Based on network pharmacology approaches, we attempted to unveil the mechanisms of FDY003, an herbal drug comprised of Lonicera japonica Thunberg, Artemisia capillaris Thunberg, and Cordyceps militaris , against BC at a systemic level...
2021: Evidence-based Complementary and Alternative Medicine: ECAM
Tian Lan, Yang Yu, Jing Zhang, Haonan Li, Qiqing Weng, Shuo Jiang, Song Tian, Tonghao Xu, Sha Hu, Guizhi Yang, Yan Zhang, Weixuan Wang, Lexun Wang, Qing Zhu, Xianglu Rong, Jiao Guo
BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD), especially the nonalcoholic steatohepatitis (NASH), have become a major cause of liver transplantation and liver-associated death. NASH is the hepatic manifestation of metabolic syndrome and is characterized by hepatic steatosis, inflammation, hepatocellular injury and different degrees of fibrosis. However, there is no FDA-approved medication to treat this devastating disease. Therapeutic activators of the AMP-Activated Protein Kinase (AMPK) have been proposed as a potential treatment for metabolic diseases such as NASH...
February 12, 2021: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Xiao-Ling Zhang, Wen-Min Huang, Pei-Chen Tang, Ying Sun, Xin Zhang, Lu Qiu, Bo-Cheng Yu, Xiao-Yan Zhang, Yu-Xin Hong, Yun He, Xiao-Qun Ge
Accumulating evidences suggest that inflammation-mediated neurons dysfunction participates in the initial and development of Parkinson's disease (PD), whereas mitochondria have been recently recognized as crucial regulators in NLRP3 inflammasome activation. Cordycepin, a major component of cordyceps militaris, has been shown to possess neuroprotective and anti-inflammatory activity. However, the effects of cordycepin in rotenone-induced PD models and the possible mechanisms are still not fully understood. Here, we observed that motor dysfunction and dopaminergic neurons loss induced by rotenone exposure were ameliorated by cordycepin...
February 4, 2021: Neurotoxicology
Eun-Ju Choi, Bohyeon Park, Joohyung Lee, Jooyoung Kim
Purpose: This study evaluated the anti-atopic dermatitis (AD) properties of Cordyceps militaris (CM) aqueous extract in keratinocytes in vitro and in vivo. We investigated the nutraceutical composition of the CM extract, including its protein, carbohydrate, and selected phytochemical content. Methods: The expression of pathogenic cytokines in keratinocytes was assayed using an in vitro model. The CM extract downregulated extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 kinase expression in TNFα/IFNγ-stimulated HaCaT cells...
December 2020: Physical activity and nutrition
Yujiao Chen, Yuqian Wu, Shouliang Li, Simiao Du, Xuemin Hao, Jian Zhang, Pengai Gu, Jiachen Sun, Lei Jiang, Qijin Gai, Xiaomin Liu, Kaimei Nie, Li Zhong, Guixue Wang, Jun Cao
We established a large-scale separation and purification platform to obtain kilogram amounts of natural compounds from the extraction of the fruiting bodies of C. militaris. Seven monomeric compounds, N6-(2-hydroxyethyl) adenosine (HEA), ergosterol (E), ergosta-7,22-diene-3,5,6-triol (EI), 5α,8α-epidioxy-(22E,24R)-ergosta-6,22-dien-3β-ol (ED),ergosta-7,22-dien-3β,5α-dihydroxy-6-one (EO), (20S,22E,24R)-Eegosta-7,22-dien-3β,5α,6β,9α-tetraol (ET), and (24S)-5,22-stigmastadien-3β-ol (SE), were harvested using different solvents, and the structure of each compound was identified...
December 31, 2020: European Journal of Medicinal Chemistry
Ting-Feng Wu, Wan-Yin Shi, Yi-Chen Chiu, Yu-Yi Chan
Cordyceps militaris has been widely studied for its various pharmacological activities such as antitumor, anti-inflammation, and immune regulation. The binding of an allergen to IgE-sensitized mast cells in nasal mucosa triggers allergic rhinitis. We found that oral administration of 300 mg/kg of the ethanol extract prepared from silkworm pupa-cultivated Cordyceps militaris fruiting bodies significantly alleviated the symptoms of ovalbumin-induced allergic rhinitis in mice, including sneeze/scratch, mast cell activation, eosinophil infiltration, and Syk activation...
January 12, 2021: Biomedicine & Pharmacotherapy
Xiao Li, Fen Wang, Yanyan Xu, Guijun Liu, Caihong Dong
Hydrophobins are a family of small secreted proteins found exclusively in fungi, and they play various roles in the life cycle. In the present study, genome wide analysis and transcript profiling of the hydrophobin family in Cordyceps militaris , a well-known edible and medicinal mushroom, were studied. The distribution of hydrophobins in ascomycetes with different lifestyles showed that pathogenic fungi had significantly more hydrophobins than saprotrophic fungi, and class II members accounted for the majority...
January 11, 2021: International Journal of Molecular Sciences
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