keyword
https://read.qxmd.com/read/21442375/copper-and-zinc-serum-levels-after-derivative-bariatric-surgery-differences-between-roux-en-y-gastric-bypass-and-biliopancreatic-diversion
#41
COMPARATIVE STUDY
José A Balsa, José I Botella-Carretero, Jesús M Gómez-Martín, Roberto Peromingo, Francisco Arrieta, Carmen Santiuste, Isabel Zamarrón, Clotilde Vázquez
BACKGROUND: There are limited data on the prevalence of copper and zinc deficiency in the long term after bariatric surgery. METHODS: We analysed copper and zinc serum levels in a cohort of 141 patients, 52 who underwent Roux-en-Y gastric bypass (RYGB) and 89 biliopancreatic diversion (BPD), with a follow-up of 5 years. RESULTS: Mean copper level was significantly lower in the BPD group (P < 0.0001 vs. RYGB). Forty-five (50.6%) BPD patients had, at least once, a low copper level, and half of them, 27 (30...
June 2011: Obesity Surgery
https://read.qxmd.com/read/21236416/synthesis-physicochemical-and-spectroscopic-characterization-of-copper-ii-polysaccharide-pullulan-complexes-by-uv-vis-atr-ftir-and-epr
#42
JOURNAL ARTICLE
Zarko Mitić, Milorad Cakić, Goran M Nikolić, Ružica Nikolić, Goran S Nikolić, Radmila Pavlović, Enzo Santaniello
Bioactive copper(II) complexes with polysaccharides, like pullulan and dextran, are important in both veterinary and human medicine for the treatment of hypochromic microcitary anemia and hypocupremia. In aqueous alkaline solutions, Cu(II) ion forms complexes with the exopolysaccharide pullulan and its reduced low-molecular derivative. The metal content and the solution composition depend on pH, temperature, and time of the reaction. The complexing process begins in a weak alkali solution (pH >7) and involves OH groups of pullulan monomer (glucopyranose) units...
February 15, 2011: Carbohydrate Research
https://read.qxmd.com/read/21178710/pediatric-myelodysplastic-syndrome-with-cytoplasmic-vacuolation-in-myeloid-precursors
#43
JOURNAL ARTICLE
Dipanjan Panda, Nidhi Gupta, Ritu Gupta, Sameer Bakhshi
A 6-year-old boy presented with pancytopenia. Bone marrow morphology showed dyspoiesis and cytoplasmic vacuolation in myeloid precursor cells. Cytoplasmic vacuoles are described in erythroid cells in myelodysplastic syndrome (MDS) but are extremely rare in myeloid precursor cells. We ruled out viral and autoimmune etiology, hypocupremia, Pearson syndrome, and chromosomal abnormalities. Finally, a diagnosis of MDS of refractory cytopenia of childhood subtype was made. The patient then underwent an allogenic stem cell transplant that resulted in normalization of the complete blood counts and bone marrow morphology...
January 2011: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/21088385/hypocupremia-related-myeloneuropathy-following-gastrojejunal-bypass-surgery
#44
JOURNAL ARTICLE
Eric H Choi, Williamson Strum
Gastrojejunal bypass surgery may be complicated by nutritional deficiencies, including trace elements. Copper, which is absorbed in the duodenum and proximal jejunum, is poorly absorbed when a significant portion of the proximal small intestine is bypassed. However, despite this theoretical risk of hypocupremia in the gastrojejunal bypass patient, reports of symptomatic copper deficiency are very rare, and even then the deficiency is often potentiated by an accelerant, such as concomitant zinc ingestion. We report a case of hypocupremia resulting in hematologic abnormalities and myeloneuropathy after gastrojejunal bypass surgery for morbid obesity...
2010: Annals of Nutrition & Metabolism
https://read.qxmd.com/read/20732822/partial-status-epilepticus-induced-by-hypocupremia-in-a-patient-with-wilson-s-disease
#45
JOURNAL ARTICLE
Gulcin Benbir, Aysegul Gunduz, Sibel Ertan, Cigdem Ozkara
Although seizures are rarely encountered in Wilson's disease (WD), seizures related to hypocupremia have not been reported before. We report a patient presenting with partial status epilepticus who was on strict low-copper diet and chelating therapy for WD. Despite other rare causes of seizures in WD including penicillamine-induced pyridoxine deficiency, cerebral copper deposition and metabolic encephalopathy, the most probable cause of resistant status epilepticus in this patient was found as hypocupremia from overzealous treatment...
November 2010: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/20451943/combined-optic-neuropathy-and-myelopathy-secondary-to-copper-deficiency
#46
JOURNAL ARTICLE
Stacy L Pineles, Christina A Wilson, Laura J Balcer, Robert Slater, Steven L Galetta
We report two patients, both with a history of gastric surgery, who presented with progressive optic neuropathy and myelopathy. The patients' symptoms were initially attributed to vitamin B12 deficiency and/or neuromyelitis optica; however, after the neurologic deficits continued to progress with the use of conventional treatments, further evaluation was initiated, and a severe copper deficiency was revealed. Copper deficiency is a rare cause of progressive optic neuropathy and myelopathy and should be considered in the differential diagnosis...
July 2010: Survey of Ophthalmology
https://read.qxmd.com/read/19960761/hypocupremia-an-under-recognized-cause-of-subacute-combined-degeneration
#47
JOURNAL ARTICLE
Irene Y L Tan, Lyne Noël de Tilly, Trevor A Gray
It is increasingly evident that a multitude of etiologies can give rise to signal abnormality in the dorsal and lateral columns of the spinal cord, apart from pernicious anemia. We report a case of dorsal and lateral columns signal abnormality related to hypocupremia resulting in progressive sensory ataxia and weakness in the lower and upper limbs, compounded by a recent diagnosis of Sjögren's syndrome.
November 2009: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://read.qxmd.com/read/19732792/myelopolyneuropathy-and-pancytopenia-due-to-copper-deficiency-and-high-zinc-levels-of-unknown-origin-ii-the-denture-cream-is-a-primary-source-of-excessive-zinc
#48
JOURNAL ARTICLE
Peter Hedera, Amanda Peltier, John K Fink, Sandy Wilcock, Zachary London, George J Brewer
Neurodegeneration of the central and peripheral nervous system associated with hypocupremia and hyperzincinemia has been widely recognized but the origin of high zinc remained unknown. Denture cream has been recently suggested as one possible source of zinc, but the frequency with which denture fixative alone accounts for this syndrome is unknown. We analyzed the origin of excessive zinc in eleven patients with a progressive myelopolyneuropathy and unexplained hypocupremia with hyperzincinemia. These patients had a detailed clinical assessment, determination of zinc and copper levels, and analyzed use of denture cream with the estimates of daily zinc exposure...
November 2009: Neurotoxicology
https://read.qxmd.com/read/19484296/copper-uptake-by-pseudomonas-aeruginosa-isolated-from-infected-burn-patients
#49
COMPARATIVE STUDY
Muayad M Abboud, Humodi A Saeed, Khaled A Tarawneh, Khaled M Khleifat, Amjad Al Tarawneh
Pseudomonas aeruginosa was isolated from infected burn patients and characterized by standard biochemical tests. The in vitro copper uptake was compared between this isolated pathogenic strain and two non-pathogenic control strains of gram positive bacteria Bacillus thuringiensis strain Israelis as well as gram negative bacteria Enterobacter aerogenes. Maximum copper uptake of 470 ppm/g biomass was obtained by P. aeruginosa strain, while the control strains B. thuringiensis and Enterobacter aerogenes had copper uptake of 350 and 383 ppm/g biomass, respectively...
September 2009: Current Microbiology
https://read.qxmd.com/read/19365170/copper-deficiency-after-gastric-surgery-a-reason-for-caution
#50
JOURNAL ARTICLE
Calin I Prodan, Sylvia S Bottomley, Andrea S Vincent, Linda D Cowan, Beverley Greenwood-Van Meerveld, Neil R Holland, Stuart E Lind
BACKGROUND: : Acquired copper deficiency in adults leads to hematological and neurological manifestations that mimic vitamin B12 deficiency. A significant number of patients with copper deficiency syndrome have a history of gastric surgery, often remote. We sought to determine whether copper deficiency is present in a population of individuals with longstanding partial gastric resection. METHODS: : Serum copper, ceruloplasmin, and zinc levels were determined in 20 patients with a history of partial gastric resection and 50 controls, randomly selected from the Oklahoma City Veterans Affairs Medical Center electronic database...
April 2009: American Journal of the Medical Sciences
https://read.qxmd.com/read/18525032/denture-cream-an-unusual-source-of-excess-zinc-leading-to-hypocupremia-and-neurologic-disease
#51
JOURNAL ARTICLE
S P Nations, P J Boyer, L A Love, M F Burritt, J A Butz, G I Wolfe, L S Hynan, J Reisch, J R Trivedi
BACKGROUND: Chronic, excess zinc intake can result in copper deficiency and profound neurologic disease. However, when hyperzincemia is identified, the source often remains elusive. We identified four patients, one previously reported, with various neurologic abnormalities in the setting of hypocupremia and hyperzincemia. Each of these patients wore dentures and used very large amounts of denture cream chronically. OBJECTIVE: To determine zinc concentration in the denture creams used by the patients as a possible source of excess zinc ingestion...
August 26, 2008: Neurology
https://read.qxmd.com/read/18284630/hematological-manifestations-of-copper-deficiency-a-retrospective-review
#52
REVIEW
Thorvardur R Halfdanarson, Neeraj Kumar, Chin-Yang Li, Robert L Phyliky, William J Hogan
Copper deficiency is an established cause of hematological abnormalities but is frequently misdiagnosed. Copper deficiency can present as a combination of hematological and neurological abnormalities and it may masquerade as a myelodysplastic syndrome. We reviewed the records of patients with hypocupremia and hematologic abnormalities identified between 1970 and 2005. Patients with hypocupremia unrelated to copper deficiency (e.g. Wilson's disease) were excluded. Forty patients with copper deficiency and hematological abnormalities were identified...
June 2008: European Journal of Haematology
https://read.qxmd.com/read/18227802/altered-fluid-electrolyte-and-mineral-status-in-tropical-disease-with-an-emphasis-on-malaria-and-leptospirosis
#53
REVIEW
Visith Sitprija
Fluid, electrolyte and mineral perturbations are prevalent features of tropical disease. Hemodynamic alterations, fever, nitrogen wasting, and changes in membrane transport and acid-base balance contribute to these perturbations. Models of malaria and leptospirosis have been used to show that common hemodynamic changes in tropical disease include decreased systemic vascular resistance, increased cardiac output and increased renal vascular resistance. Blood volume is initially increased, but it decreases as disease progresses...
February 2008: Nature Clinical Practice. Nephrology
https://read.qxmd.com/read/18166767/hypocupremia-and-bone-marrow-failure
#54
JOURNAL ARTICLE
A S Haddad, V Subbiah, A E Lichtin, K S Theil, J P Maciejewski
Copper deficiency associated with neurological disorders is a well-documented condition. However, hypocupremia is less often recognized as a cause of cytopenias or bone marrow failure. We report an illustrative series of three new cases of bi-lineage cytopenia associated with copper deficiency. We have analyzed clinical features of current and historical cases to identify clues that could facilitate application of appropriate laboratory testing and heighten the level of clinical suspicion. By maintaining an appropriately high level of suspicion for potential copper deficiency and obtaining a serum copper level, bone marrow failure due to this condition can be correctly diagnosed and treated...
January 2008: Haematologica
https://read.qxmd.com/read/17894634/subacute-combined-degeneration-due-to-copper-deficiency
#55
JOURNAL ARTICLE
Joseph M Ferrara, Mark B Skeen, Nancy J Edwards, Linda Gray, E Wayne Massey
There is growing clinical evidence supporting a connection between copper deficiency and subacute combined degeneration. While nearly half of patients with copper deficiency myelopathy exhibit MRI abnormalities, signal changes are often ill-defined in distribution. We report a patient with sensory ataxia and spastic paraplegia from copper deficiency whose MRI demonstrates abnormal signal restricted to the dorsal and lateral columns, providing clear radiological support of an association between hypocupremia and combined system degeneration...
October 2007: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://read.qxmd.com/read/17259849/hypocupremia-associated-myelopathy
#56
JOURNAL ARTICLE
John W Allred, Joseph M Aulino
We present a 45-year-old man with copper deficiency (hypocupremia)-associated myelopathy. Acquired copper deficiency is a recently recognized cause of myelopathy in adults.
January 2007: Journal of Computer Assisted Tomography
https://read.qxmd.com/read/16986134/hypocupremia-associated-with-prior-vitamin-b12-deficiency
#57
JOURNAL ARTICLE
Calin I Prodan, Sylvia S Bottomley, Andrea S Vincent, Linda D Cowan, Neil R Holland, Stuart E Lind
Clinical similarities between vitamin B(12) and copper deficiencies prompted us to investigate if hypocupremia is present in patients receiving vitamin B(12) supplementation. Our pilot study results indicate that a significant number of elderly patients with prior diagnosis of vitamin B(12) deficiency have also undiagnosed hypocupremia.
April 2007: American Journal of Hematology
https://read.qxmd.com/read/16679666/cns-demyelination-due-to-hypocupremia-in-wilson-s-disease-from-overzealous-treatment
#58
JOURNAL ARTICLE
Sunil K Narayan, Nandigam Kaveer
No abstract text is available yet for this article.
March 2006: Neurology India
https://read.qxmd.com/read/16479727/short-term-exogenous-glucocorticosteroidal-effect-on-iron-and-copper-status-in-canine-leishmaniasis-leishmania-infantum
#59
JOURNAL ARTICLE
K K Adamama-Moraitou, M N Saridomichelakis, Z Polizopoulou, M Kritsepi, A Tsompanakou, A F Koutinas
Prednisolone was administered as an anti-inflammatory for 7 consecutive days in 11 dogs with leishmaniasis (CL group) and 5 clinically normal dogs (control group). After a 15-day wash-out phase, the same medication was given as an immunosuppressive for another 7-day period. In both animal groups and experimental periods an overall significant increase of serum iron and transferrin saturation was noted. Serum copper showed a significant increase during the anti-inflammatory period in the control group and a significant decrease during the immunosuppressive period in the CL group...
October 2005: Canadian Journal of Veterinary Research
https://read.qxmd.com/read/16363328/the-effect-of-gastrointestinal-parasitism-on-blood-copper-and-hemoglobin-levels-in-sheep
#60
JOURNAL ARTICLE
A Adogwa, A Mutani, A Ramnanan, C Ezeokoli
Endoparasitism is a problem in Trinidad, as it is in most tropical countries. Parasite infection has been suspected to contribute to the pathogenesis of swayback disease (which is also prevalent in Trinidad), but the mode of action has not been clearly defined, although it has been suggested that parasites interfere with the absorption of copper from the gastrointestinal tract. The objectives of the study were to assess the effect of endoparasitism on blood copper levels and hemoglobin (Hb) concentration in sheep in Trinidad...
November 2005: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
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