Jesús A Velásquez, Richard M Burwick, Alyssa R Hersh, Jaime L Silva, Viviana Lenis, Yamile Bernal, Johanna Vargas, Catalina Valencia, Jorge H Gutiérrez, Francisco Edna, Juliana Trujillo, Mónica Rincón, Maria I Alvarez, Jorge E Tolosa
OBJECTIVES: Dysregulation of CD59 may lead to increased complement-mediated end-organ injury in preeclampsia. We sought to determine if soluble CD59 concentrations are altered in preeclampsia with severe features. STUDY DESIGN: Observational case-control study, which enrolled subjects prospectively from six centers in Colombia from 2015 to 2016. Cases had preeclampsia with severe features and controls were either healthy or had chronic hypertension, gestational hypertension, or preeclampsia without severe features...
October 14, 2020: Pregnancy Hypertension
Ying Li, Jin-Gang Hou, Zhi Liu, Xiao-Jie Gong, Jun-Nan Hu, Ying-Ping Wang, Wen-Cong Liu, Xiang-Hui Lin, Zi Wang, Wei Li
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetic nephropathy (DN) is a major complication of diabetes. The kidney disease develops in nearly 20%∼40 % of type 2 diabetes (T2D) patients. Ginseng is the root of Panax ginseng C. A. Meyer and has been used in prevention and treatment of diseases for more than 2000 years as a traditional oriental medicine. The 20(R)-ginsenoside Rg3, an active saponin isolated from ginseng, can prevent and treat many diseases. The object of this research was to explore the alleviative effects of 20(R)-Rg3 on DN in mice...
October 19, 2020: Journal of Ethnopharmacology
Abdolhamid Esmaeeli, Fatemeh Ebrahimi, Kaveh Tanha, Majid Assadi, Mohammad Seyedabadi
BACKGROUND: Recruitment of β-arrestin to G protein-coupled receptors (GPCRs), initially described to cause receptor desensitization, has recently been shown to take active roles in cell signaling. We investigated the effects of TRV027, an angiotensin AT1 receptor β-arrestin-biased ligand, as well as losartan and valsartan on cisplatin-induced kidney injury. METHOD: Male Sprague-Dawley rats were treated with angiotensin receptor ligands (1 or 10 mg/kg/day) with or without cisplatin, and kidney variables were monitored using animal SPECT, histopathology, and serum parameters...
October 22, 2020: Pharmacological Reports: PR
Gabriel Stefan, Ruxandra Busuioc, Simona Stancu, Madalina Hoinoiu, Adrian Zugravu, Nicoleta Petre, Gabriel Mircescu
INTRODUCTION: Data on pathologic features with prognostic utility in adults with minimal change disease (MCD) are limited. We assessed the relationship between histologic chronic changes and clinical presentation and outcomes. METHODS: The consecutive records of 79 patients with MCD and minimum of 6 months follow-up were retrospectively reviewed. Kidney survival was the primary endpoint (doubling serum creatinine or dialysis initiation). Secondary endpoints were time to remission and relapse...
October 22, 2020: Clinical and Experimental Nephrology
Hiroshi Kusunoki, Shotaro Tsuji, Tomoyuki Kusukawa, Yosuke Wada, Kayoko Tamaki, Koutatsu Nagai, Masako Itoh, Kyoko Sano, Manabu Amano, Hatsuo Maeda, Hideyuki Sugita, Yoko Hasegawa, Hiromitsu Kishimoto, Soji Shimomura, Ken Shinmura
BACKGROUND: Sarcopenia is prevalent in patients with chronic kidney disease (CKD). The indices of physical function, such as grip power and gait speed, decreased according to the decline in the estimated glomerular filtration rate (eGFR). METHODS: We examined the relationships between cystatin C-based GFR (eGFRcys), creatinine-based GFR (eGFRcre), their ratio (eGFRcys/eGFRcre) and sarcopenia in community-dwelling older adults in Japan. This cross-sectional study included 302 men aged 73...
October 22, 2020: Clinical and Experimental Nephrology
Neda Zafari, Mojtaba Lotfaliany, Graeme J O'Keefe, Kartik Kishore, Niloufar Torkamani, Richard J MacIsaac, Leonid Churilov, Elif I Ekinci
AIMS: To evaluate diagnostic performance of glomerular filtration rate (GFR) estimated by modification of diet in renal disease (MDRD), chronic kidney disease epidemiology collaboration (CKD-EPI), full age spectrum (FAS), and revised Lund-Malmo (r-LM) equations in adults with diabetes. METHODS: Individuals were included in this cross-sectional study if they had at least one measurement of technetium-99m diethylenetriamine-pentaacetic acid ( 99mTc-DTPA) GFR (mGFR) and serum creatinine (1487 patients with 2703 measures)...
October 22, 2020: Journal of Clinical Endocrinology and Metabolism
Hong-Ying Guo, Zheng-Guo Zhang, Yu-Yi Zhang, Xue Mei, Yu Liu, Jie-Fei Wang, Zhi-Ping Qian, Wei Yuan
BACKGROUND/AIMS: This study aimed to provide supporting evidence for prevention and prognostic evaluation of bleeding complications in the early stage by exploring the risk and predicting factors in patients with acute-on-chronic liver failure (ACLF). MATERIALS AND METHODS: A total of 101 hospitalized patients with ACLF were retrospectively included from January 1, 2014 to December 31, 2015. The patients were divided into bleeding (n=38) and nonbleeding groups (n=63)...
September 2020: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Venketesh N Dubey, Jugal M Dave, John Beavis, David V Coppini
BACKGROUND: A risk assessment tool has been developed for automated estimation of level of neuropathy based on the clinical characteristics of patients. The smart tool is based on risk factors for diabetic neuropathy, which utilizes vibration perception threshold (VPT) and a set of clinical variables as potential predictors. METHODS: Significant risk factors included age, height, weight, urine albumin-to-creatinine ratio, glycated hemoglobin, total cholesterol, and duration of diabetes...
October 22, 2020: Journal of Diabetes Science and Technology
Shuiming Guo, Fuxiang Zhang, Ying Chen, Yuetao Chen, Nelli Shushakova, Ying Yao, Rui Zeng, Junhua Li, Xia Lu, Rongjun Chen, Hermann Haller, Faikah Gueler, Gang Xu, Song Rong
Postischemic acute kidney injury (AKI) is a common clinical complication and often fatal, with no effective treatment available. Little is known about the role of leukocytes trapped in renal vessels during ischemia-reperfusion injury (IRI) in the postischemic AKI. We designed a new animal model in rats with preforming renal artery lavage prior to IRI to investigate the effect of diminishing the residual circulating leukocytes on kidney damage and inflammation. Moreover, the functional changes of macrophages in hypoxia reoxygenation condition were also analyzed...
October 21, 2020: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Chris H L Thio, Sander K R van Zon, Peter J van der Most, Harold Snieder, Ute Bültmann, Ron T Gansevoort
Both genetic predisposition and low educational attainment (EA) are associated with higher risk of chronic kidney disease. We examined the interaction of EA and genetic risk in kidney function outcomes. We included 3,597 participants from the Prevention of REnal and Vascular ENd stage Disease Cohort Study, a longitudinal study in a community-based sample from Groningen, the Netherlands (median follow-up 11 years, 1997-2012). Kidney function was approximated by estimating glomerular filtration rate (eGFR) from serum creatinine and cystatin C...
October 22, 2020: American Journal of Epidemiology
Laura Bergantini, Miriana d'Alessandro, Lucia Vietri, Giuseppe Domenico Rana, Paolo Cameli, Silvia Acerra, Piersante Sestini, Elena Bargagli
Interstitial lung diseases (ILD) are a heterogeneous group of illnesses of known and unknown aetiology. Differential diagnosis among the three disorders is often challenging. Specific biomarkers with good sensitivity and specificity are therefore needed to predict clinical outcome and guide clinical decisions. The aim of this study was to investigate inflammatory/fibrotic biomarkers, to determine whether single mediators or panels of mediators could be useful to stratify patients into three distinct domains: sarcoidosis, idiopathic pulmonary fibrosis (IPF) and chronic hypersensitivity pneumonitis (cHP)...
October 22, 2020: Immunologic Research
Rouvick M Gama, Katherine Clark, Mahua Bhaduri, Amanda Clery, Kelly Wright, Priscilla Smith, Hayley Martin, Royce P Vincent, Satish Jayawardene, Kate Bramham
BACKGROUND: Acute kidney injury (AKI) in pregnancy (Pr-AKI) is associated with substantial maternal morbidity and mortality. E-alerts are routinely used for detection of AKI in non-pregnant patients but their role in maternity care has not been explored. METHODS: All pregnant or postpartum women with AKI e-alerts for AKI Stages 1-3 (Kidney Disease Improving Global Outcomes (KDIGO) criteria) were identified at a tertiary centre >2 years. Two women matched by delivery date for each case were selected as controls...
October 22, 2020: Nephrology, Dialysis, Transplantation
Wahyu Priatno, Yong-Ho Jo, Jalil Ghassemi Nejad, Jae-Sung Lee, Jun-Ok Moon, Hong-Gu Lee
This study investigated the effects of dietary rumen-protected L-tryptophan (TRP) supplementation (43.4 mg of L-tryptophan kg-1 body weigt [BW]) for 65 days in Hanwoo steers on muscle development related to gene expressions and adipose tissue catabolism and fatty acid transportation in longissimus dorsi muscles. Eight Hanwoo steers (initial BW = 424.6 kg [SD 42.3]; 477 days old [SD 4.8]) were randomly allocated to two groups (n = 4) of control and treatment and were supplied with total mixed ration (TMR). The treatment group was fed with 15 g of rumen-protected TRP (0...
September 2020: Journal of Animal Science and Technology
Yang Mei, Samuel E Weinberg, Lihui Zhao, Adam Frink, Chao Qi, Amir Behdad, Peng Ji
Background: The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 overlaps with the flu season. Methods: We compared clinical and laboratory results from 719 influenza and 973 COVID-19 patients from January to April 2020. We compiled laboratory results from the first 14 days of the hospitalized patients using parameters that are most significantly different between COVID-19 and influenza and hierarchically clustered COVID-19 patients. Findings: Compared to influenza, patients with COVID-19 exhibited a continued increase in white blood cell count, rapid decline of hemoglobin, more rapid increase in blood urea nitrogen (BUN) and D-dimer, and higher level of alanine transaminase, C-reactive protein, ferritin, and fibrinogen...
September 2020: EClinicalMedicine
Michael R Goetsch, Ashutosh Tamhane, Edgar T Overton, Graham C Towns, Ricardo A Franco
Background: Direct-acting antiviral (DAA) therapy among hepatitis C virus (HCV)-infected kidney transplant recipients is associated with short-term improvement in protein/creatinine (P/C) ratios, but how HCV cure affects long-term graft outcomes remains unknown. Methods: This is a retrospective follow-up study of 59 HCV-infected patients who underwent kidney transplant at the University of Alabama at Birmingham between 2007-2015 who were followed until the end of 2017...
2020: Pathogens & Immunity
Seda Dagar, Emine Emektar, Hüseyin Uzunosmanoglu, Yunsur Cevik
OBJECTIVES: The aim of the present study was to perform a demographic analysis of complications and to determine the factors affecting in-hospital mortality in geriatric patients with warfarin overdose. MATERIALS AND METHODS: All patients aged 65 years or older using warfarin with an international normalized ratio (INR) level above 3.5 IU between 01.01.2014 and 01.01.2018 were included in the study. Characteristics of patients with in-hospital mortality and surviving patients were compared...
October 2020: Turkish Journal of Emergency Medicine
Sunil K Kota, Siva K Kota, Sruti Jammula, P R K Bhargav, Abhay K Sahoo, Sambit Das, Satish C Talluri, Srikanth Kongara, S V S Krishna, K D Modi
Background: Persistent elevation of serum parathyroid hormone (PTH) despite normocalcemia have been documented in 8- 40% of patients after parathyroidectomy. We hereby report our experience from different centers across India to determine clinical significance of postoperatively elevated PTH levels and review relevant literature. Methods: We conducted a retrospective case series study and reviewed all the patients who underwent surgery for primary hyperparathyroidism (PHPT) from April 2010 to January 2020...
July 2020: Indian Journal of Endocrinology and Metabolism
Chahat Jhatta, Jashan Girdhar, Sumeet Gupta, Inderjeet Verma
Background: Cystatin C is a non-glycosylated basic protein that is produced and secreted at a constant rate by all nucleated cells. Cystatin C is a more reliable marker than the serum creatinine because it is less affected by external factors such as gender, race and muscle mass. However, the comparison of serum cystatin C level in type 2 diabetes mellitus is not well known in people with obesity. Objectives: To estimate the level of cystatin C in type 2 diabetes and that can be explained by the change in obesity...
July 2020: Indian Journal of Endocrinology and Metabolism
Avinoam Markovich, Ohad Ronen
Acute suppurative parotitis (ASP) is an acute infection of the parotid gland that necessitates hospitalization in some patients. The aim of this study was to evaluate clinical laboratory values including hydration, nutritional status, inflammatory markers and age, and to compare them with duration of hospitalization of patients with ASP. This is a retrospective chart review in a tertiary academic center. We investigated the factors affecting length of hospitalization in patients admitted to Galilee Medical Center with a diagnosis of ASP between 2010 and 2018...
October 21, 2020: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Yanyun Tao, Yuzhen Zhang, Bin Jiang
BACKGROUND: Vitamin K antagonist (warfarin) is the most classical and widely used oral anticoagulant with assuring anticoagulant effect, wide clinical indications and low price. Warfarin dosage requirements of different patients vary largely. For warfarin daily dosage prediction, the data imbalance in dataset leads to inaccurate prediction on the patients of rare genotype, who usually have large stable dosage requirement. To balance the dataset of patients treated with warfarin and improve the predictive accuracy, an appropriate partition of majority and minority groups, together with an oversampling method, is required...
October 22, 2020: BMC Medical Genomics
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