Gregory S Phillips, Stephanie Mengden-Koon, Julie Dhossche, Philip E LeBoit, Alisa M Goldstein, Ina Lee, Mark Raffeld, Antonios Papanicolau-Sengos, Michael R Sargen, Jina Chung
A host of signature genetic alterations have been demonstrated in Spitz neoplasms, most notably fusions of kinase genes (including BRAF, ALK, ROS1, NTRK1, NTRK3, RET, MET, MAP3K8) or variants in HRAS. While there are multiple reports of rearrangements involving NTRK1 and NTRK3 in Spitz tumors, there are very few reports of NTRK2-rearranged Spitz nevi in the literature. This report presents an NTRK2-rearranged atypical Spitz tumor with spindled cell features. The patient was a 6-year-old female with a growing pigmented papule on the back...
November 29, 2023: Journal of Cutaneous Pathology