Nicola Melillo, Daniel Scotcher, J Gerry Kenna, Claudia Green, Catherine D G Hines, Iina Laitinen, Paul D Hockings, Kayode Ogungbenro, Ebony R Gunwhy, Steven Sourbron, John C Waterton, Gunnar Schuetz, Aleksandra Galetin
Gadoxetate, a magnetic resonance imaging (MRI) contrast agent, is a substrate of organic-anion-transporting polypeptide 1B1 and multidrug resistance-associated protein 2. Six drugs, with varying degrees of transporter inhibition, were used to assess gadoxetate dynamic contrast enhanced MRI biomarkers for transporter inhibition in rats. Prospective prediction of changes in gadoxetate systemic and liver AUC (AUCR), resulting from transporter modulation, were performed by physiologically-based pharmacokinetic (PBPK) modelling...
March 10, 2023: Pharmaceutics