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RANDOMIZED CONTROLLED TRIAL
Nasamon Wanlapakorn, Nasiri Sarawanangkoor, Donchida Srimuan, Thaksaporn Thatsanathorn, Thanunrat Thongmee, Yong Poovorawan
Thailand has incorporated the whole-cell (wP) pertussis vaccine into the expanded program on immunization since 1977 and has offered the acellular pertussis (aP) vaccine as an optional vaccine for infants since 2001. We followed healthy children from a clinical trial (ClinicalTrials.gov NCT02408926) in which children were randomly assigned to receive either pentavalent (DTwP-HB-Hib) or hexavalent (DTaP-IPV-HB-Hib) vaccines for their primary series (administered at 2, 4, and 6 months) and first booster vaccination (18 months)...
December 31, 2024: Human Vaccines & Immunotherapeutics
#2
JOURNAL ARTICLE
Gi-Sub Choi, Kyu-Ri Kang, Seung-Bum Kim, Joon-Hwan Ji, Gyu-Won Cho, Hyun-Mi Kang, Jin-Han Kang
PURPOSE: Pertussis bacteria have many pathogenic and virulent antigens and severe adverse reactions have occurred when using inactivated whole-cell pertussis vaccines. Therefore, inactivated acellular pertussis (aP) vaccines and genetically detoxified recombinant pertussis (rP) vaccines are being developed. The aim of this study was to assess the safety profile of a novel rP vaccine under development in comparison to commercial diphtheria-tetanus-acellular pertussis (DTaP) vaccines. MATERIALS AND METHODS: The two positive control DTaP vaccines (two- and tri-components aP vaccines) and two experimental recombinant DTaP (rDTaP) vaccine (two- and tri-components aP vaccines adsorbed to either aluminum hydroxide or purified oat beta-glucan) were used...
April 2024: Clinical and Experimental Vaccine Research
#3
REVIEW
Mengistie Kassahun Tariku, Abebe Habtamu Belete, Daniel Tarekegn Worede, Simachew Animen Bante, Agumas Alemu Alehegn, Biniam Kebede Assen, Bantayehu Addis Tegegne, Sewnet Wongiel Misikir
BACKGROUND: Pertussis, a highly contagious, vaccine-preventable respiratory infection caused by Bordetella pertussis, is a leading global public health issue. Ethiopia is currently conducting multiple pertussis outbreak investigations, but there is a lack of comprehensive information on attack rate, case fatality rate, and infection predictors. This study aimed to measure attack rates, case fatality rates, and factors associated with pertussis outbreak. METHODS: This study conducted a systematic review and meta-analysis of published and unpublished studies on pertussis outbreaks in Ethiopia from 2009 to 2023, using observational study designs, using the guideline Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
May 15, 2024: Journal of Epidemiology and Global Health
#4
JOURNAL ARTICLE
Sonwabile Dzanibe, Aaron J Wilk, Susan Canny, Thanmayi Ranganath, Berenice Alinde, Florian Rubelt, Huang Huang, Mark M Davis, Susan P Holmes, Heather B Jaspan, Catherine A Blish, Clive M Gray
While preventing vertical HIV transmission has been very successful, HIV-exposed uninfected infants (iHEU) experience an elevated risk to infections compared to HIV-unexposed and uninfected infants (iHUU). Here we present a longitudinal multimodal analysis of infant immune ontogeny that highlights the impact of HIV/ARV exposure. Using mass cytometry, we show alterations in T cell memory differentiation between iHEU and iHUU being significant from week 15 of life. The altered memory T cell differentiation in iHEU was preceded by lower TCR Vβ clonotypic diversity and linked to TCR clonal depletion within the naïve T cell compartment...
May 14, 2024: Nature Communications
#5
JOURNAL ARTICLE
Simin Zargarani, Maryam J Tavaf, Azita Soltanmohammadi, Esmaeil Yazdanpanah, Rasoul Baharlou, Bahman Yousefi, Bizhan Sadighimoghaddam, Seyed-Alireza Esmaeili, Dariush Haghmorad
The most common central nervous system (CNS) inflammatory disease is multiple sclerosis (MS), modeled using experimental autoimmune encephalomyelitis (EAE). Mesenchymal stem cells (MSCs) exhibit potent immunomodulatory capabilities, including the suppression of immune cell functions and anti-inflammatory cytokine production. Female C57BL/6 mice (8-10 weeks old) were divided into three groups: 1. Control, 2. Allogeneic MSCs (ALO) treatment, and 3. Syngeneic MSCs (SYN) treatment. To induce EAE, myelin oligodendrocyte glycoprotein was injected subcutaneously with complete Freund's adjuvant, followed by intraperitoneal pertussis toxin...
May 14, 2024: Cell Biology International
#6
JOURNAL ARTICLE
Alexander J Mentzer, Alexander T Dilthey, Martin Pollard, Deepti Gurdasani, Emre Karakoc, Tommy Carstensen, Allan Muhwezi, Clare Cutland, Amidou Diarra, Ricardo da Silva Antunes, Sinu Paul, Gaby Smits, Susan Wareing, HwaRan Kim, Cristina Pomilla, Amanda Y Chong, Debora Y C Brandt, Rasmus Nielsen, Samuel Neaves, Nicolas Timpson, Austin Crinklaw, Cecilia S Lindestam Arlehamn, Anna Rautanen, Dennison Kizito, Tom Parks, Kathryn Auckland, Kate E Elliott, Tara Mills, Katie Ewer, Nick Edwards, Segun Fatumo, Emily Webb, Sarah Peacock, Katie Jeffery, Fiona R M van der Klis, Pontiano Kaleebu, Pandurangan Vijayanand, Bjorn Peters, Alessandro Sette, Nezih Cereb, Sodiomon Sirima, Shabir A Madhi, Alison M Elliott, Gil McVean, Adrian V S Hill, Manjinder S Sandhu
How human genetic variation contributes to vaccine effectiveness in infants is unclear, and data are limited on these relationships in populations with African ancestries. We undertook genetic analyses of vaccine antibody responses in infants from Uganda (n = 1391), Burkina Faso (n = 353) and South Africa (n = 755), identifying associations between human leukocyte antigen (HLA) and antibody response for five of eight tested antigens spanning pertussis, diphtheria and hepatitis B vaccines...
May 13, 2024: Nature Medicine
#7
JOURNAL ARTICLE
Sara Banaeeyeh, Amir Afkhami-Goli, Zahra Moosavi, Bibi Marjan Razavi, Hossein Hosseinzadeh
Multiple sclerosis (MS) is an autoimmune disorder characterized by the degeneration of myelin and inflammation in the central nervous system. Trans sodium crocetinate (TSC), a novel synthetic carotenoid compound, possesses antioxidant, anti-inflammatory and neuroprotective effects. This study aimed to evaluate the protective effects of TSC against the development of experimental autoimmune encephalomyelitis (EAE), a well-established model for MS. Female BALB/C57 mice were divided into different groups, including control, EAE, vehicle, TSC-treated (25, 50, and 100 mg/kg, administered via gavage) + EAE, methyl prednisone acetate + EAE, and TSC-treated (100 mg/kg, administered via gavage for 28 days) groups...
May 13, 2024: Metabolic Brain Disease
#8
REVIEW
Nicole U Stoffel, Hal Drakesmith
Vaccines can prevent infectious diseases, but their efficacy varies, and factors impacting vaccine effectiveness remain unclear. Iron deficiency is the most common nutrient deficiency, affecting over 2 billion individuals. It is particularly common in areas with high infectious disease burden and in groups that are routinely vaccinated, such as infants, pregnant women, and the elderly. Recent evidence suggests that iron deficiency and low serum iron (hypoferremia) not only cause anemia, but also may impair adaptive immunity and vaccine efficacy...
May 8, 2024: Advances in Nutrition
#9
REVIEW
Shuai Guo, Yu Zhu, Qin Guo, Chaomin Wan
BACKGROUND: Pertussis (Whooping Cough) is a respiratory infection caused by Bordetella pertussis . Pertussis usually occurs in childhood; severe infections are most common in infants. It can be fatal with severe complications such as pulmonary hypertension, heart failure, and encephalitis. OBJECTIVES: We sought to synthesize the existing literature on severe pertussis in infants and inform further study. METHODS: A scoping review was performed based on the methodological framework developed by Arksey & O'Malley...
December 2024: Annals of Medicine
#10
JOURNAL ARTICLE
Zosia Kmietowicz
No abstract text is available yet for this article.
May 9, 2024: BMJ: British Medical Journal
#11
JOURNAL ARTICLE
Kangguo Li, Jia Rui, Wentao Song, Li Luo, Yunkang Zhao, Huimin Qu, Hong Liu, Hongjie Wei, Ruixin Zhang, Buasiyamu Abudunaibi, Yao Wang, Zecheng Zhou, Tianxin Xiang, Tianmu Chen
The coronavirus disease 2019 (COVID-19) pandemic, along with the implementation of public health and social measures (PHSMs), have markedly reshaped infectious disease transmission dynamics. We analysed the impact of PHSMs on 24 notifiable infectious diseases (NIDs) in the Chinese mainland, using time series models to forecast transmission trends without PHSMs or pandemic. Our findings revealed distinct seasonal patterns in NID incidence, with respiratory diseases showing the greatest response to PHSMs, while bloodborne and sexually transmitted diseases responded more moderately...
May 8, 2024: Nature Communications
#12
JOURNAL ARTICLE
Winnie Siu, Angela Sinilaite, Jesse Papenburg
BACKGROUND: Seasonal influenza infection can lead to serious complications and adverse outcomes for pregnant individuals, the developing fetus and infants younger than six months of age. This supplemental statement provides an evidence summary on the safety and effectiveness of influenza vaccination in pregnant individuals, and the benefits and risks to the pregnant person, the developing fetus and infants younger than six months of age. METHODS: A systematic review was conducted on the effectiveness and safety of influenza vaccination in pregnancy...
April 30, 2024: Canada Communicable Disease Report
#13
JOURNAL ARTICLE
Ramon A Juste, Kalliopi Vrotsou, Maider Mateo-Abad, Maria A Gutiérrez-Stampa, Rafael Rotaeche, Itziar Vergara, Luis Bujanda
Trained immunity (TRAIM) or the enhanced non-specific immune response after primary stimulation by infection or vaccination is a recent but well-recognized concept. To verify its predictions, our objective was to determine the effects of two bacterial vaccines, typhoid fever (TFV) and diphtheria-tetanus-pertussis (DTP) on the infection, hospitalization and death frequencies associated to COVID-19 in a retrospective study on subjects vaccinated or not with TFV and DTP in the 4 years prior to the start of COVID-19 pandemia in the Basque Country (Spain)...
May 15, 2024: Heliyon
#14
JOURNAL ARTICLE
Dr Jo Parsons, Dr Cath Grimley, Professor Helen Atherton, Louise Clarke, Dr Sarah Hillman, Professor Debra Bick
BACKGROUND: Pregnant women and their unborn babies are at increased risk from serious complications, hospitalisation and death from infectious diseases. Vaccinations for influenza (flu), pertussis (whooping cough) and Covid-19 are available for free for pregnant women in the UK, but uptake of these repeatedly remains low. This qualitative study aimed to explore how pregnant women feel about these vaccinations, and what factors influence the uptake of vaccinations amongst pregnant women since the onset of the Covid-19 pandemic...
April 29, 2024: Midwifery
#15
JOURNAL ARTICLE
Jiajing Scarlette Shi, Ankit Sutaria, Sangeetha Lakshmanan, Brandon Attell, Mei Zhou, Amy Tang, James Eckman, Angela Snyder
INTRODUCTION: Despite the importance of timely vaccine completion for protection from infectious disease, there is limited knowledge of the immunization adherence rates of children with sickle cell disease (SCD). METHODS: This is a retrospective cohort study comparing the immunization rates of children with SCD to those with sickle cell trait between 2008 and 2019 in Georgia. Completion rates for each vaccine and the proportion of children with up-to-date status at 24 and 35 months were calculated and compared between the cohorts...
May 3, 2024: Pediatric Blood & Cancer
#16
JOURNAL ARTICLE
Wei Chen, Haoquan Zhou
OBJECTIVE: Metagenomic sequencing (mNGS) is a promising technique for pathogen detection. However, the use of mNGS in pediatric lung infections is still rarely reported. METHODS: A total of 59 cases were included between January 2019 and December 2021. To compare the performance of mNGS and routine detection in diagnosing pulmonary infection and identifying pathogenic bacteria. RESULTS: 59 children (33.90%) were infected with Mycoplasma pneumoniae, 15 were infected with adenovirus type 7 (25...
May 3, 2024: Alternative Therapies in Health and Medicine
#17
JOURNAL ARTICLE
Wendy Pringle, Devon Greyson, Janice E Graham, Ève Dubé, Hana Mitchell, Margaret L Russell, Shannon E MacDonald, Julie A Bettinger
OBJECTIVE: Successful clinical conversations about vaccination in pregnancy (pertussis, COVID-19, and influenza) are key to improving low uptake rates of both vaccination in pregnancy and infancy. The purpose of this study was to understand Canadian perinatal care providers' knowledge, attitudes, and practices around vaccination in pregnancy. METHODS: Qualitative interviews with 49 perinatal care providers (nurse practitioner, general practitioner, registered nurse, registered midwife, obstetrician-gynecologist, and family physicians) in 6 of 13 provinces and territories were deductively coded using directed content analysis [1] and analyzed according to key themes...
June 2024: Vaccine: X
#18
MULTICENTER STUDY
Saba Berhie, Deborah Kacanek, Jessica Lee, Jennifer Jao, Kathleen Powis, Liz Salomon, Danish Siddiqui, Lynn M Yee
IMPORTANCE: Pregnancy represents a window of opportunity for vaccination due to established maternal and fetal benefits of vaccination. Little is known about receipt of routinely recommended vaccines in pregnancy, specifically tetanus, diphtheria, plus acellular pertussis (Tdap) and influenza, among pregnant people living with HIV (PLHIV). OBJECTIVE: To estimate prevalence of vaccination receipt among pregnant people with HIV (PLHIV) and identify demographic and clinical characteristics associated with vaccination...
May 1, 2024: JAMA Network Open
#19
REVIEW
Yao Zhu, Wanting Zhang, Jie Hu, Shuying Luo, Yang Zhou, Xuewen Tang, Rui Yan, Xuan Deng, Hanqing He
Pertussis is a vaccine-preventable infectious disease; however, data on pertussis antibody levels in a nationwide population are still limited in China. We aimed to pool the seropositivity rates of IgG antibodies against pertussis toxin (PT-IgG) across the country. We systematically searched PubMed, Web of Science, Embase, and the China National Knowledge Infrastructure Database for studies published between January 1, 2010, and June 30, 2023. Studies reporting the seroprevalence of PT-IgG among a healthy Chinese population were included...
December 31, 2024: Human Vaccines & Immunotherapeutics
#20
JOURNAL ARTICLE
Samuel John E Parreño
BACKGROUND: Public health surveillance is vital for monitoring and controlling disease spread. In the Philippines, an effective surveillance system is crucial for managing diverse infectious diseases. The Newcomb-Benford Law (NBL) is a statistical tool known for anomaly detection in various datasets, including those in public health. METHODS: Using Philippine epidemiological data from 2019 to 2023, this study applied NBL analysis. Diseases included acute flaccid paralysis, diphtheria, measles, rubella, neonatal tetanus, pertussis, chikungunya, dengue, leptospirosis and others...
May 1, 2024: Journal of Public Health
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