Marlene Fabiola Escobedo-Monge, Enrique Barrado, Carmen Alonso Vicente, María Antonieta Escobedo-Monge, María Carmen Torres-Hinojal, José Manuel Marugán-Miguelsanz, María Paz Redondo Del Río
Cystic fibrosis (CF) patients require a stable and sufficient supply of micronutrients. Since copper is an essential micronutrient for human development, a cross-sectional study was carried out to investigate the serum copper levels, serum copper/zinc (Cu/Zn) ratios, and their relationship with nutritional indicators in a group of CF patients. Anthropometric, biochemical, and dietary measurements, an abdominal ultrasound, and respiratory and pancreatic tests were conducted. Seventeen CF patients were studied (10 females, 59%), 76...
October 30, 2020: Nutrients
Ahsan Wahab, Kamran Mushtaq, Samuel G Borak, Naresh Bellam
Hypocupremia due to zinc products can cause sideroblastic anemia and neutropenia and mimics other serious hematological disorders. Early consideration of the copper deficiency and a thorough clinical history can prevent unnecessary interventions.
September 2020: Clinical Case Reports
Dominic Butcher, Simona Deplano, Thomas Lofaro
Copper deficiency can produce changes mimicking myelodysplasia, but its prevalence among haematology patients is unknown. This study evaluates the prevalence of deficiency in a population of patients with unexplained cytopenia(s) and dysplasia. Of 17 patients recruited, only one was found to have a low copper level. This is the first study evaluating hypocupremia in patients with isolated haematological manifestations. Our results suggest that copper deficiency is uncommon in this population, and the routine measurement of copper seems unlikely to be cost-effective...
June 2, 2020: Biological Trace Element Research
Vineeth Tatineni, Julie Y An, Matthew R Leffew, Sameer A Mahesh
Hypocupremia can result in a bi-lineage deficiency of leukocytes and erythrocytes. Although commonly seen from gastrointestinal malabsorption, hypocupremia can be further exacerbated with excessive zinc intake causing increased fecal copper excretion. Dietary supplementation is prevalent in the outpatient setting and must be considered as a possible source of hematologic pathologies.
April 2020: Clinical Case Reports
Charlene L Rohm, Sara Acree, Louis Lovett
Hypocupremia is a rare and under-recognised cause of bone marrow dysplasia and myeloneuropathy. A 47-year-old Caucasian woman had progressive ascending peripheral neuropathy and gait ataxia over 3 months and fatigue, dyspnoea and unintentional weight loss over 8 months. She had profound macrocytic anaemia and neutropenia. Initial workup included normal serum vitamin B12 Bone marrow biopsy was suggestive of copper deficiency. Serum copper levels were later confirmed to be undetectable. The patient received oral copper repletion which resulted in complete normalisation of haematological abnormalities 16 weeks later...
December 2, 2019: BMJ Case Reports
María Teresa Fernández López, Cristina Guillín Amarelle, José Antonio Mato Mato
INTRODUCTION: we report a patient with transthyretin familial amyloid polyneuropathy (TTR-FAP) and severe hypocupremia. CASE REPORT: a 79-year-old male with TTR-FAP and severe malnutrition. Laboratory tests showed low serum copper (Cu) and ceruloplasmin levels, as well as low urinary Cu levels. The patient reported neither digestive symptoms nor previous gastrointestinal surgery. Liver function tests, iron metabolism, hemoglobin, leukocytes and zinc were normal...
December 3, 2019: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Itaru Ozeki, Tomoaki Nakajima, Hirokazu Suii, Ryoji Tatsumi, Masakatsu Yamaguchi, Tomohiro Arakawa, Yasuaki Kuwata, Joji Toyota, Yoshiyasu Karino
AIM: In Japan, no zinc preparation had been approved for therapeutic purposes. Zinc acetate hydrate was recently approved for the treatment of hypozincemia. We evaluated the efficacy and safety of treatment with zinc acetate hydrate. METHODS: A total of 97 patients with cirrhosis complicated by hypozincemia were treated with zinc acetate hydrate and their serum zinc normalization rates; factors contributing to normalization; changes in blood ammonia levels; branched-chain amino acids to tyrosine ratios (BTR); levels of albumin, hemoglobin, alkaline phosphatase (ALP), serum copper, and iron; incidence of adverse events; improvement in subjective symptoms; and serum zinc levels determined at 3 months post-treatment were determined...
November 14, 2019: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Sha Cai, Jing-Yu Gong, Jing Yang, Jian-She Wang
BACKGROUND: Zinc therapy is considered an effective and safe treatment for Wilson's disease. Hypocupremia-related anemia is rarely reported after long-term zinc administration or combination therapy with copper-chelating agent. CASE PRESENTATION: We herein report a 12-year-old girl with pre-symptomatic Wilson's disease diagnosed 5 years ago who presented with severe anemia after high-dose oral zinc for 4 years and 4 months. Her hemoglobin was gradually restored to the normal range after the adjustment of zinc dose and diet therapy for 4 months...
July 9, 2019: BMC Gastroenterology
Andrey Arturo Flores-Pulido, Víctor Manuel Jiménez-Pérez, Néstor Rodolfo García-Chong
Menkes disease is a neurodegenerative and lethal pathology caused by gene mutations of the copper-transporting ATP-7A enzyme; it manifests itself by neurological symptoms and connective tissue changes of varying severity. Timely subcutaneous use of copper histidinate (Cu-His) is determinant for quality of life. We report the first experiences in Mexico on Cu-His synthesis and its safe use in 3 cases where hypocupremia and hypoceruloplasminemia were corroborated. With advice of the Hospital for Sick Children of Toronto Canada, we prepared a 500 µg/mL solution...
2019: Gaceta Médica de México
Jin Jun Luo, Favio Bumanlag, Nae Dun
Copper deficiency (hypocupremia) or toxicosis (hypercupremia) may cause disorders of central and peripheral nervous systems. Hypocupremia causes myeloneuropathy resembling vitamin B12 deficiency. However, the clinical manifestations, particularly peripheral neuropathy (PN), of hypercupremia have not been adequately evaluated. To compare clinical, laboratory and electrodiagnositc features of PN between patients with hypocupremia and hypercupremia, we retrospectively reviewed the charts of patients with abnormal copper levels...
May 15, 2019: Journal of the Neurological Sciences
J David Avila, David Lacomis
Celiac disease has been associated with several neurologic disorders which may result from micronutrient deficiencies, coexisting autoimmune conditions, or gluten sensitivity. Copper deficiency can produce multiple neurologic manifestations. Myeloneuropathy is the most common neurologic syndrome and it is often irreversible, despite copper replacement. We report the case of a 55-year-old man who presented with progressive proximal limb weakness and weight loss in the setting of untreated celiac disease without gastrointestinal symptoms...
2016: Case Reports in Neurological Medicine
S Ferdousi, S Akhtar, S Begum
This study assessed maternal serum copper and zinc levels in preeclampsia to find out the role of trace element disorder in the aetiology of preeclampsia. This cross sectional study was conducted in the dept of Physiology of BSMMU during 2009. Sixty patients of Preeclampsia (BP--140/90 aged 18-39 years, with >20th weeks of pregnancy with proteinuria and edema) participated. Thirty normotensive gravida was control. All subjects were collected from in and out patient department of Obstetric and Gynecology of BSMMU and Dhaka medical college hospital...
October 2015: Mymensingh Medical Journal: MMJ
Masatoshi Nakagawa, Kazuyuki Kojima, Mikito Inokuchi, Keiji Kato, Hirofumi Sugita, Sho Otsuki, Kyoko Higuchi, Kenta Kobayashi, Kenichi Sugihara
BACKGROUND: Some recent reports have noted that copper deficiency can occur in obese patients who have undergone bariatric surgery, such as Roux-en-Y (RY) gastric bypass or biliopancreatic diversion, or in patients who receive enteral nutrition through a jejunostomy. No reports appear to have assessed the serum copper state of patients following gastrectomy with RY reconstruction for gastric cancer. METHODS: A cross-sectional study was conducted from June 2013 to December 2014...
2015: Digestive Surgery
Camila Bitu Moreno Braga, Iahel Manon de Lima Ferreira, Júlio Sérgio Marchini, Selma Freire de Carvalho da Cunha
BACKGROUND: Patients with short bowel syndrome have significant fluid and electrolytes loss. OBJECTIVE: Evaluate the mineral and electrolyte status in short bowel syndrome patients receiving intermittent parenteral nutrition or oral feeding. METHODS: Twenty two adults with short bowel syndrome, of whom 11 were parenteral nutrition dependent (PN group), and the 11 remaining had been weaned off parenteral nutrition for at least 1 year and received all nutrients by oral feeding (OF group)...
April 2015: Arquivos de Gastroenterologia
Aarathi R Rau, M Usha, Pooja Mallya, A T K Rau
We describe a sixteen year old with Wilson's disease on copper chelation and subsequent high dose oral zinc who developed severe anemia and neutropenia. Bone marrow aspirate done to evaluate the cause of bicytopenia revealed trilineage dysplasia. Correlating the clinical context with bone marrow and biochemical parameters, copper deficiency was suspected and he was given a trial of therapy, following which the hematological parameters improved. This case highlights hypocupremia as a reversible cause of bone marrow dysplasia in patients with Wilson's disease on chelation, where serum copper levels are not useful in the diagnosis...
September 2014: Indian Journal of Hematology & Blood Transfusion
Rekha Bhat, Swati Pai, Ashish Dixit
Copper plays an essential role in numerous enzymatic reactions in the human body and hypocupremia manifests itself as cytopenias and/or neuropathy. Copper deficiency is also a mimic of dysplasia, and this may cause diagnostic difficulties with true myelodysplasia. In this case report, we present a patient with anaemia, thrombocytopenia and marginally decreased leucocyte count, who was found to have low copper levels. In addition, he had isolated 20q deletion and a small paroxysmal nocturnal haemoglobinuria clone, which have not been reported previously...
September 2014: Indian Journal of Hematology & Blood Transfusion
Shivam Om Mittal, Duarte G Machado
BACKGROUND: We report a patient, diagnosed with late cortical cerebellar atrophy, who had persistent low serum copper levels. CASE REPORT: A 48-year-old male developed progressive difficulty with balance, frequent falls, and dysarthric speech, which worsened over a short time span. He had an extensive ataxia work-up, which was unremarkable except for persistent low serum copper levels despite adequate supplementation. Magnetic resonance imaging of the brain showed marked cerebellar atrophy...
2014: Tremor and Other Hyperkinetic Movements
H Kodera, N Ando, I Yuasa, Y Wada, Y Tsurusaki, M Nakashima, N Miyake, S Saitoh, N Matsumoto, H Saitsu
The conserved oligomeric Golgi (COG) complex is involved in intra-Golgi retrograde trafficking, and mutations in six of its eight subunits have been reported in congenital disorders of glycosylation (CDG). Here we report a patient showing severe acquired microcephaly, psychomotor retardation, seizures, liver dysfunction, hypocupremia, and hypoceruloplasminemia. Analysis of his serum glycoproteins revealed defects in both sialylation and galactosylation of glycan termini. Trio-based whole-exome sequencing identified two heterozygous mutations in COG2: a de novo frameshift mutation [c...
May 2015: Clinical Genetics
Sara D Robinson, Barry Cooper, Temekka V Leday
Hypocupremia, or copper deficiency, is a rare and underrecognized cause of bone marrow dysplasia. Most cases of copper deficiency in adults occurred historically in patients receiving total parenteral hyperalimentation or total parental nutrition. More recently, with the obesity epidemic and the prevalence of gastric bypass, cases of malabsorption-related copper deficiency have occurred. Copper deficiency can lead to significant cytopenias and possible neurologic sequelae, which can be misdiagnosed and mismanaged...
October 2013: Proceedings of the Baylor University Medical Center
Farhard Khimani, Ryan Livengood, Olukemi Esan, Jeffrey A Vos, Vivek Abhyankar, Ludwig Gutmann, William Tse
Copper deficiency resulting in hypocupremia is a rare cause of pancytopenia associated with a neurological syndrome. Hypocupremia may also occur as a consequence of excessive oral zinc consumption as described by Brewer et al and several other groups. Dental fixatives have been described as a potential source of hyperzincemia in patients. Despite the recently modified dental fixatives with safer zinc content, zinc poisoning results in hypocupremia secondary to inappropriate use of them can still happen and more likely be misdiagnosed...
2013: American Journal of Stem Cells
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