Claudio Bellevicine, Ilaria Migliatico, Roberta Sgariglia, Mariantonia Nacchio, Elena Vigliar, Pasquale Pisapia, Antonino Iaccarino, Dario Bruzzese, Francesco Fonderico, Domenico Salvatore, Bernadette Biondi, Stefania Masone, Vincenzo Novizio, Francesco Scavuzzo, Domenico Serino, Maurizio De Palma, Maria Grazia Chiofalo, Gerardo Botti, Luciano Pezzullo, Vincenzo Nuzzo, Stefano Spiezia, Giovanni De Chiara, Sergio Iorio, Giovanni Conzo, Giovanni Docimo, Antongiulio Faggiano, Massimo Bongiovanni, Umberto Malapelle, Annamaria Colao, Maria Triassi, Giancarlo Troncone
BACKGROUND: Thyroid fine-needle aspiration (FNA) is a reliable and cost-effective diagnostic tool for establishing the nature of thyroid nodules, although up to 30% of FNAs are still classified as "indeterminate." Molecular testing of FNAs could improve preoperative diagnosis, thereby reducing unnecessary surgery. In this multicenter prospective study the authors investigated, using a 7-gene assay, the distribution and diagnostic impact of BRAF, RAS, RET/PTC, and PAX8/PPARg, the most frequent genomic alterations occurring during thyroid oncogenesis...
February 2020: Cancer Cytopathology