Tobias Schmidt, Elisabet Berthold, Sabine Arve-Butler, Birgitta Gullstrand, Anki Mossberg, Fredrik Kahn, Anders A Bengtsson, Bengt Månsson, Robin Kahn
BACKGROUND: Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocytes and macrophages play an important role in adult arthritides, but their role in oligoarticular JIA is less studied. Polarization highly influences monocytes' and macrophages' effector functions, broadly separated into pro-inflammatory M1 or anti-inflammatory M2 phenotypes...
August 12, 2020: Arthritis Research & Therapy
Farhad Salehzadeh, Mehrdad Mirzarahimi
BACKGROUND: Recurrent and relapsing arthritis has been proposed to describe a group of arthritis with recurring and periodic nature, in which the joints are intermittently involved. This study reports three non-FMF patients with heterozygous MEFV gene mutations and an extraordinary arthritis as a recurrent synovitis of hip (RSH). METHODS: During 16-years from 2003 to 2019 at pediatric rheumatologic clinic among 195 recorded files with chronic oligoarthritis, 3 patients with diagnosis of recurrent synovitis of hip (RSH) were reviewed thoroughly...
August 10, 2020: Pediatric Rheumatology Online Journal
L von Schuckmann, J Klotsche, A Suling, B Kahl-Nieke, I Foeldvari
OBJECTIVE: To study the proportion of patients with temporomandibular joint (TMJ) involvement among patients with juvenile idiopathic arthritis (JIA), as well as associated clinical characteristics and signs/symptoms. METHOD: We performed a retrospective chart review on consecutive patients followed in the Hamburg Centre for Paediatric and Adolescent Rheumatology Eilbek between January 2010 and July 2012. TMJ involvement was diagnosed based on clinical examination; a subgroup of patients was also assessed by magnetic resonance imaging (MRI)...
July 2020: Scandinavian Journal of Rheumatology
Hannah den Braanker, Kim Wervers, Adriana M C Mus, Priyanka S Bangoer, Nadine Davelaar, Jolanda Luime, Ilja Tchetverikov, J M W Hazes, Marijn Vis, Erik Lubberts, Marc R Kok
OBJECTIVES: Methotrexate (MTX) is currently the recommended first-line therapy for treating psoriatic arthritis (PsA), despite lacking clear evidence. No estimates of efficacy of MTX in usual care and no clear MTX responsive clinical or laboratory variables are currently available. This study describes the response to MTX monotherapy in newly diagnosed patients with PsA in usual care. Second, we compared clinical variables and cytokine profiles in patients responding and not responding to MTX monotherapy...
July 2020: RMD Open
B V Zavodovsky, L E Sivordova, Y V Polyakova, Y R Akhverdyan, E V Papichev
AIM: To evaluate the effectiveness and tolerability of the drug in patients with undifferentiated peripheral inflammatory arthritis (UPIA). MATERIALS AND METHODS: We observed 60 patients (39 women and 21 men) met G. Hazlewood et al., UPIA criteria, 2011. Patients were divided into 3 groups: with monoarthritis, oligoarthritis and polyarthritis. They took aceclofenac 100 mg twice day for 3 weeks. RESULTS: We noted significant decreasing in pain level according to visual analogue scale: in patients with monoarthritis by 69...
June 5, 2020: Terapevticheskiĭ Arkhiv
Gizem Ayan, Dilek Solmaz, Sibel Bakirci, Ilaria Tinazzi, Ahmet Omma, Orhan Kucuksahin, Cem Ozisler, Sule Yavuz, Ozun Bayindir, Gezmis Kimyon, Atalay Dogru, Emine Figen Tarhan, Meryem Can, Levent Kilic, Mehmet Tuncay Duruoz, Kenan Aksu, Umut Kalyoncu, Sibel Zehra Aydin
OBJECTIVE: Joints with different sizes and anatomical locations can be affected in psoriatic arthritis (PsA). Our aim was to explore the effect of different joint patterns on patient-reported outcomes (PROs) in patients with mono-oligoarthritis. METHODS: Within PsArt-ID (Psoriatic Arthritis- International Database), 387/1670 patients who had mono-oligoarthritis (1-4 tender and swollen joints) were enrolled in cross-sectional assessment. The joints were categorized according to their size (small/large) and location (upper/lower extremity) and PROs, physician global assessment and C-reactive protein (CRP) were compared...
June 22, 2020: International Journal of Rheumatic Diseases
Mihaela Gamala, Johannes W G Jacobs, Suzanne P Linn-Rasker, Maarten Nix, Ben G F Heggelman, Pieternel C M Pasker-de Jong, Jacob M van Laar, Ruth Klaasen
OBJECTIVES: Chronic inflammation associated with hyperuricaemia and urate deposition may contribute to an increased risk of developing cardiovascular (CV) events (CVE) in patients with gout. The aim of this study was to explore whether urate deposition on dual-energy CT (DECT) present at the diagnosis of gout is associated with a history of CVE. METHODS: Patients from a study on clinical value of DECT with mono or oligoarthritis who had gout according the 2015 EULAR/ACR classification criteria were included in this cross-sectional study...
July 2020: Clinical and Experimental Rheumatology
Laure Gossec, Xenofon Baraliakos, Andreas Kerschbaumer, Maarten de Wit, Iain McInnes, Maxime Dougados, Jette Primdahl, Dennis G McGonagle, Daniel Aletaha, Andra Balanescu, Peter V Balint, Heidi Bertheussen, Wolf-Henning Boehncke, Gerd R Burmester, Juan D Canete, Nemanja S Damjanov, Tue Wenzel Kragstrup, Tore K Kvien, Robert B M Landewé, Rik Jozef Urbain Lories, Helena Marzo-Ortega, Denis Poddubnyy, Santiago Andres Rodrigues Manica, Georg Schett, Douglas J Veale, Filip E Van den Bosch, Désirée van der Heijde, Josef S Smolen
OBJECTIVE: To update the European League Against Rheumatism (EULAR) recommendations for the pharmacological treatment of psoriatic arthritis (PsA). METHODS: According to the EULAR standardised operating procedures, a systematic literature review was followed by a consensus meeting to develop this update involving 28 international taskforce members in May 2019. Levels of evidence and strengths of recommendations were determined. RESULTS: The updated recommendations comprise 6 overarching principles and 12 recommendations...
June 2020: Annals of the Rheumatic Diseases
Manasita Tanya, Kai Liang Teh, Lena Das, Sook Fun Hoh, Xiaocong Gao, Thaschawee Arkachaisri
OBJECTIVES: To examine the clinical characteristics, treatment and outcomes of juvenile idiopathic arthritis (JIA) patients evaluated in Singapore and compare those with reports elsewhere. METHODS: Patients with JIA were recruited from our Singapore pediatric rheumatology registry from January 1997 to December 2015. Demographic, clinical, treatment, and outcome data were retrospectively collected. Nonparametric statistics were used to describe the data. Chi-squared, Mann-Whitney U, or Kruskal-Wallis tests were applied to compare differences between groups where appropriate...
May 16, 2020: Clinical Rheumatology
Amieleena Chhabra, Cal Robinson, Kristin Houghton, David A Cabral, Kimberly Morishita, Lori B Tucker, Ross E Petty, Maggie Larché, Michelle Batthish, Jaime Guzman
OBJECTIVE: To assess long-term outcomes of children with JIA diagnosed in the biologic era. METHODS: Chart review of patients prospectively enrolled in the Research in Arthritis in Canadian Children Emphasizing Outcomes inception cohort at two Canadian centres. Inactive disease and remission were defined according to Wallace criteria. RESULTS: We included 247 of 254 (97%) eligible patients diagnosed 2005-10. At the last follow-up visit at a median age of 16...
May 13, 2020: Rheumatology
Nilasha Ghosh, Michael D Tiongson, Carolyn Stewart, Karmela K Chan, Bridget Jivanelli, Laura Cappelli, Anne R Bass
OBJECTIVE: We performed a systematic literature review to identify all reports of immune checkpoint inhibitor-associated inflammatory arthritis to describe it phenotypically and serologically. METHODS: PubMed, Embase, and Cochrane databases were searched for reports of musculoskeletal immune-related adverse events secondary to ICI treatment. Publications were included if they provided individual patient level data regarding the pattern of joint involvement. Descriptive statistics were used to summarize results...
April 25, 2020: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Juliana de Oliveira Alves Calado, Anna Carolina Miola, Maria Regina Cavariani Silvares, Silvio Alencar Marques
Cutaneous tuberculosis is a rare extrapulmonary manifestation of tuberculosis which, like disseminated tuberculosis, commonly occurs in immunocompromised patients. Poncet reactive arthritis is a seronegative arthritis affecting patients with extrapulmonary tuberculosis, which is uncommon even in endemic countries. We report a previously healthy 23-year-old male patient with watery diarrhea associated with erythematous ulcers on the lower limbs and oligoarthritis of the hands. Histopathological examination of the skin showed epithelioid granulomatous process with palisade granulomas and central caseous necrosis...
March 20, 2020: Anais Brasileiros de Dermatologia
Lianne Kearsley-Fleet, Eleanor Heaf, Rebecca Davies, Eileen Baildam, Michael W Beresford, Helen E Foster, Taunton R Southwood, Wendy Thomson, Kimme L Hyrich
Background: Information is scarce about biological disease-modifying antirheumatic drug (DMARD) switching patterns in children and young people (aged ≤16 years) with juvenile idiopathic arthritis in an era of many biologic therapies. The best choice of biologic to use if the first biological DMARD is not beneficial also remains unclear. We aimed to quantify and characterise biologic switching patterns in children and young people with juvenile idiopathic arthritis, and to compare the effectiveness of using a second tumour necrosis factor inhibitor (TNFi) versus non-TNF is following failure of a first TNFi biologic in routine clinical practice...
April 2020: The Lancet Rheumatology
Durga Prasanna Misra, Neeraj Jain, Gangadharan Harikrishnan, Vikas Agarwal
A 57-year old gentleman had presented a year back with inflammatory oligoarthritis and vasculitic neuropathy, diagnosed as unclassifiable vasculitis, initiated on oral corticosteroids and intravenous cyclophosphamide (monthly X 6). His disease stabilized and he had been maintained on azathioprine, which had to be stopped due to acute pancreatitis with subsequent pseudocyst formation, requiring percutaneous drainage suspecting infection. Within a week of pseudocyst drainage, he developed sudden onset pain in left upper limb, with absent left upper limb pulses, loss of motor function of left hand, myocardial ischemia, and extensive thrombosis of the left upper limb arteries...
May 2020: International Journal of Rheumatic Diseases
Karoline Walscheid, Jens Klotsche, Christoph Tappeiner, Martina Niewerth, Dirk Foell, Kirsten Minden, Arnd Heiligenhaus
OBJECTIVES: As JIA-associated uveitis (JIAU) is asymptomatic in the majority of patients, ophthalmologic screening examinations are recommended, depending on the risk constellation for uveitis development. This study analyses disease characteristics in JIAU depending on adherence with the screening intervals. METHODS: 953 patients were included in the ICON registry. In patients without uveitis, ophthalmologic screening was recommended in accordance with the standards currently applied in Germany...
July 2020: Clinical and Experimental Rheumatology
Elena Bertolini, Pierluigi Macchioni, Fernando Rizzello, Marco Salice, Gentiana Vukatana, Gilda Sandri, Angela Bertani, Giovanni Ciancio, Marcello Govoni, Angelo Zelante, Nazzarena Malavolta, Marina Beltrami, Carlo Salvarani
AIMS: To evaluate the prevalence of clinical and ultrasonographic musculoskeletal involvement in Italian patients with inflammatory bowel disease (IBD). METHODS: In this cross-sectional multicenter study, 148 consecutive patients with IBD were evaluated by a gastroenterologist and a rheumatologist. All patients underwent a B-mode and power Doppler ultrasonographic examination of 6 pairs of entheses and of knee and ankle joints. RESULTS: A positive history for at least one musculoskeletal manifestation was reported by 40...
June 2020: Seminars in Arthritis and Rheumatism
Ann Andee Wang, Elyse Anna Linson
Neisseria gonorrhoeae is the causative organism in 0.6%-1.2% of septic arthritis cases in North America and Europe, and classically presents as migratory polyarthralgias and tenosynovitis, with later development of septic oligoarthritis. In men, urine gonorrhoea nucleic amplification testing (NAAT) is the preferred diagnostic test, as its sensitivity surpasses that of joint and blood culture in disseminated infections. We present a case of a previously healthy man who presented with septic arthritis of the wrist...
February 3, 2020: BMJ Case Reports
X Baraliakos, A Kleyer, D Simon, M Köhm, S Ohrndorf, P Sewerin
Psoriatic arthritis (PsA) is a heterogeneous multifactorial disease with musculoskeletal involvement, which can be manifested as monoarthritis, oligoarthritis or polyarthritis and in some patients can also affect the axial skeleton. The most frequent indications of inflammation are bone marrow edema and enthesitis. The early and differential diagnosis of PsA is a clinical challenge, particularly as a differential diagnosis from other inflammatory or degenerative diseases of joints. Inflammatory joint and tendon alterations in the region of the extremities and the spine can be visualized with high sensitivity by the use of magnetic resonance imaging (MRI), musculoskeletal sonography (US) and fluorescence optical imaging (FOI)...
February 2020: Zeitschrift Für Rheumatologie
Mihaela Gamala, Johannes W G Jacobs, Suzanne P Linn-Rasker, Maarten Nix, Ben G F Heggelman, Pieternel C M Pasker-de Jong, Jacob M van Laar, Ruth Klaasen
OBJECTIVES: Chronic inflammation, as seen in gout, may contribute to an increased risk of developing cardiovascular (CV) events (CVE). The aim of the study was to explore the effect of adding gout as a chronic inflammatory disease to the Dutch SCORE, a tool predicting 10-year CV mortality and morbidity. METHODS: This was a cross-sectional substudy including new patients with gout according the 2015 EULAR/ACR classification criteria who had participated in a trial on diagnostic accuracy of DECT with mono or oligoarthritis...
November 20, 2019: Clinical and Experimental Rheumatology
Estefanía Barral Mena, Luis Miguel García Cárdaba, Anna Canet Tarrés, Eugenia Enríquez Merayo, Alejandro Cruz Utrilla, Jaime de Inocencio Arocena
INTRODUCTION: Methotrexate (MTX) is the drug of choice for juvenile idiopathic arthritis. Its clinical efficacy is limited due to the development of adverse effects (AEs). PATIENTS AND METHODS: A retrospective observational study was conducted on the AEs associated with MTX therapy in children diagnosed with juvenile idiopathic arthritis followed-up in a tertiary hospital between 2008 and 2016. RESULTS: The study included a total of 107 patients, of whom 71 (66...
November 4, 2019: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
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